Gene Information

Name : guaA (NAMH_0983)
Accession : YP_002607383.1
Strain : Nautilia profundicola AmH
Genome accession: NC_012115
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 900866 - 902401 bp
Length : 1536 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCAAGTTGAAATACTAATACTTGATTTTGGTAGTCAATATACACAATTGATAGCAAGAAGACTAAGAGAAGAGGGTAT
ATACAGTGAAATAGTACCTTACTTTGACGGTCTAAAAGCTGCAAAAGAAAAAAAACCTAAAGGTATTATTTTCAGTGGAG
GACCTGCGAGTGTTTATGAAAAAGACGCATACAGAGTTGATAAAGAAATATATGAATTAGGGCTTCCTATCCTTGGTATA
TGTTACGGAATGCAGTTAATTACTGTTGACTTCGGAGGAGAAGTTGTAAGGGCTGACCATCATGAATACGGGAAAGCCGA
GCTTTTTATTGATGAACCGCATAAACTGTTTGATGATGTAAGTAATCCTACAATCGTTTGGATGAGTCACGGTGACAGAG
TTGAGAAATTGGCTCCCGGATTTAAAAGAATTGCTCATACTTCAAACGCACCTTATGCTGCAATCGTAAATGAAGAAAAA
GAGATTTACGCAATTCAGTTCCATCCTGAAGTTACTCACAGCGTTGAAGGTCAGAAAATTTTAAGAAACTTCGCAAGAAA
CGTATGTGGTGTAACAAGCAAATGGGATATGGCGCACTTCGCAAAAGAACAGATTAAAAAAATCAGAGAACAAGTTGGTG
ACAATAAAGTAATATGTGCATTAAGCGGAGGAGTTGACAGCTCTGTTACAGCAGCGCTTTTACATGAAGCTATAGGTGAT
AAACTTGTACCTATTTTTGTGGATACCGGACTTCTTAGAAAAAATGAAAGAGAGCAGGTGGAGCATGCATTTAAAAACGT
ACTTCACGTACCTTTAATTACAGTTGATGCAAGAGAAAAATTCTTAAGTAAACTAAAAGGCGTTGTGGATCCTGAAGAGA
AAAGAAAAATTATCGGGCATACGTTTATCGAAGTGTTTGACGAAGAAGCAAAAAAACACAAAGACGCTAAATTCTTGGCA
CAGGGAACACTGTATCCTGACGTAATTGAAAGCGTAAGCGTAAAAGGCCCTTCTAAAACAATTAAATCGCATCATAATGT
TGGCGGACTTCCTGATTGGATGCAGTTCGAACTTATTGAACCTTTAAGAGAACTTTTCAAAGATGAAGTTAGAAAACTTG
GAATCGAACTTGGTCTTCCAAGTGAGCTTGTATACAGACATCCGTTCCCTGGACCTGGACTTGCTATTAGAATTATGGGT
GAGGTTAATGAAGAAGATCTAAACATATTAAGAGAAGCCGACGCTATTTTAATTCAGGAACTAAAAGCATGGGGACTATA
CAATGATGTATGGCAGGCTTTTGCGGTACTTCTTAACGTAAGAAGTGTTGGTGTTATGGGTGATAACAGAACATATGACA
ATACCGTAGCAATCAGATGCGTAAGCTCGACAGACGGTATGACGGCGACATTCAGTCATTTGCCTCATGAGTTTCTTGAG
AGGGTAAGCACAAGAATTATCAACGAAGTTGACGGAATCAACAGAGTTGTTTATGATATTTCAAGTAAACCGCCTGCAAC
AATCGAGTGGGAATAA

Protein sequence :
MQVEILILDFGSQYTQLIARRLREEGIYSEIVPYFDGLKAAKEKKPKGIIFSGGPASVYEKDAYRVDKEIYELGLPILGI
CYGMQLITVDFGGEVVRADHHEYGKAELFIDEPHKLFDDVSNPTIVWMSHGDRVEKLAPGFKRIAHTSNAPYAAIVNEEK
EIYAIQFHPEVTHSVEGQKILRNFARNVCGVTSKWDMAHFAKEQIKKIREQVGDNKVICALSGGVDSSVTAALLHEAIGD
KLVPIFVDTGLLRKNEREQVEHAFKNVLHVPLITVDAREKFLSKLKGVVDPEEKRKIIGHTFIEVFDEEAKKHKDAKFLA
QGTLYPDVIESVSVKGPSKTIKSHHNVGGLPDWMQFELIEPLRELFKDEVRKLGIELGLPSELVYRHPFPGPGLAIRIMG
EVNEEDLNILREADAILIQELKAWGLYNDVWQAFAVLLNVRSVGVMGDNRTYDNTVAIRCVSSTDGMTATFSHLPHEFLE
RVSTRIINEVDGINRVVYDISSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 6e-146 57
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 5e-146 57
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 5e-146 57
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-126 52