Gene Information

Name : guaA (SPC_1145)
Accession : YP_002636752.1
Strain : Salmonella enterica RKS4594
Genome accession: NC_012125
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 1209723 - 1211300 bp
Length : 1578 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACGGAAAACATTCATAAGCATCGCATCCTCATTCTGGACTTCGGTTCTCAGTACACTCAACTGGTTGCGCGCCGCGT
GCGTGAGCTGGGTGTTTACTGCGAACTGTGGGCGTGGGATGTGACAGAAGCACAAATTCGTGACTTCAACCCAAGCGGCA
TTATTCTTTCCGGCGGCCCGGAAAGCACCACCGAAGAAAACAGCCCGCGCGCGCCGCAGTATGTCTTTGAAGCAGGCGTG
CCGGTATTTGGCGTTTGCTATGGGATGCAGACCATGGCGATGCAGCTTGGCGGTCATGTAGAAGGTTCTAATGAGCGTGA
ATTTGGTTATGCGCAGGTTGAAGTGTTGACCGACAGCGCGCTGGTTCGCGGTATTGAAGATTCCCTGACCGCAGACGGCA
AACCGCTGCTGGACGTGTGGATGAGCCACGGCGATAAAGTGACGGCGATTCCGTCCGACTTCGTGACCGTCGCCAGCACC
GAGAGCTGCCCGTTCGCCATTATGGCCAACGAAGAAAAACGCTTCTACGGTGTACAGTTCCACCCGGAAGTGACCCACAC
CCGCCAGGGTATGCGCATGCTGGAGCGTTTTGTGCGTGATATCTGCCAGTGTGAAGCGCTGTGGACGCCGGCGAAGATCA
TCGACGACGCCGTGGCGCGCATTCGCGAGCAGGTAGGCGACGATAAAGTGATCCTCGGTCTCTCCGGCGGCGTGGATTCT
TCCGTCACCGCGATGCTGCTGCACCGCGCGATCGGTAAAAATCTGACCTGTGTATTCGTCGACAACGGCCTGCTGCGTCT
CAACGAAGCCGAGCAGGTGATGGACATGTTTGGCGACCATTTTGGCCTGAATATCGTTCACGTTCCGGCGGAAGAGCGCT
TCCTGTCCGCGTTGGCTGGCGAAAACGATCCAGAAGCCAAGCGTAAGATCATTGGCCGTGTTTTTGTGGAAGTGTTCGAC
GAAGAAGCGCTGAAACTGGAAGACGTGAAATGGCTGGCGCAGGGCACCATCTACCCTGACGTTATCGAATCTGCGGCGTC
TGCAACCGGTAAAGCGCACGTCATCAAATCTCACCACAATGTCGGCGGCCTGCCGAAAGAGATGAAGATGGGTCTGGTTG
AACCGCTGAAAGAGCTGTTCAAAGACGAAGTGCGTAAGATTGGTCTGGAGCTGGGCCTGCCGTACGACATGCTGTATCGC
CATCCGTTCCCGGGGCCGGGCCTCGGCGTGCGCGTACTGGGCGAAGTGAAGAAAGAGTACTGCGACCTGCTGCGTCGCGC
GGACGCTATCTTCATTGAAGAGCTGCGCAAAGCGGATCTGTACGACAAAGTCAGTCAGGCGTTTACCGTCTTCCTGCCGG
TCCGTTCCGTTGGCGTCATGGGCGATGGTCGTAAGTATGACTGGGTTGTCTCTCTGCGTGCCGTCGAAACCATCGACTTT
ATGACCGCACACTGGGCGCACCTGCCGTATGACTTCCTCGGTCGTGTTTCCAACCGCATCATCAATGAAGTCAACGGGAT
TTCCCGTGTGGTGTATGACATCAGCGGTAAACCACCGGCTACCATTGAGTGGGAATGA

Protein sequence :
MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGV
PVFGVCYGMQTMAMQLGGHVEGSNEREFGYAQVEVLTDSALVRGIEDSLTADGKPLLDVWMSHGDKVTAIPSDFVTVAST
ESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDS
SVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVMDMFGDHFGLNIVHVPAEERFLSALAGENDPEAKRKIIGRVFVEVFD
EEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-127 51
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 9e-128 51
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 7e-128 51
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-110 48