Gene Information

Name : polA (SPN23F_00490)
Accession : YP_002510134.1
Strain : Streptococcus pneumoniae ATCC 700669
Genome accession: NC_011900
Putative virulence/resistance : Unknown
Product : DNA polymerase I
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0749
EC number : 2.7.7.7
Position : 39119 - 41752 bp
Length : 2634 bp
Strand : +
Note : has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair

DNA sequence :
ATGGATAAGAAAAAATTATTATTGATTGATGGGTCTTCTGTAGCTTTTCGGGCGTTTTTTGCGCTGTATCAGCAGTTGGA
CCGTTTTAAGAATGCGGCTGGTTTGCATACCAATGCGATTTATGGTTTTCAGTTGATGTTGAGTCATTTGTTGGAGCGGG
TTGAGCCGAGTCATATTTTGGTGGCTTTTGATGCGGGAAAGACGACCTTCCGGACAGAGATGTATGCGGACTATAAGGGT
GGTCGGGCCAAGACTCCTGATGAGTTTCGTGAGCAATTTCCTTTCATTCGTGAGTTGCTGGATCATATGGGGATTCGTCA
CTATGAGCTCGCTCAGTATGAGGCGGATGACATCATTGGGACGCTGGATAAGCTAGCAGAGCAGGATGGTTTTGATATTA
CCATTGTCAGTGGGGACAAGGATTTGATTCAGCTGACGGATGAGCATACGGTGGTTGAAATTTCCAAGAAAGGTGTGGCT
GAGTTTGAGGCCTTTACGCCAGATTACCTCATGGAAGAAATGGGCCTCACACCAGCTCAGTTTATCGATCTCAAGGCGCT
CATGGGTGATAAGTCGGATAATATCCCTGGGGTGACCAAAGTCGGTGAAAAGACGGGTATTAAGCTCTTGCTGGAGCATG
GTTCGCTTGAGGGGATTTATGAAAATATTGATGGAATGAAGACTTCTAAGATGAAGGAAAATCTCATCAATGACAAGGAA
CAGGCCTTTTTGTCTAAAACACTAGCGACCATTGATACCAAGGCACCGATTGCGATTGGTTTAGAGGACTTGGTCTATAG
TGGTCCAGATGTTGAAAATCTTGGGAAATTTTACGATGAGATGGGATTCAAACAGCTCAAGCAGGCTTTAAATATGTCGT
CAGCTGATGTGGCTGAGGGTTTGGATTTTACTATTGTTGACCAAATCAGTCAAGATATGCTGAGTGAAGAGTCTATCTTC
CACTTTGAGCTTTTTGGTGAGAATTACCATACAGATAATTTGGTTGGATTTGCCTGGTCTTGTGGGGATCAGCTCTATGC
CACAGACAAGCTTGAGCTGTTGCAAGACCCGATTTTCAAGGATTTCTTAGAAAAAACATCTCTGAGAGTTTATGACTTTA
AGAAGGTTAAAGTTCTTTTGCAACGTTTTGGTGTAGATTTGCAGGCGCCTGCTTTTGACATCCGTTTGGCTAAATACCTC
CTTTCGACTGTGGAGGACAATGAAATTGCGACCATCGCTAGTCTTTATGGTCAGACTTACTTGGTTGATGATGAAACTTT
CTACGGTAAGGGTGTTAAAAAGGCCATTCCTGAACGTGAGAAATTCTTGGAACACTTAGCTTGTAAACTTGCTGTTTTGG
TAGAAACAGAGCCTATTTTACTTGAAAAACTCAGCGAAAATGGGCAATTAGAGCTTCTTTATGATATGGAGCAACCTCTG
GCTTTTGTCCTTGCCAAGATGGAAATTGCTGGAATTATGGTTAAGAAAGAGACCTTGCTTGAGATGCAGGCTGAAAATGA
GCTTGTCATTGAAAAACTGTCTCAAGAGATTTACGAGCTGGCTGGTGAGGAGTTTAATGTCAACTCGCCTAAGCAGTTGG
GCGTGCTTCTCTTTGAGAAATTGGGACTTCCTCTAGAATACACTAAGAAAACCAAGACAGGTTATTCGACAGCAGTGGAT
GTTTTGGAGCGTCTCGCTCCTATTGCTCCGATTGTTAAGAAAATCCTGGATTACCGTCAAATTGCTAAGATTCAATCTAC
TTATGTAATTGGCTTGCAGGACTGGATTTTGGCTGATGGAAAGATTCATACTCGCTATTTGCAGGATTTGACCCAGACCG
GGCGTTTGTCTAGTGTGGATCCAAACTTGCAAAATATTCCTGCCCGATTGGAACAGGGGCGCTTGATTCGGAAGGCTTTT
GTGCCAGAGTGGGAGGATAGTGTGCTACTCAGCTCTGACTATTCACAGATTGAATTGCGCGTTTTGGCGCATATTTCTAA
GGATGAGCACTTGATTAAGGCCTTCCAAGAGGGGGCAGATATCCATACTTCGACAGCCATGCGGGTCTTTGGCATTGAGC
GTCCTGATAATGTGACTGCAAATGACCGTCGTAATGCCAAGGCAGTTAACTTTGGAGTGGTTTATGGGATTTCAGACTTT
GGCTTGTCTAATAATTTGGGAATTAGTCGTAAGGAAGCCAAAGCCTACATTGATACCTACTTTGAACGTTTTCCAGGTAT
TAAAAACTACATGGATGAAGTGGTGCGGGAGGCGCGTGATAAGGGCTATGTAGAGACCCTCTTTAAGCGTCGCCGTGAGT
TGCCAGATATCAATTCGCGCAACTTCAATATTCGTGGTTTTGCGGAGCGAACTGCTATCAACTCACCTATCCAGGGTTCG
GCAGCAGATATTCTCAAGATTGCCATGATTCAGCTGGATAAAGCCTTGGTTGCAGGTGGTTATCAGACTAAGATGCTGTT
ACAAGTGCACGATGAAATCGTCCTTGAAGTGCCTAAATCTGAATTGGTAGAGATGAAAAAATTGGTGAAACAAACCATGG
AAGAAGCCATTCAACTCAGTGTTCCTCTTATCGCAGATGAGAATGAAGGAGCAACCTGGTACGAGGCTAAATAA

