Gene Information

Name : guaB1 (MLBr_02066)
Accession : YP_002504008.1
Strain : Mycobacterium leprae Br4923
Genome accession: NC_011896
Putative virulence/resistance : Unknown
Product : inosine 5-monophosphate dehydrogenase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0516
EC number : -
Position : 2453625 - 2455061 bp
Length : 1437 bp
Strand : +
Note : catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate

DNA sequence :
ATGAGGTTTCTGGACGGGCACCAGCCCAGGTTCGACCTAACCTATAAAGACGTTTTCATCGTGCCACACCGGTCGGATGT
TGCGTCGCGATTTGACGTCGATTTGTCAACCTATGACGGCTCCGGCACCACTATTCCCGTAGTGGTCGCCAACATGACCA
CGGTGGCCGGGCAACGGATGGCAGAGACGGTAGCTCGCCGGGGCGGCTTAGTAATTTTACCGCAGGATCTGCCGATTGCA
ACAGTGCAGCAGGCAGTGGAGTTCGTCAAGAGCCGTGACCTGGTTATCGATACCCCGGTGTTACTGACACCTAACGATTC
GGTGTCCGACGCGACCACACTGATCCACAAGCGCGCGCACGGTGTTGCGGTGGTGGCCTTCGAAGGCCGCCCAATTGGTC
TGGTGCGCGAATCGTCTTGCCTAGGTGTGGACCGCTTCACTCGGGTGCGGGATGTCGCGACTACCGACTTTGTAACCGCC
CCGGTGGGCACCGATCCACGCAAGATCTTCGACCTGCTCGAACATGCCCCGATCGACGTCGCGGTGCTGACTAACGCCGA
CGGCACGCTGGCCGGAGTACTGACCCGCACCGGGGCGATCCGCGCCGGCATCTACACCCCAGCCACCGATGCCCGCGGAC
GGCTCCGCATCGGTGCTGCTGTCGGCATAAACGGCGATGTAGCCGGCAAGGCCCAGTCCCTCGCCGAGGCAGGTGTCGAT
GTGCTGGTCGTCGACACCGCACACGGATACCAAGTCAAGACACTCGAGGCGATCAAATGCGTCGCATCGCTGAACTTGGG
TGTGCCGTTGGTCGCGGGCAACGTGGTGTCGGCTGAAGGTACTCGCGAGCTACTCAACGCCGGGGCGACCATCGTCAAGG
TCGGCGTCGGCCCAGGAGCAATGTGCACAACTCGGATGATGACCGGTGTTGGCCGACCGCAATTCTCAGCTGTACTCGAA
TGTGCCTCTGCTGCAAGGAAACTCAATAGGCACGTGTGGGCTGATGGAGGAGTCCGCCATCCGCGTGACGTGGCGCTGGC
GTTGGCCGCAGGAGCATCGAACGTGATGATCGGGTCGTGGTTCGCCGGGACTTATGAGTCACCCGGGGACCTCATGCGGG
ACCGCCACGACCAACCGTACAAGGAAAGCTACGGCATGGCGTCCAAGCGAGCGGTGGTTGCCCGCACCGTTGCCGACAGC
TCATTCGATCGCGCTCGCAAGGCGTTATTCGATGAAGGCATCTCGACCTCACGGATGGGGCTGGATCCCGACCACGGTGG
TGTCGAGGACCTGATCGATCACATCACCTCCGGCGTGCGCAGCACCTGCACCTATGTCGGCGCGTCGACCCTGGCGGAGC
TGCATGAGAAGGCTGTCGTCGGGGTGCAGTCAGCGGCGGGTTTCGCCGAGGGCCATCCACTGCCCTCGGGGTGGTGA

Protein sequence :
MRFLDGHQPRFDLTYKDVFIVPHRSDVASRFDVDLSTYDGSGTTIPVVVANMTTVAGQRMAETVARRGGLVILPQDLPIA
TVQQAVEFVKSRDLVIDTPVLLTPNDSVSDATTLIHKRAHGVAVVAFEGRPIGLVRESSCLGVDRFTRVRDVATTDFVTA
PVGTDPRKIFDLLEHAPIDVAVLTNADGTLAGVLTRTGAIRAGIYTPATDARGRLRIGAAVGINGDVAGKAQSLAEAGVD
VLVVDTAHGYQVKTLEAIKCVASLNLGVPLVAGNVVSAEGTRELLNAGATIVKVGVGPGAMCTTRMMTGVGRPQFSAVLE
CASAARKLNRHVWADGGVRHPRDVALALAAGASNVMIGSWFAGTYESPGDLMRDRHDQPYKESYGMASKRAVVARTVADS
SFDRARKALFDEGISTSRMGLDPDHGGVEDLIDHITSGVRSTCTYVGASTLAELHEKAVVGVQSAAGFAEGHPLPSGW

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
CpC231_1472 YP_005683835.1 Inosine 5-monophosphate dehydrogenase Not tested PiCp 5 Protein 3e-134 58
CpI19_1479 YP_005685921.1 Inosine 5-monophosphate dehydrogenase Not tested PiCp 5 Protein 3e-134 58
cpfrc_01479 YP_003783879.1 hypothetical protein Not tested PiCp 5 Protein 2e-134 58
Cp1002_1469 YP_005681736.1 Inosine 5-monophosphate dehydrogenase Not tested PiCp 5 Protein 9e-135 58