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Name : leuS (MLBr_00032) Accession : YP_002502787.1 Strain : Mycobacterium leprae Br4923 Genome accession: NC_011896 Putative virulence/resistance : Unknown Product : leucyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG0495 EC number : 6.1.1.4 Position : 36317 - 39235 bp Length : 2919 bp Strand : + Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl DNA sequence : GTGACTGAACTGCCGACCACTGTCCCTGGGTACAACTCGGCTGTTGCCCAGACGGACTCCGATGCGATGCGATACCGCTA TACCGCGGAGCTAGCAGGCCGTATCGAAAGCACCTGGCAAGACAACTGGGCGCGGCTGCAGACCTTCAACGTGCCCAACC CGGTTGGGTCGCTAGCCCCGCCGGACGGATCGGTAGTTCCCGCCGACAAGTTGTTCGTACAGGACATGTTTCCCTATCCA TCGGGTGACGGATTGCATGTTGGACATCCACTAGGTTACATCGCCACCGACGTCTACGCTCGATACTTCCGTATGACCGG TCATAACGTGCTGCACGCGATGGGGTTCGATGCTTTCGGGCTGCCCGCCGAACAGTACGCGATGCAAACCGGAACCCACC CACGCATTCTAACTGAGGCTAACGTTGTCAACTTTCGGCACCAGCTGGGCCGGTTGGGTCTTGGCCACGACAGCCGACGC ACCTTCTCGACCACCGATGTCGAGTTCTACAAGTGGACCCAGTGGATTTTCCTGCAGATCTACAACGCTTGGTTCGACGT AGCAGCTAACAAGGCGCGCCCGATCGCAGAATTGATTGCCGAATTCGATTCCGGTGAGCGCCGCCTTGTTGACGGCCGTG ACTGGGCCACGTTGTCGGCCGGGGAGCGGGCCGACGTGATCGACAACTGTCGACTGGTCTACCGGGCGGACTCGATGGTC AACTGGTGTCCGGGTCTGGGCACGGTACTGGCCAACGAAGAGGTCACCGCCGACGGTCGCAGCGACCGCGGCAACTTCCC GGTATTCCGGAAACGTTTGAGGCAATGGATGATGCGGATCACCGCCTACGCTGACCGGTTGCTGGACGACCTTGACCTGC TGGACTGGCCGGAGCAAGTCAAAACTATGCAGCGCAACTGGATCGGCCGTTCCAGCGGAGCGACCGTGCTGTTCTCAGCG ATCCTAAGCCGCAGCGATGCCGCGACAACCGAAGTCGACGTCGAGGTGTTCACCACCCGGCCGGACACCATGTTTGGCGT CACCTATCTGGTGCTGGCACCCGAGCACAACCTGGTCGACGAACTGGTTGCCACCGTCTGGCCGGACAGGACGGACCCCC GGTGGACGTATGGTGCCGCCACGCCAGGTGCAGCTGTCGCAGCCTACCGCCGTGCAATCGTTGCCAAGTCGGACCTCGAT CGCCAAGAGAGCAAGGAGAAGACCGGCGTCTTCTTGGGTAGGTACGCCACCAACCCAGCCACCGGAAAACCGGTGCCGAT TTTCGTTGCCGACTATGTACTGGTCGGCTATGGTACCGGTGCGGTCATGGCGGTTCCCGGCCATGACCCGCGTGACTGGG ACTTCGCCCATAAGTTCCATTTGCCGATCGTCGAAGTTATTGCTGGAAGCGATATTTCAGAGGCCGCCTATGTGGGCGAT GGTGTGTTGGTGAACTCCGGTTACCTCGACGGTATGGACGTGGCAACAGCCCAAGAGGCCATTACCGCCCGCTTGGAGTC CGAAGGTCGAGGACATGCTCGCATCGAATTCAAGCTAAGAGACTGGCTTTTCGCTCGGCAGCGGTATTGGGGTGAGCCGT TCCCAATAATCTATGATAGTGACGGACGACCGCATGCGCTAGACGAGGCCGCACTGCCGGTTGAGCTTCCCGACGTACCG TACTACTCTCCGGTGTTATTCGATCCTGATGATGCTGACAGCGAGCCATCACCTCCGCTGGCCAAGGCGACCGAGTGGGT GCACGTAGAGTTGGATCTGGGCGACGGTTTGAAGCCTTACAGCCGCGACACCAATGTCATGCCACAGTGGGCGGGCAGCT