Gene Information

Name : pyk (HRM2_24930)
Accession : YP_002603751.1
Strain : Desulfobacterium autotrophicum HRM2
Genome accession: NC_012108
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 2847194 - 2848609 bp
Length : 1416 bp
Strand : +
Note : pyruvate kinase (PK); catalyzes the formation of phosphoenolpyruvate from pyruvate

DNA sequence :
ATGCGTAGAAAGACAAAAATCGTGGCCACCATATCGGACCGGAACTGTGAGCCGGAATTTTTAAAACAGCTCTACGATGC
AGGAATGGATGTTGTACGCCTGAACACGGCCCACCAGACCCATGAAGATGCCCTGAAGGTGATTGAAAACGTCAGAAAAG
TCTCGAATAAAATCGCCATTCTCATCGACACCAAGGGACCTGAGATCAGAACCTGTGGGGCCGACACCCCCCTCACCGTT
GCCTATGGGGATTTTATCCAAATCAAGGGAGCTCCGGACGAACGTTCTGCAGGCAATATCATCTATGTCTCCTACCCAGG
TTTTGTAAATGACGTTCCCGTGGGAACCACCATCCTCATTGATGACGGATCCATCGCACTTACCGTCAAGGAGAGGAACT
CAGATTTCCTTACCTGTTTTGTGGAAAATGACGGAATCATCTACGGCAGAAAAAGCGTCAACATCCCAGCCGTCCATGTG
AAGCTGCCTGCCTTGAGCGAAAAGGACAAGGGATTCATCCGGTTTGCCGCAGACAACCATGTTGACTTTATTGCCCACTC
CTTTGTCAGGCACAGGGAAGATGTGCTTGCCGTTCAGAGAATCCTGGACGAACGAAAGAGCACCATCAAAATCATTGCAA
AAATCGAAAACAGCGGCGGAGTTGAAAACATCGACGAGATACTCGAAGTGGCCTATGGCATCATGATCGCCAGGGGAGAT
CTTGCCGTTGAGATACCGGCCGAAAAGATCCCTTTGGTTCAAAAAGCCCTGGTGCGGCGCTGTATTGAGAAACGGGCACC
TGTGATTGTAGCCACCCAGATGCTCCATTCCATGATGACATCCCCCAGACCCACACGGGCCGAGGTGTCGGATGTGGCCA
ATGCCTGCCTTGATTCAACCGATGCCCTCATGCTTTCCGGGGAAACGGCCAGTGGCAAGTATCCGTTGTTAGCCGTTCAG
ACCATGGCAAAAATTGCCAACGAGGTCGAGACAAACCGGAGCACCTACATCAACACCCCCTACACCCTTGAAAACAAAAT
AACCGGTTACCTGGCAAAGTCGGCGGTCAAGGCATCCATGCGTCTAAACACCGAGGCCATCGTTGCCGATTCCATAACAG
GTACCACCATCCGGGCCATTGCCGCCTATCGGGGAGACAACCCCATCTATGCCCAGACCTATGATGAAAAGGTAATGCGT
GAACTTGCCCTGAGCTTCGGGGTCCATGCCGATACCATTCAAAGGGAGGAGGCAACCACCATTCCCATTAGAAAGGCAAT
CCTCAGGCTCATCGAACAGGGTATCCTCAAGGAAGACACCCTGATAACGGTTCTTGCCGGTCACTTTGGATCAGATCATG
GCGCCTCTTACATTGAGATAAGCACGGCTAAAAGAATGATGGCAAGGGGATGCTAA

Protein sequence :
MRRKTKIVATISDRNCEPEFLKQLYDAGMDVVRLNTAHQTHEDALKVIENVRKVSNKIAILIDTKGPEIRTCGADTPLTV
AYGDFIQIKGAPDERSAGNIIYVSYPGFVNDVPVGTTILIDDGSIALTVKERNSDFLTCFVENDGIIYGRKSVNIPAVHV
KLPALSEKDKGFIRFAADNHVDFIAHSFVRHREDVLAVQRILDERKSTIKIIAKIENSGGVENIDEILEVAYGIMIARGD
LAVEIPAEKIPLVQKALVRRCIEKRAPVIVATQMLHSMMTSPRPTRAEVSDVANACLDSTDALMLSGETASGKYPLLAVQ
TMAKIANEVETNRSTYINTPYTLENKITGYLAKSAVKASMRLNTEAIVADSITGTTIRAIAAYRGDNPIYAQTYDEKVMR
ELALSFGVHADTIQREEATTIPIRKAILRLIEQGILKEDTLITVLAGHFGSDHGASYIEISTAKRMMARGC

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 3e-68 44
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 2e-68 44
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 2e-68 44
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 2e-67 44

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pyk YP_002603751.1 pyruvate kinase VFG0479 Protein 9e-69 44