Protein sequence :
MDKKKLLLIDGSSVAFRAFFALYQQLDRFKNAAGLHTNAIYGFQLMLSHLLERVEPSHILVAFDAGKTTFRTEMYADYKG
GRAKTPDEFREQFPFIRELLDHMGIRHYELAQYEADDIIGTLDKLAEQDGFDITIVSGDKDLIQLTDEHTVVEISKKGVA
EFEAFTPDYLMEEMGLTPAQFIDLKALMGDKSDNIPGVTKVGEKTGIKLLLEHGSLEGIYENIDGMKTSKMKENLINDKE
QAFLSKTLATIDTKAPIAIGLEDLVYSGPDVENLGKFYDEMGFKQLKQALNMSSADVAEGLDFTIVDQISQDMLSEESIF
HFELFGENYHTDNLVGFAWSCGDQLYATDKLELLQDPIFKDFLEKTSLRVYDFKKVKVLLQRFGVDLQAPAFDIRLAKYL
LSTVEDNEIATIASLYGQTYLVDDETFYGKGVKKAIPEREKFLEHLACKLAVLVETEPILLEKLSENGQLELLYDMEQPL
AFVLAKMEIAGIMVKKETLLEMQAENELVIEKLSQEIYELAGEEFNVNSPKQLGVLLFEKLGLPLEYTKKTKTGYSTAVD
VLERLAPIAPIVKKILDYRQIAKIQSTYVIGLQDWILADGKIHTRYLQDLTQTGRLSSVDPNLQNIPARLEQGRLIRKAF
VPEWEDSVLLSSDYSQIELRVLAHISKDEHLIKAFQEGADIHTSTAMRVFGIERPDNVTANDRRNAKAVNFGVVYGISDF
GLSNNLGISRKEAKAYIDTYFERFPGIKNYMDEVVREARDKGYVETLFKRRRELPDINSRNFNIRGFAERTAINSPIQGS
AADILKIAMIQLDKALVAGGYQTKMLLQVHDEIVLEVPKSELVEMKKLVKQTMEEAIQLSVPLIADENEGATWYEAK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
polA YP_281523.1 DNA polymerase I Not tested Not named Protein 0.0 73