Gene Information

Name : nrdE (MLBr_01734)
Accession : YP_002503825.1
Strain : Mycobacterium leprae Br4923
Genome accession: NC_011896
Putative virulence/resistance : Unknown
Product : ribonucleotide-diphosphate reductase subunit alpha
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0209
EC number : -
Position : 2094251 - 2096332 bp
Length : 2082 bp
Strand : -
Note : Catalyzes the rate-limiting step in dNTP synthesis

DNA sequence :
ATGTTGAATCTGTACGATGCGGACGGCAAGATCCAATTCGACAAGGACGTACTCGCGGCCCGCCAATTCTTCCTGCAGCA
TGTCAATCAGAACACGGTCTTTTTCCATAACCAGGACGAGAAGCTGGACTATCTGATCCGCGAGAATTACTACGAGCGTG
AGGTGCTCGATCAGTACTCGCGTAACTTTGTCAAGTCGCTGCTGGATCGTGCCTACGCCAAGAAGTTTCGGTTCTCAACG
TTTCTTGGTGCGTTCAAGTATTATACCTCTTACACGCTGAAGACGTTCGACGGGAAGCGGTATTTAGAGCGCCTCGAAGA
CCGGGTCTGCATGGTCGCACTCACGTTGGCGGCCGGTGACACCGGCTTGGCCGAGAAGCTCGTCGACGAGATCATCGACG
GCCGATTCCAGCCAGCTACCCCAACTTTTTTGAACTCGGGCAAGAAACAACGCGGCGAACCGGTGAGCTGTTTTTTGCTG
CGCATTGAGGATAACATGGAGTCGATCGGGCGATCGGTCAACTCCGCGCTACAGCTATCCAAGCGTGGCGGAGGAGTTGC
TTTGCTGCTGAGCAACATTCGTGAGCATGGTGCACCGATCAAGAACATCGAACACCAGTCTTCGGGCGTAATTCCGATCA
TGAAGTTGCTTGAAGATGCGTTCTCGTATGCCAATCAGTTGGGCGCCCGCCAAGGCGCTGGTGCGGTGTACCTGCATGCT
CATCACCCTGACATCTACCGCTTCTTGGACACTAAGCGGGAGAATGCCGACGAGAAGATCCGGATCAAGACGCTGAGCCT
GGGGGTGATAATTCCCGACATCACCTTTGAGCTGGCTAAGCGTAACGAAGACATGTACCTGTTCTCGTCGTACGACGTCG
AGCGGGTTTACGAGGTGCCGTTCGCCGATATTTCGGTGACTGAGAAGTATTATGAGATGCTCGATGACGCACGCATCCGC
AAGACCAAGATCAAGGCGCGGGAGTTTTTCCAGAAGCTGGCCGAGCTGCAGTTCGAGTCCGGTTACCCCTATGTCATGTT
CGAGGACACGGTGAACCGGGCCAACCCCATTGAAGGTAAGATCACTCACTCGAATCTATGCTCGGAGATCCTGCAGGTGT
CCACGCCGTCGTTGTTTAACGACGACTTGTCGTATGCCAAAGTGGGCAAGGACATTTCATGTAACCTGGGATCGCTGAAC
ATTGCCAAGACGATGGACTCACCGGATTTCGCGCAGACGGTTGAGGTGGCGATTCGCGCGTTGACTGCGGTGAGCGACCA
GACGCACATCAAGTCGGTGCCCTCGATCGAGCAGGGTAACAATGATTCCCACGCGATCGGGCTGGGGCAGATGAACCTGC
ATGGCTACTTGTCCCGTGAAGGAATCTTCTACGGTTCCGAAGAGGGAGTCGATTTCACCAACATTTACTTCTATACGGTG
TTGTTTCACGTGTTGCTGGCTTCGAACTCTATCGCGATCGAACGAGGTACCTTCTTCAAAGGTTTCGAGCGGTCCAAGTA
CGCGTCGGGAGAGTTCTTCGACAAATACATCGAGCAGACGTGGGAGCCGAAGACCGATAAAGTGCGTCAGTTATTCGCTG
AGGCAGCGATCCGTATTCCGACCCAAAACGACTGGAAGCGGCTGAAGGAGTTGGTGGTCGCACACGGCATCTACAACCAG
AACCTGCAGGCGGTGCCGCCGACCGGATCGATCTCCTATATCAACCATTCGACGTCGTCGATCCACCCGATCGTGTCGAA
AGTTGAGATCCGTAAGGAAGGAAAAATTGGCCGAGTTTACTATCCGGCGCCCTATATGACCAATGACAATCTGCAGTACT
ACCAGGACGCTTATGAGATCGGGTACCAGAAGATCATCGACACATACGCGGCGGCCACCCAGCACGTCGACCAAGGGCTC
TCACTGACGTTGTTCTTCAAAGACACCGCCACCACCCGGGACGTGAACAAGGCGCAGATTTATGCGTGGCGCAAGGGAAT
CAAGACGCTGTATTACATTCGGCTGCGGCAGATGGCGCTGGAAGGCACCGAAGTCGAGGGCTGCGTGTCTTGCACGCTGT
AA

Protein sequence :
MLNLYDADGKIQFDKDVLAARQFFLQHVNQNTVFFHNQDEKLDYLIRENYYEREVLDQYSRNFVKSLLDRAYAKKFRFST
FLGAFKYYTSYTLKTFDGKRYLERLEDRVCMVALTLAAGDTGLAEKLVDEIIDGRFQPATPTFLNSGKKQRGEPVSCFLL
RIEDNMESIGRSVNSALQLSKRGGGVALLLSNIREHGAPIKNIEHQSSGVIPIMKLLEDAFSYANQLGARQGAGAVYLHA
HHPDIYRFLDTKRENADEKIRIKTLSLGVIIPDITFELAKRNEDMYLFSSYDVERVYEVPFADISVTEKYYEMLDDARIR
KTKIKAREFFQKLAELQFESGYPYVMFEDTVNRANPIEGKITHSNLCSEILQVSTPSLFNDDLSYAKVGKDISCNLGSLN
IAKTMDSPDFAQTVEVAIRALTAVSDQTHIKSVPSIEQGNNDSHAIGLGQMNLHGYLSREGIFYGSEEGVDFTNIYFYTV
LFHVLLASNSIAIERGTFFKGFERSKYASGEFFDKYIEQTWEPKTDKVRQLFAEAAIRIPTQNDWKRLKELVVAHGIYNQ
NLQAVPPTGSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMTNDNLQYYQDAYEIGYQKIIDTYAAATQHVDQGL
SLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQMALEGTEVEGCVSCTL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cur_1481 YP_001800875.1 ribonucleotide-diphosphate reductase subunit alpha Not tested Not named Protein 0.0 78