Gene Information

Name : trd_0272 (trd_0272)
Accession : YP_002521526.1
Strain : Thermomicrobium roseum DSM 5159
Genome accession: NC_011959
Putative virulence/resistance : Resistance
Product : macrolide-specific ABC-type efflux carrier
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG1136
EC number : -
Position : 279298 - 280035 bp
Length : 738 bp
Strand : +
Note : identified by match to protein family HMM PF00005

DNA sequence : 
ATGGGCACCACCCGAGAACAGGAGCGAACTCCGATCGTCGAGGCAACGAACGTCGTGAAGATCTACGACACGGGACGCGT
GAAGGTTCCGGCATTGCGCGGCGTTTCGCTGACCGTGTACGGAGGCGAAATGGTCGCGATCATGGGGCCCTCCGGAAGCG
GGAAGACGACACTCCTCAACTGTCTTTCTGGCCTCGATACGATCGACGAGGGGATGATTCTGATCGCGGGGAAAGAGCTC
GCGCGCCTACCGGACGATGTCCGATCGGAATTCCGCGCTCGTCATATGGGTTTCGTTTTCCAGCTGTTCAATCTCATTCC
GGTCTTGAGTGCCTTGGAGAACGTCGAACTTCCCGCGCTTTTGGCGGGTATACGGCCGAGCGAGGCGAGACGGCGCGCGT
GGGCAGTGCTCGAGCAAGTTGGTTTGGCTGACCGGGCTGGGCATAAGCCGGCCGAGCTATCGGGAGGCCAGCAGCAGCGG
GTGGCGATCGCTCGTGCCCTGGTCAACCAGCCGGATATCATCTGGGCCGATGAGCCAACCGGGAACTTGGACACGGAGAC
GGCTGACGAGGTCATGGCGTTGCTGCGCCGGCTGAACCGCGAGAATGGCCAGACCTTCGTCATCGTGACCCATGATCCGC
GGATCGGCTCGATGTGTGACCGCGTGATCCAGATGCGCGATGGGTTGATCATCGACGATGGACTCGCTTCCTTCCGCGCA
GCTGCTGGCGGGGAGTGA

Protein sequence : 
MGTTREQERTPIVEATNVVKIYDTGRVKVPALRGVSLTVYGGEMVAIMGPSGSGKTTLLNCLSGLDTIDEGMILIAGKEL
ARLPDDVRSEFRARHMGFVFQLFNLIPVLSALENVELPALLAGIRPSEARRRAWAVLEQVGLADRAGHKPAELSGGQQQR
VAIARALVNQPDIIWADEPTGNLDTETADEVMALLRRLNRENGQTFVIVTHDPRIGSMCDRVIQMRDGLIIDDGLASFRA
AAGGE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
Cp1002_1464 YP_005681730.1 ABC transporter ATP-binding protein Not tested PiCp 5 Protein 2e-35 46
CpC231_1466 YP_005683828.1 ABC transporter ATP-binding protein Not tested PiCp 5 Protein 4e-37 45
cpfrc_01473 YP_003783873.1 hypothetical protein Not tested PiCp 5 Protein 4e-37 45
CpI19_1473 YP_005685914.1 ABC transporter ATP-binding protein Not tested PiCp 5 Protein 4e-37 45
cur_1502 YP_001800896.1 cell division ATP-binding protein FtsE Not tested Not named Protein 6e-28 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
trd_0272 YP_002521526.1 macrolide-specific ABC-type efflux carrier NC_012469.1.7686878. Protein 2e-44 48
trd_0272 YP_002521526.1 macrolide-specific ABC-type efflux carrier NC_008702.1.4606598. Protein 8e-40 48
trd_0272 YP_002521526.1 macrolide-specific ABC-type efflux carrier CP001581.1.gene798.p Protein 2e-40 45
trd_0272 YP_002521526.1 macrolide-specific ABC-type efflux carrier CP001581.1.gene598.p Protein 1e-39 43
trd_0272 YP_002521526.1 macrolide-specific ABC-type efflux carrier NC_012469.1.7685735. Protein 7e-38 42