Gene Information

Name : pyk (SUB1000)
Accession : YP_002562326.1
Strain : Streptococcus uberis 0140J
Genome accession: NC_012004
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 975750 - 977252 bp
Length : 1503 bp
Strand : -
Note : catalyzes the formation of phosphoenolpyruvate from pyruvate

DNA sequence :
ATGAATAAACGCGTAAAAATTGTTGCAACACTTGGTCCTGCGGTAGAAATCCGTGGCGGAAAAAAATATGGAGAAGATGG
CTATTGGGCTGGTCAACTTGATGTTGAAGCATCAGCTAAAAAGATTGCTGAATTAATCGAAGCTGGCGCTAATGTTTTCC
GTTTCAATTTCTCACACGGCGACCACAAAGAACAAGGTGACCGTATGGCAACTGTAAGACGTGCAGAAGAAATGGCTCGT
CAAAAAGTAGCCTTTCTTTTAGATACTAAAGGTCCAGAAATGCGTACTGAATTATTTGCTGATGATGCAAAAGAATACAG
CTACACAACTGGTGAACGTATCCGTGTTACAACTGAGCAAGGAGTTCTATCAAGCCGTGATGTTATTGCGCTTAGCGTTG
CTGGTGGACTTGATATTTACGACGAAGTCGAAGTTGGACACACTATCCTTATCGATGATGGTAAATTAGGACTTAAAGTT
ATTGAAAAAGACATTGCAACTCGTCAATTTGTTGTTGAAGTTGAAAATGATGGGATTATTGCAAAACAAAAAGGTGTTAA
TATCCCTAACACAAAAATCCCATTCCCAGCTTTAGCAGAGCGTGACAATGCTGATATCCGTTTTGGTCTTGAACAAGGAC
TTAACTTTATCGCTATTTCATTTGTTCGTACTGCAAAAGATGTTGAAGAAGTTCGTCAAATCTGTCGTGAAACAGGTAAT
GAACACGTTCAATTGTTTGCTAAAATTGAAAACCAACAAGGTATTGATAATCTTGATGAAATCATTGAAGCTGCTGATGG
TATCATGATTGCCCGTGGTGACATGGGAATTGAAGTACCATTTGAAATGGTTCCAGTATTCCAAAAAATGATTATCACAA
AAGTAAATGCCGCTGGTAAAGCTGTTATCACAGCTACAAATATGCTTGAAACAATGACTGAAAAACCACGTGCAACACGC
TCAGAGGTTTCTGACGTCTTTAACGCTGTTATCGATGGTACAGACGCTACAATGCTTTCTGGTGAGTCTGCAAATGGTAA
ATACCCAGTTGAATCTGTTCGTACAATGGCTACAATTGATAAGAATGCTCAAACACTTCTTAACGAATATGGTCGTTTAG
ATTCTTCTAAATTCCCACGTACAAATAAAACAGATGTTATCGCATCAGCTGTTAAAGATGCTACACAGTCAATGGATATC
AAACTTGTTGTTACTATCACTGAAACTGGTAATACAGCACGTGCGATTTCTAAATTCCGTCCTGATGCTGACATCTTAGC
TGTTACTTTTGATGAAAAAGTTCAACGTGCTTTGATGATCTATTGGGGTGTTACTCCAGTTCTTGCAGAAAAACCATCTT
CTACAGATGATATGTTTGAAGTTGCTGAACAAGTTGCCCTTGAAACAGGTCTTGTTCAATCAGGTGATAATATTGTGATT
GTAGCTGGTGTTCCAGTAGGATCAGGCGGAACAAACACAATGCGCGTTCGTACCGTAAAATAA

Protein sequence :
MNKRVKIVATLGPAVEIRGGKKYGEDGYWAGQLDVEASAKKIAELIEAGANVFRFNFSHGDHKEQGDRMATVRRAEEMAR
QKVAFLLDTKGPEMRTELFADDAKEYSYTTGERIRVTTEQGVLSSRDVIALSVAGGLDIYDEVEVGHTILIDDGKLGLKV
IEKDIATRQFVVEVENDGIIAKQKGVNIPNTKIPFPALAERDNADIRFGLEQGLNFIAISFVRTAKDVEEVRQICRETGN
EHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVFQKMIITKVNAAGKAVITATNMLETMTEKPRATR
SEVSDVFNAVIDGTDATMLSGESANGKYPVESVRTMATIDKNAQTLLNEYGRLDSSKFPRTNKTDVIASAVKDATQSMDI
KLVVTITETGNTARAISKFRPDADILAVTFDEKVQRALMIYWGVTPVLAEKPSSTDDMFEVAEQVALETGLVQSGDNIVI
VAGVPVGSGGTNTMRVRTVK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 3e-83 43
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 3e-83 43
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 2e-83 43
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 8e-83 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pyk YP_002562326.1 pyruvate kinase VFG0479 Protein 1e-83 43