Gene Information

Name : guaA (AMF_897)
Accession : YP_002563978.1
Strain : Anaplasma marginale Florida
Genome accession: NC_012026
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1066097 - 1067686 bp
Length : 1590 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGTCTACCGTTGCCATAGTCGACTTTGGTTCCCAAGTAACCCAGCTTATAGCCAGAAGGGTTAGGGAGCTGGGTGTGTA
CAGTGAAGTATTTCCTCCCAGTACAGATTTTCAGGCTATGGCCAGCCGCGGAATCAAAATTGATGCCTTTATTCTCTCCG
GAGGCCCAAATTCGGTTCAGCAGTTGCATGGCGTTCCCAATGCAGTGTCAGACGTGCTGAATCTCAATCTCCAAAAAGGC
GTACCTGTGCTGGGTATATGCTACGGTTTTCAAATGCTGGCCCACTATTTTGGGGCTGACGTGGCACAGAGTGTAGCCAG
GGAATTTGGCAGAGCTTGGTTAGACGTCATTGAGCCCTCGTCTATCACTGAAGGGGTGTGGTCATTGGGCAGCAAGGTAG
ACGTGTGGATGAGCCACTCTGATAGCATAGTTGGTGAGGTGCCGCAGGGTTTTAGGGTGGTGGCGCGCAGCGCGGATACC
GGGGCTGTAGCGTTTATGTGTAATGATGAGCGCAAAATTTATGGTGTGCAGTTTCACCCAGAGGTGGCTCACACCCCGGG
TGGGCGTGAAATGCTAGACAACTTCTTAAAGATTGCAGGCTGCACCAGAGACTGGACTATGGGGTCATTCCTTCATACCC
AAATTGGCGCCATAAAGTCTGCTACTGACGGTGGACGCGTGGTGGCAGCGATCAGTGGCGGAGTTGATTCCAGCGTGGCA
TCAGTGTTGGTTCACAAGGCAATAGGGGAAAGGCTGGTTTGCGTATTTGTTGATACTGGCCTGCTGCGCAAAGGCGAGGC
TAGCGTGGTGCGAGACCTTTTCGTGGGCAAGCTCAACATGCATGTTAACGTTCTGGACAAAAGCGCCCTATTCATGCAAC
GTCTCGCTGGTGTGCAAGATCCAGAGGTAAAGCGTAAGATCATCGGCGAGACATTCATTGAGGTGTTCGAGCAAGAAGCT
AAGAGCCTAGGCGATATCAAATTCCTAATGCAGGGGACTATATACCCAGACGTTATAGAGTCTGGCGTAGGAGAATCTGG
AACAAAAATTAAATCACATCACAATGTCGGTGGGCTTCCTGAAATCATGAACTTGTCGCTCGTGGAGCCGCTTCGGCACC
TGTTTAAAGATGAAGTACGGTTACTGGGCAAAGAGCTTGGCTTGCCATCTGCGATACTCGATAGGCACCCGTTTCCGGGT
CCGGGGTTAGCGGTTAGGATTATGGGAGAGGTTACAGCAGAGCGGGTTGAGTTGCTGCGAGAAATAGACAACATCTACAT
AGATATGATGCGTGATAGTGGGTTGTATGACCACATATGGCAAGCGTTTGCGGTTTTGGTGCCCGTGCGTACCGTTGGTG
TGATGGGTGATGGCAGAACCTACGGGTATGTGTGTGCACTCAGGGCAGTCACCTCGAGTGATGGCATGACTGCAGACTGC
TTTCCCTTCGGTGAAACCGATGAAAGGAAGTTGGAGTTTCTTGCGTTTTTACAAAAAGTTAGTAGGGCTATTGTAAGCAA
TCTGCAGGGGGTGAATAGGGTTGTGTACGATATGACCTCAAAGCCCCCAGCAACGATTGAGTGGGAGTAA

Protein sequence :
MSTVAIVDFGSQVTQLIARRVRELGVYSEVFPPSTDFQAMASRGIKIDAFILSGGPNSVQQLHGVPNAVSDVLNLNLQKG
VPVLGICYGFQMLAHYFGADVAQSVAREFGRAWLDVIEPSSITEGVWSLGSKVDVWMSHSDSIVGEVPQGFRVVARSADT
GAVAFMCNDERKIYGVQFHPEVAHTPGGREMLDNFLKIAGCTRDWTMGSFLHTQIGAIKSATDGGRVVAAISGGVDSSVA
SVLVHKAIGERLVCVFVDTGLLRKGEASVVRDLFVGKLNMHVNVLDKSALFMQRLAGVQDPEVKRKIIGETFIEVFEQEA
KSLGDIKFLMQGTIYPDVIESGVGESGTKIKSHHNVGGLPEIMNLSLVEPLRHLFKDEVRLLGKELGLPSAILDRHPFPG
PGLAVRIMGEVTAERVELLREIDNIYIDMMRDSGLYDHIWQAFAVLVPVRTVGVMGDGRTYGYVCALRAVTSSDGMTADC
FPFGETDERKLEFLAFLQKVSRAIVSNLQGVNRVVYDMTSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-113 48
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 9e-114 48
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 7e-114 48
guaA NP_938969.1 GMP synthase Not tested Not named Protein 4e-109 47