Gene Information

Name : merA (trd_A0380)
Accession : YP_002523662.1
Strain :
Genome accession: NC_011961
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : 1.16.1.1
Position : 365005 - 366687 bp
Length : 1683 bp
Strand : -
Note : identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR02053

DNA sequence :
ATGACACCAGCGAACCACGAATCGGCCCTCGTCACGTACGAACTCGACGTGGAAGGGATGACCTGCCGGGATTGTGAGCG
GCACGTCGAGACAGCTGTCGAGGCCTCTGGCGGTATCGAGCCGCGAGCGGACTGGCGACGCCGTCGCGTCCGCTTCGCTG
CCCCGCCCACTTTCGACCCCCAACCTGTCTTCGCTGCCATTCGTGCTGCTAGCGGACAACTGCATCGGTACGAGCCAGGG
CAACTGCGGCGCCTGGCGCCTGTCCAGCTGGACGATGAGTCACCCGACGCTGATGCCGACCTGGTGATCATCGGCGGTGG
CTCAGCCGCCTTCGCTGCCGCGATCGAGGCCCACCAGCTCGGTGCCCGCGTCATCATGATCGAACGTGGCACGCTGGGTG
GAACCTGCGTCAACATCGGGTGCGTCCCCTCCAAGTTCTTGCTGCGTGCCGCCGAAGTCGCTCATCTGGCTGCGACGCGC
CGCTATCGCGGGATCCGCAGCCAACTCGAGGCAGTCGATCTGGCAGCCCATGTCGCGCAGAAGCAGGACCTGATCGCCGC
ACTGCGGCGCGAAAAGTACGAGGAACTCGTCGACTACTACGGTTGGGAACTCCTACACGGTACGGCCCGTTTCGTCGATC
CGCAGACAATCGCTGTCGGCGACCGCCTGATCCGCGCACGTGCCTTTCTGATCGCCACCGGGGCCAGTCCGGCTCTCCCG
CCGCTGCCTGGCCTCGCCGAGACGCCGTTCTTGACGAGCACGAGCGCGCTCGACCTGGAGCGCGTACCGACCTCGCTGCT
CGTGCTCGGTGCTGGGTACGTGGCCCTGGAACTCGGCCAAGCGTTCCAGCGGCTCGGCAGTCGCGTCACTCTCGTACAGC
GGCGAGCTCGGCTCTTGCCAGAAATCGAACTGAAGCTGGCCGAGCAACTCCAGCAGGCGCTCGCTGCGGAAGGGATCCGG
TTCCGCCTCGGCGTGCTCCCGCAGCGGGTCGAGCGCGTTCCTGGCGGCGTACGCCTCATCGTGCAGACCAGTGATGGTCG
CGAAGAAGCGCTCGAGGCTGAAACGCTGCTCGTGGCGACGGGACGCCGGCCGAACGTGGACGACCTCGATCTCGCTGCCG
CCGGTGTGGAACTCGACGCTCGGGGAGCCCCCAGACTCGATCCGACGCTCCGGACGACGAATCCCCGCATCTACGCCGCG
GGTGACGTGACGCTCGGCCCGCAGTTCGTGTATGTGGCAGCCGCGCAGGGCCGCCTGGCAGCTCGCAACGCGCTCCTCGG
AGAGCAGCAAATCCTGCGCCTCGATGCCGTACCAGCCGTCATCTTCACGCAGCCCCAGCTGGCCAGCGTCGGGCTGACCC
GAGCAGATGCCGAGGCGCGCGGGCATCGGGTCGTGACCGGCTTCGCTCCCGCGTCCGTGATCGCCCGCGAACGGGTCGAG
CTGCAACCGTTCGGCGGGGTGTTCCTGGTCGCTGATGCCGAGAGCGGGCGCATACTGGGTGTTCAGGCACTCGCCAGCGC
TGCCGGGGAACTGATCGAAGCAGCGACTCTGGCTGTCCATGCTGGGCTGACGCTCGCCGACCTCCGCGAGCATCTCGCCC
CCTACCTCACGGTTGGAGAGGGGCTGCGCTTAGCTGCGCTGGCTGTCGAGCAGGATCCCGCGCGCCTCTCATGTTGTGCG
TGA

Protein sequence :
MTPANHESALVTYELDVEGMTCRDCERHVETAVEASGGIEPRADWRRRRVRFAAPPTFDPQPVFAAIRAASGQLHRYEPG
QLRRLAPVQLDDESPDADADLVIIGGGSAAFAAAIEAHQLGARVIMIERGTLGGTCVNIGCVPSKFLLRAAEVAHLAATR
RYRGIRSQLEAVDLAAHVAQKQDLIAALRREKYEELVDYYGWELLHGTARFVDPQTIAVGDRLIRARAFLIATGASPALP
PLPGLAETPFLTSTSALDLERVPTSLLVLGAGYVALELGQAFQRLGSRVTLVQRRARLLPEIELKLAEQLQQALAAEGIR
FRLGVLPQRVERVPGGVRLIVQTSDGREEALEAETLLVATGRRPNVDDLDLAAAGVELDARGAPRLDPTLRTTNPRIYAA
GDVTLGPQFVYVAAAQGRLAARNALLGEQQILRLDAVPAVIFTQPQLASVGLTRADAEARGHRVVTGFAPASVIARERVE
LQPFGGVFLVADAESGRILGVQALASAAGELIEAATLAVHAGLTLADLREHLAPYLTVGEGLRLAALAVEQDPARLSCCA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 6e-84 44
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 5e-84 44
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 9e-57 44
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 1e-49 44
merA ABQ57371.1 MerA Not tested SGI1 Protein 5e-53 43
merA AGK07021.1 MerA Not tested SGI1 Protein 5e-53 43
merA AGK07079.1 MerA Not tested SGI1 Protein 5e-53 43
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 2e-52 43
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 3e-54 43
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 4e-54 43
merA AFG30120.1 MerA Not tested PAGI-2 Protein 3e-54 43
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 2e-52 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
merA YP_002523662.1 mercuric reductase BAC0224 Protein 1e-88 48
merA YP_002523662.1 mercuric reductase BAC0651 Protein 3e-84 44
merA YP_002523662.1 mercuric reductase BAC0652 Protein 2e-53 43
merA YP_002523662.1 mercuric reductase BAC0653 Protein 1e-49 43
merA YP_002523662.1 mercuric reductase BAC0650 Protein 3e-52 42