Gene Information

Name : guaA (Cla_0501)
Accession : YP_002575100.1
Strain : Campylobacter lari RM2100
Genome accession: NC_012039
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 476724 - 478259 bp
Length : 1536 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAAAAAAGCAGATATTTTGGTTTTGGACTTTGGTTCACAATACACACAACTCATTGCCAGAAGATTAAGGGAGCAAGG
TGTGTATGCAGAAATTTTACCTTTTAATGTAAGTTTAGATGAGATTAAAGCTAAAGAGCCTAAGGGTATTATTTTAAGTG
GTGGGCCAGCTAGTGTATATGCAAATGATGCTTATTTTTGTGATAAGGGTGTTTTTGATTTAAATATACCAGTTTTAGGA
ATTTGTTATGGTATGCAATTAATGGCGCATCATTTTGGGGCAAATGTTGCTCCAGCAGGCCATAAAGAATATGGTAAAGC
AACTATAGATATTCAAAACGATAGTGATTTGTTTAAAAATTTACCTAAAAAGCAAACAGTATGGATGAGCCATTCTGATA
AGGTTGAGAATTTACCACAAGGTTTTGAGGTTTTAGCGACTAGTGAAAATAGTCCATTTTGTGTATTTGGAGATGAGAAG
CGTAAATTTTTTGCTTTACAATTTCACCCCGAAGTTCAACATAGCGAATTTGGAAAAAGCATCTTGAAAAATTTTGCTAA
GTATGCATGTAATTGTGATAGTGTATGGAATATGGGATCTTTTGCAAAAACTCAAGCGCAAAAAATCAAAGAAGAAGTAG
GAAATGATAAAGTTTTATGTGCAGTAAGTGGCGGGGTTGATAGTAGTGTGGTGGCTGCACTGCTTGCTAGTGCGATAAAA
GATCAAGTTGTGGTTGTGTTTGTTGATAATGGGCTTTTAAGAAGTGGCGAAAAAGAGCAAGTTGAGTATATGTTTAAACA
CACTTTGGGTATTGATTTAATTAGCATTGATGCAAGAGAGATTTTCTTAAGTCGTTTAGCAGGAGTGAGAGATCCTGAGC
AAAAAAGAAAAATCATAGGAAATACTTTCATAGAGGTTTTTGAAGAAGAAGCTAAAAAACATAAAGATGTAAAATATTTA
GCACAAGGAACTTTATATACTGATATTATTGAAAGTTCTGTTGTTGGGGCTAGCAAGACTATAAAATCTCACCATAATGT
TGGCGGTTTGCCTGAAAAAATGAATTTAAAACTCATTGAGCCTTTAAAAGAAATTTTTAAAGATGAGGTAAGAGCTTTAG
GAATGGAGCTTGGTTTAAGTAAAGATGTAGTTTATCGCCACCCTTTCCCAGGGCCAGGCCTTGCTATACGTATAATGGGT
GAGGTAAATGAGCCTAGTTTAGAACTTTTAAGAAAAGCTGATGTGATTTTGATAGAAGAGCTGAAAAGTAGTGGTTGGTA
TGATAAAACTTGGCAGGCTTTTTGTGTGCTTTTAAATGTACAAAGTGTTGGTGTAATGGGGGATAATAGAACTTATGATA
ATGCAGTTTGTGTGCGTGTTGTTAATGCAAGCGATGGAATGACTGCAACTTTTTCTCATTTACCATATGAATTATTAGAA
AATATTTCGCGCCGTATTATCAATGAAGTAAATGGGATTAACCGCGTGGTGTATGATATTTCTAGTAAGCCACCAGCAAC
TATTGAGTGGGAATGA

Protein sequence :
MKKADILVLDFGSQYTQLIARRLREQGVYAEILPFNVSLDEIKAKEPKGIILSGGPASVYANDAYFCDKGVFDLNIPVLG
ICYGMQLMAHHFGANVAPAGHKEYGKATIDIQNDSDLFKNLPKKQTVWMSHSDKVENLPQGFEVLATSENSPFCVFGDEK
RKFFALQFHPEVQHSEFGKSILKNFAKYACNCDSVWNMGSFAKTQAQKIKEEVGNDKVLCAVSGGVDSSVVAALLASAIK
DQVVVVFVDNGLLRSGEKEQVEYMFKHTLGIDLISIDAREIFLSRLAGVRDPEQKRKIIGNTFIEVFEEEAKKHKDVKYL
AQGTLYTDIIESSVVGASKTIKSHHNVGGLPEKMNLKLIEPLKEIFKDEVRALGMELGLSKDVVYRHPFPGPGLAIRIMG
EVNEPSLELLRKADVILIEELKSSGWYDKTWQAFCVLLNVQSVGVMGDNRTYDNAVCVRVVNASDGMTATFSHLPYELLE
NISRRIINEVNGINRVVYDISSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-139 55
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-139 55
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-139 55
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-117 48