CTTGGTACGAACTGCGTTACACCGATCCACACAACTCAGAGCGGCTCTGTGCCAAGGAAAACGAGGCCTATTGGATGGGT CCACGGCCGACTGAACACGGCATCGACGATCCCGGCGGCGTTGATTTGTACGTCGGCGGAGCCGAACATGCGGTGCTACA TCTGTTGTATGCGAGGTTTTGGCACAAAGTTCTATACGATCTGGGCCACGTCAGCTCTCGAGAACCCTACCGTAGGCTGA TCAACCAGGGCTACATCCAGGCTTTCGCTTACACTGATGCTCACGGTTCATATGTGCCGGCGAACCAGGTATTCCAACGC GGCGACGGGTTCTTCTGTCCGGGACCCGACGGCGAGATCGAAGTCTTCCAAGAGTTTGGGAAAATCGGTAAAAGCTTGAA GAATTCGGTATCACCTGACGAAATCTGCGATGAATACGGTGCAGACACGTTGCGTGTGTATGAAATGTCAATGGGGCCGT TGGAGGCGTCCCGACCGTGGGCCACGAAGGACGTCGTTGGCGCATATCGTTTCCTTCAGCGGGTGTGGCGACTGGTGGTA GATGAACGCACTGGTGAAACCCGGGTGGTGGACACAGCAGGGGAGTTAGATACTTACACGTTGCGAACATTGCACCGCAC CATCGCAGGAGTGTCCCAAGACTATGCTGCACTGCGCAATAACACCGCAACGGCGAAGCTGATCGAGTACACCAACCATC TCACCAAAGAACACCGTGGCTCGGTGCCCCGGGTCGCTGTCGAGCCTCTTGTGTTGATGTTGGCGCCGCTAGCCCCACAT CTGGCAGAAGAGCTGTGGCTGCGGCTGGGCCACACCACCTCTTTGGCGAACGGCCCTTTTCCCCAGGCCGATCCCGCCTA CCTTGTTGACGATACCGTTGAATACCCGGTGCAGGTGAACGGCAAGATTCGGGGTCGGATAGTGGTTGCCGCCGACGCGG ACTACGACACCCTGAAAACTGTTGCGTTGGCTGACGATAAAGTACAGCAGTTTTTGGCCGGTGCTACACCGCGCAAAGTG ATTGTGGTCGCGGGCCGGCTGATCAGTTTAGTCATTTAA Protein sequence : MTELPTTVPGYNSAVAQTDSDAMRYRYTAELAGRIESTWQDNWARLQTFNVPNPVGSLAPPDGSVVPADKLFVQDMFPYP SGDGLHVGHPLGYIATDVYARYFRMTGHNVLHAMGFDAFGLPAEQYAMQTGTHPRILTEANVVNFRHQLGRLGLGHDSRR TFSTTDVEFYKWTQWIFLQIYNAWFDVAANKARPIAELIAEFDSGERRLVDGRDWATLSAGERADVIDNCRLVYRADSMV NWCPGLGTVLANEEVTADGRSDRGNFPVFRKRLRQWMMRITAYADRLLDDLDLLDWPEQVKTMQRNWIGRSSGATVLFSA ILSRSDAATTEVDVEVFTTRPDTMFGVTYLVLAPEHNLVDELVATVWPDRTDPRWTYGAATPGAAVAAYRRAIVAKSDLD RQESKEKTGVFLGRYATNPATGKPVPIFVADYVLVGYGTGAVMAVPGHDPRDWDFAHKFHLPIVEVIAGSDISEAAYVGD GVLVNSGYLDGMDVATAQEAITARLESEGRGHARIEFKLRDWLFARQRYWGEPFPIIYDSDGRPHALDEAALPVELPDVP YYSPVLFDPDDADSEPSPPLAKATEWVHVELDLGDGLKPYSRDTNVMPQWAGSSWYELRYTDPHNSERLCAKENEAYWMG PRPTEHGIDDPGGVDLYVGGAEHAVLHLLYARFWHKVLYDLGHVSSREPYRRLINQGYIQAFAYTDAHGSYVPANQVFQR GDGFFCPGPDGEIEVFQEFGKIGKSLKNSVSPDEICDEYGADTLRVYEMSMGPLEASRPWATKDVVGAYRFLQRVWRLVV DERTGETRVVDTAGELDTYTLRTLHRTIAGVSQDYAALRNNTATAKLIEYTNHLTKEHRGSVPRVAVEPLVLMLAPLAPH LAEELWLRLGHTTSLANGPFPQADPAYLVDDTVEYPVQVNGKIRGRIVVAADADYDTLKTVALADDKVQQFLAGATPRKV IVVAGRLISLVI |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| leuS | YP_281511.2 | leucyl-tRNA synthetase | Not tested | Not named | Protein | 2e-134 | 46 |
