Gene Information

Name : Hlac_1546 (Hlac_1546)
Accession : YP_002566204.1
Strain :
Genome accession: NC_012029
Putative virulence/resistance : Resistance
Product : Cys/Met metabolism pyridoxal-phosphate-dependent protein
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 1566749 - 1567957 bp
Length : 1209 bp
Strand : +
Note : PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: hsl:OE2681F cystathionine synthase/lyase (cystathionine gamma-synthase, cystathionine gamma-lyase, cystathionine beta-lyase)

DNA sequence : 
ATGAGCGATCGATCCGACTCCCACGAGGGCGACGCCGACGACGAGGGCGACGCCGACGACCGCCGCTTCGAGACCCGCGC
GATCCACGCCGGACAGGAACCCGACCCGGAGACCGGCGCGCTGATGACACCAATTCACGCAAACTCCACGTATAAACAGG
ACGCGCCGGGCGAGCACCGCGGCTACGAGTACAGTCGAACCGGAAACCCGACTCGAACCGACCTCGAAGCCAACCTCGCC
TCGCTGGAATCGGGGAGTCACGCGCGCTGCTTCTCCTCCGGGATGGGCGCAATAAACACCGTCCTCAACCTGCTTGAGGC
GGGTGACCACGTCGTCGCCGGCGACGACGTGTACGGCGGGACCCACCGCATCCTCACGCAGGTGTACGAGCAGTACGACT
TGGAGACCACCTTCGTCGACACGACCGACCACGACGCGGTCCGGGATGCGATGCGTGAGGAGACGGAGTTAGTGTGGGTC
GAGACGCCGACGAACCCCCTGTTGAACGTCAACGACATCGGCGCACTTGCCGATATCGCCCACGAGGCAGATGCGCTCTG
CGCGGTCGACAACACGTTTGCGACCCCGTATCTCCAGCGCCCGCTCGAACACGGCGCCGACATCGTCTGCCAGTCGCTGA
CGAAGTACCTCGGCGGTCACTCCGACACCATCGGCGGGGCGCTCGTCGTCGACGACGCAGAACTGGACGAGCGGCTCGGC
TTCTACCAGAACTCGGTGGGCGCGACGCCCGGCCCGTTCGACTCCTTCCTCGTGTTACGCGGGACGAAGACGCTCCCGGT
CCGGATGGACCGCCACTGCGAGAACGCGATGGAACTGGCTCAGTGGTTAGAGGACCACGACGACGTGAGCCGCGTCTACT
ACCCCGGACTAGAGAGCCACCCGGACCACGACCTCGCGGCCGAGCAGATGGACGCCTTCGGCGGGATGCTCTCCTTCGAG
TTCGACGGCACCCTCGAACAGGGCTCGACAGTCGTCAGTGAGACGGAAGTGTTCACCCTCGCGGAGTCGCTCGGCGGCGT
CGAGAGCCTGATCGAGCAGCCGGCAGCGATGACCCACGCCGCGATCCCCCGCGAGGAGCGGCTCGCAGCCGGGCTCACGG
ACGGCCTCATTCGAGTGTCGGTGGGGATCGAGCACGTGGACGACATGAAGGCCGACTTCCAGCAGGCGTTCGACGCGGCG
CTGGAGTAG

Protein sequence : 
MSDRSDSHEGDADDEGDADDRRFETRAIHAGQEPDPETGALMTPIHANSTYKQDAPGEHRGYEYSRTGNPTRTDLEANLA
SLESGSHARCFSSGMGAINTVLNLLEAGDHVVAGDDVYGGTHRILTQVYEQYDLETTFVDTTDHDAVRDAMREETELVWV
ETPTNPLLNVNDIGALADIAHEADALCAVDNTFATPYLQRPLEHGADIVCQSLTKYLGGHSDTIGGALVVDDAELDERLG
FYQNSVGATPGPFDSFLVLRGTKTLPVRMDRHCENAMELAQWLEDHDDVSRVYYPGLESHPDHDLAAEQMDAFGGMLSFE
FDGTLEQGSTVVSETEVFTLAESLGGVESLIEQPAAMTHAAIPREERLAAGLTDGLIRVSVGIEHVDDMKADFQQAFDAA
LE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-84 49
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-83 49
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 1e-63 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Hlac_1546 YP_002566204.1 Cys/Met metabolism pyridoxal-phosphate-dependent protein BAC0207 Protein 8e-65 43