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Name : ureC (trd_0531) Accession : YP_002521777.1 Strain : Thermomicrobium roseum DSM 5159 Genome accession: NC_011959 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 529000 - 530700 bp Length : 1701 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGCCGGTCCGGATCGACCGTCAACACTATGCTCGTTGGTACGGCCCCACAGCGGGCGACCGCATCCGGCTCGCCGACAC CAACCTGTACGCTCGTATCGAGCGGGACGACACCCTGCCCGGCTTCGAACCGCTCGTCGGCTTCGGTCGTCCTGTCCGCG ACGGCATGCTGGCCGGGCGCGACCACGGCCCCAGCAAGCTCGATCTCGTCATCACGAACGTCGTCGTGATGGACCCGGTA CTCGGCATCTTCAAGAGCAACATCGGCATCAAGGACGGTCGTATCGTCGCGATCGGCCGGGCCGGGAATCCGGACGTCAT GGAGGACGTCGAGGTTCTCATCAGCAATGCTACTGGAATCATCCCGGCTGAGGGACTGATCGCCACGCCCGGCGGGGTCG ATGCCCATGTGCACCTCTCTTCCACAAGCGTCGTCCCCGCTGCTCTCAGCGCCGGCATCACGACGCTCGTCGCGCAGGGA TCCGGCGGTGTCTGGGATCTGGGTGTCAATCCCGTGAACAATCTGCGTCATCTCTTGGAAGCATTCGAGACGATCCCGCT GAACCTCGCCGTGCTCGGTCGCGGCTCCTCCGACACCGCACAACTTGTCGAGCACCTGGAAGCCGGCTGCGCGGGATTCA AGATCCACGAAGATGTCGGCGCTTTCCCAGCAGTCATCGATGCGTGCCTGACCATCGCCGACCAGGCTGGTGTGCAGGTT GCCCTGCACACCGACGGATTGAACGAGGCTGGGTCACTGCGAGAGACGATCGCCGCGATCGCTGGGCGCTCCATTCACGC GTACCACGTAGAGGGATCCGGCGGCGGCCACGCACCCAATATCCTGGAGATCGTCTCGGAGCCGAACGTCATCGGTTCGT CGACGAGCCCGACGATTCCCTATTCCGTCAACAGTACGGCTGAGTTGCTCGATATGATTATCGCTGTCCATCGCCTGGCC ACTGATATCCCGAGCGACCTCGCCGCCGCGCGCGATCGAGTACGAGCGAGCACGATCGCCGCGGAAGATGTGCTCCACGA TCTCGGTGCCATTGCCATCATGTCCTCCGACTCGCAAGGGATGGGGCGGATCGGCGAAGTGATCACCCGGACCTGGCAAC TGGCTCATCGCATGAAGGAGATTCGCGGCGGTGGCTACGACCCTGCATCCGGGAACGGCGATGACAACCCGCGCATCCTG CAGTACTTGGCGAAGTACACCATCAATCCAGCCATCGCGCACGGACTGGATCACGAAGTCGGAAGCCTCGAACCGGGCAA GCTCGCCGACATCGTCCTCTGGCATCCCGCCTTTTTCGGAGCCAAACCCGCTGCGGTCATCAAGGCTGGCTTCGTCGCCT GGGCACCTGTCGGCGACGGAATGGGCTCCACACGCTGGAGTCAACCGTTGATCTACCGACCGATGTTCGGGGGACTCGGA CGAGCTCCGGCTGCACTGAGCGTTGCCTTCGTCGCACCAGTTGCCGCCACATCGAGTCACCTCGAGCGCAGTGGACTGCA ACGCCGCCTCGTAGCCGTCCGCAATGTCCGCCGTGTCTTCAAAAACGCCATGCGCTATAACACCGCCTCACCCCGTGTCG AGGTCGACCCGCGCACCTATGCGGTCGCGATCAACGGCCAAGTGGTCGAGATTCCACCAGCGGAGCGCTTGCCTCTCACG TTTTTGCATTTCATCGCTTGA Protein sequence : MPVRIDRQHYARWYGPTAGDRIRLADTNLYARIERDDTLPGFEPLVGFGRPVRDGMLAGRDHGPSKLDLVITNVVVMDPV LGIFKSNIGIKDGRIVAIGRAGNPDVMEDVEVLISNATGIIPAEGLIATPGGVDAHVHLSSTSVVPAALSAGITTLVAQG SGGVWDLGVNPVNNLRHLLEAFETIPLNLAVLGRGSSDTAQLVEHLEAGCAGFKIHEDVGAFPAVIDACLTIADQAGVQV ALHTDGLNEAGSLRETIAAIAGRSIHAYHVEGSGGGHAPNILEIVSEPNVIGSSTSPTIPYSVNSTAELLDMIIAVHRLA TDIPSDLAAARDRVRASTIAAEDVLHDLGAIAIMSSDSQGMGRIGEVITRTWQLAHRMKEIRGGGYDPASGNGDDNPRIL QYLAKYTINPAIAHGLDHEVGSLEPGKLADIVLWHPAFFGAKPAAVIKAGFVAWAPVGDGMGSTRWSQPLIYRPMFGGLG RAPAALSVAFVAPVAATSSHLERSGLQRRLVAVRNVRRVFKNAMRYNTASPRVEVDPRTYAVAINGQVVEIPPAERLPLT FLHFIA |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 1e-115 | 49 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 1e-115 | 49 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-104 | 46 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 6e-105 | 46 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 6e-105 | 46 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 6e-105 | 46 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_002521777.1 | urease subunit alpha | VFG0270 | Protein | 4e-107 | 45 |
