Gene Information

Name : thyA (MCCL_1078)
Accession : YP_002560481.1
Strain : Macrococcus caseolyticus JCSC5402
Genome accession: NC_011999
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : -
Position : 1187939 - 1188889 bp
Length : 951 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAATTCTTTTGACCTTGAATATCATAATTTATTAAAACTTATTTTAGAGACCGGTAAGGATAAGGATGATAGAACGAA
TACTGGGACATTGTCAGTTTTTGGACATCAGATGCGATTCGATCTTTCTAAAGGATTTCCATTGCTGACAACAAAGAAAG
TATCTTTCAAACTTGTAGCAACTGAACTTATCTGGTTTATCCGTGGGGATACGAATATCAGATACTTGCTTGAATATAAT
AACAATATATGGAACGAGTGGGCTTTCTTAAAGTGGATTGAAAGTGATGAATACATGGGTCCAGATATGACTGATTTTGG
TCATCGCGCATTGCGTGATCCTGAATTTAATGAACAGTATCGAGAGCAGCTGAATATTTTTAAAGAAAAGATTCTGACGG
ATGATGATTTTATGCAACGCTTTGGCGATCTCGGGAATGTTTACGGTAAACAGTGGCGTCAATTTGAAACGAAGGACCGC
GTGACTGATCAGCTGAAGGAAGTGATTGAACAGATTAAGTCCAATCCGCATAGTAGACGTCATATTGTATCAGCCTGGAA
CCCGGGAGAAATAGAGTCTATGGCACTGCCACCTTGTCACACGATGTTTCAGTTTTATGTGAATGATAATAAGCTTTCAT
GTCAACTGTATCAACGCAGTGCAGATGTATTTCTTGGCGTGCCTTTTAATATTGCAAGCTATAGCCTGCTTACACATTTA
GTTGCGAGAGAATGTGGGCTAGAAGTGGGTGAATTCATCCATTCTATGGGAGATGCACATATTTATTCGAATCACATCGA
AGCGGTTGAAACACAGTTGATGAGGTCATCGTATGAAGCACCTAAGCTTCAAATTAACAACGATAAGGATATATTTAATA
TTGAGTATGAAGATCTAGAAATAATCGATTACACAGCACATCCGGCGATTAAAGCGCCGATTGCAGTCTAA

Protein sequence :
MNSFDLEYHNLLKLILETGKDKDDRTNTGTLSVFGHQMRFDLSKGFPLLTTKKVSFKLVATELIWFIRGDTNIRYLLEYN
NNIWNEWAFLKWIESDEYMGPDMTDFGHRALRDPEFNEQYREQLNIFKEKILTDDDFMQRFGDLGNVYGKQWRQFETKDR
VTDQLKEVIEQIKSNPHSRRHIVSAWNPGEIESMALPPCHTMFQFYVNDNKLSCQLYQRSADVFLGVPFNIASYSLLTHL
VARECGLEVGEFIHSMGDAHIYSNHIEAVETQLMRSSYEAPKLQINNDKDIFNIEYEDLEIIDYTAHPAIKAPIAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 4e-116 74