Gene Information

Name : pykA (Sca_1303)
Accession : YP_002634393.1
Strain : Staphylococcus carnosus TM300
Genome accession: NC_012121
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 1313884 - 1315644 bp
Length : 1761 bp
Strand : -
Note : similar to Pyruvate kinase pyk, (EC 2.7.1.40),Bacillus stearothermophilus, 587AA, Expect = 0.0,Identities = 357/585 (61%), Positives = 448/585 (76%),(P51182) Pyruvate kinase (EC 2.7.1.40) (PK),InterPro: Pyruvate kinase; Hypothetical protein

DNA sequence :
ATGAGAAAAACTAAAATCGTTTGTACGATTGGACCTGCATCAGAATCTGAAGAAATGTTAGAAAAATTAATGAAAGCTGG
AATGAACGTTGCGCGTTTGAACTTCTCACACGGTGATCATGCAGAACATAAAGCGCGTATCGAGCGTATTCGTGAAGTAT
CTCAACGTTTAAACAAAACTATCGCTATTATGCTTGATACAAAAGGACCAGAAATTCGTACTCATGATATGGAAAACGGC
GTTATTAATTTAGAAAAAGGTAATGATGTTATTGTCAGCATGAATCAAGTTTTAGGTACTGCTGATAAATTTTCAGTGAC
TTACGAAGACCTTATTAATGACGTTGAAATCGGTTCTTTCATCTTACTTGATGACGGTCTTGTAGAATTAGAAGTTAAAG
CTAAAGATAAAGAAAAAGGCGAAGTATTATGTGAAGTCTTAAACTCTGGTGAAATTAAAAATAAAAAAGGTGTTAACTTG
CCAAATGTAAAAGTTAATTTACCAGGTATCACAGAAAAAGATGCAGATGATATCCGCTTTGGTATTGATGAGCATGTTGA
TTTTATCGCTGCTAGTTTTGTTCGTCGTCCAAGTGATGTTTTGGATATTCGTAAAATTTTAGAAGAAGAACGCAATACAA
ATATCAGCATTCTTCCTAAAATCGAAAACCAAGAAGGTATCGACAATATTAAAGAAATTCTAGAAGTTTCTGATGGCTTA
ATGGTAGCTCGTGGTGATATGGGTGTTGAAATTCCACCTGAGAATGTACCAGTTATCCAAAAAGATTTAATCAGACAATG
TAACAAATTAGGTAAACCAGTTATCACAGCTACTCAAATGTTAGATTCTATGCAACGTAACCCGCGTGCTACAAGAGCAG
AAGCAAGTGATGTAGCCAATGCTATCTATGATGGTACAGATGCAGTTATGTTATCTGGTGAAACTGCTGCTGGTTTATAT
CCTGAAGAAGCGGTTAAAGCAATGAGAAACATTGCAGTTGCTGCTGAAGCTGCACAAGATTATAAAAAATTATTGAATGA
CAGAACTAAACTGGAAGAAACAAACTTAGTAAATGCTATTGGTGTTTCTGTAGCTCATACAGCTTTAAACTTGAAAGTTA
AAGCAATCGTAGCGGCTACTGAAAGTGGATCAACAGCTAAAACAATTTCTAAATTCCGTCCTCATTCAGACATTATTGCT
GTAACTCCAAGTCCAGAAACTGCGCGCCAATTGGCATTAGTATGGGGTGTGTTCCCAGTAGTTAAAAAAGGACGTAAAAC
TACAGATGCTTTATTAAACAATGCTGTTGCTACTGCAATTGAAACTGGTCGTGTACAAAATGGTGACTTATTAATTATCA
CTGCTGGTGTACCAACTGGTGAAAAAGGTACAACTAACATGATGAAATTACATTTAGTTGGTGACGAAATTGTTAAAGGT
CAAGGTGTCGGCCGTAATTCAGTAGTAGGAAATGCAATTGTTGTTCAAGATGCAATTGAGTTAGAAGGAAGAGATCTTTC
AAACAAAATTATTGTAACGCATTCAACTGATGAAACATTCGTTCCATATATTGAACAAGCAGCTGGTTTAGTAGCTGAAG
AAGGCGGTATTACTTCTCCAAGCGCAATCATCGGCTTAGAACAAGGTATCCCAACAATTGTTGGCGCTAGCAATGCAACT
AAATTAATCGCAAATGACGTTGTGATTACTGTTGATGCCAACACTGGTCGTGTATATGATGGTTATGCAAACGTACTTTA
A

Protein sequence :
MRKTKIVCTIGPASESEEMLEKLMKAGMNVARLNFSHGDHAEHKARIERIREVSQRLNKTIAIMLDTKGPEIRTHDMENG
VINLEKGNDVIVSMNQVLGTADKFSVTYEDLINDVEIGSFILLDDGLVELEVKAKDKEKGEVLCEVLNSGEIKNKKGVNL
PNVKVNLPGITEKDADDIRFGIDEHVDFIAASFVRRPSDVLDIRKILEEERNTNISILPKIENQEGIDNIKEILEVSDGL
MVARGDMGVEIPPENVPVIQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGLY
PEEAVKAMRNIAVAAEAAQDYKKLLNDRTKLEETNLVNAIGVSVAHTALNLKVKAIVAATESGSTAKTISKFRPHSDIIA
VTPSPETARQLALVWGVFPVVKKGRKTTDALLNNAVATAIETGRVQNGDLLIITAGVPTGEKGTTNMMKLHLVGDEIVKG
QGVGRNSVVGNAIVVQDAIELEGRDLSNKIIVTHSTDETFVPYIEQAAGLVAEEGGITSPSAIIGLEQGIPTIVGASNAT
KLIANDVVITVDANTGRVYDGYANVL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 8e-96 49
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 3e-96 49
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 3e-96 49
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 8e-97 49
pykA NP_273151.1 pyruvate kinase Not tested IHT-A Protein 1e-55 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pykA YP_002634393.1 pyruvate kinase VFG0479 Protein 1e-96 49