Gene Information

Name : lysS (SUB0592)
Accession : YP_002561935.1
Strain : Streptococcus uberis 0140J
Genome accession: NC_012004
Putative virulence/resistance : Virulence
Product : lysyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : 6.1.1.6
Position : 557825 - 559315 bp
Length : 1491 bp
Strand : -
Note : class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA

DNA sequence :
ATGTCAAACGAACACATTGAAGAATTAAATGATCAACAAATTGTACGTCGTGAAAAAATGGTCGCTTTAGCAGAACAAGG
AATCGATCCTTTTGGAAAACGCTTTGAGCGTACTGCTACTTCTGCCGAATTAATCAACCAATTTGCTGATAAATCAAAAG
AAGAATTACATGACTTAGAAGAAACTGCTATCATTGCTGGTCGCCTTATGACCAAACGTGGTAAAGGAAAAGTTGGTTTT
GCCCATATCCAAGACAGAGATGGTCAAATTCAAATTTATGTCCGTAAAGATGCCGTCGGTGACGAAAATTATGAAATCTT
TAAAAAAGCAGATTTAGGAGATTTCCTAGGTGTTGAAGGTGACATTATGCGTACTGATATGGGAGAACTCTCTATCAAGG
CAACAAAATTAACGCATCTATCAAAAGCCTTACGCCCACTTCCAGAAAAATTCCATGGATTAACGGATATTGAAACCATA
TACCGTAAACGTCATCTAGACCTTATTTCAAATCGTGACAGCTTTAATCGCTTTGTTACACGTTCTAAAATGATTTCTGA
AATCCGTCGCTATTTAGATGGACTTAACTTCTTAGAAGTTGAAACACCAGTTCTCCATAATGAGGCAGGGGGCGCTGCTG
CTCGTCCATTTATAACACATCATAATGCTCAAAATATGGATATGGTATTGCGCATTGCAACTGAACTTCATTTGAAACGT
CTTATTGTCGGTGGAATGGAACGGGTTTATGAAATTGGTAGAATCTTCCGTAATGAAGGTATGGATGCTACCCATAATCC
TGAATTTACAACGATTGAAGTTTACCAAGCTTATGCTGATTTCCAAGATATCATGAACTTAACAGAAGGTATTATTCAAC
ACGCCGCTAAAGCCGTTAAAGGTGACGGTCCGATTGAATATCAAGGTCAAGTTATAAAGATTAATGAACCTTTCAAACGC
ATCCATATGGTTGATGCTATTAAAGAAGTTACAGGTGTTGATTTCTGGAAAGAAATGACAGTGGAAGAAGCCATTCAGTT
AGCACAAGAAAAACATGTCCCATTAGAAAAACATTTTACTAGCGTCGGACATATTATCAATGCATTCTTTGAAGAATTTG
TTGAAGAGACTTTAATTCAGCCAACCTTTGTTTTTGGTCATCCAGTTGAAGTTTCACCTCTAGCTAAGAAAAATCCAGAG
GATAATCGTTTCACCGACCGTTTTGAATTGTTTATTGTCACTAAAGAATATGCCAATGCCTTTACAGAATTAAATGATCC
AATTGACCAGCTGTCACGTTTTGAAGCTCAAGCGCAAGCAAAAGAGCTTGGGGATGATGAAGCTACTGGTATCGATTATG
ATTTCGTAGAAGCACTTGAATACGGAATGCCACCAACTGGTGGACTTGGAATTGGTATTGACCGACTTTGTATGTTGCTA
ACAGATACAACTACAATCCGTGATGTCCTCCTTTTCCCAACAATGAAATAA

Protein sequence :
MSNEHIEELNDQQIVRREKMVALAEQGIDPFGKRFERTATSAELINQFADKSKEELHDLEETAIIAGRLMTKRGKGKVGF
AHIQDRDGQIQIYVRKDAVGDENYEIFKKADLGDFLGVEGDIMRTDMGELSIKATKLTHLSKALRPLPEKFHGLTDIETI
YRKRHLDLISNRDSFNRFVTRSKMISEIRRYLDGLNFLEVETPVLHNEAGGAAARPFITHHNAQNMDMVLRIATELHLKR
LIVGGMERVYEIGRIFRNEGMDATHNPEFTTIEVYQAYADFQDIMNLTEGIIQHAAKAVKGDGPIEYQGQVIKINEPFKR
IHMVDAIKEVTGVDFWKEMTVEEAIQLAQEKHVPLEKHFTSVGHIINAFFEEFVEETLIQPTFVFGHPVEVSPLAKKNPE
DNRFTDRFELFIVTKEYANAFTELNDPIDQLSRFEAQAQAKELGDDEATGIDYDFVEALEYGMPPTGGLGIGIDRLCMLL
TDTTTIRDVLLFPTMK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD66193.1 putative lysil-tRNA synthetase LysU Not tested PAI III 536 Protein 4e-107 46

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
lysS YP_002561935.1 lysyl-tRNA synthetase VFG1668 Protein 2e-107 46