Gene Information

Name : guaA (Mnod_1294)
Accession : YP_002496598.1
Strain : Methylobacterium nodulans ORS 2060
Genome accession: NC_011894
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 1368651 - 1370207 bp
Length : 1557 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACCGCCGAGCACGACAAGATCCTGATCATCGATTTCGGGAGCCAGGTGACCCAGCTCATCGCCCGCCGGGTGCGGGA
GGAGGGGGTCTATTCCGAGATCGTGCCCTATCAGGCGGCGGAAGCCGCTTTCGCAGCGCTCAAGCCGAAGGCCGTGATCC
TGTCGGGCGGGCCTGAATCGGTGACGATCGAGACCTCGCCCCGCGCGCCGCAAGGCGTGTTTGAGGCGGGCGTGCCGGTG
CTCGGCATCTGCTACGGCGAGCAGACCATGGCGGCCCAGCTCGGCGGCGAGGTCGAGGGCGGCCACCATGCCGAGTTCGG
CCGGGCCGAGATCGAGGTCATCGCCGATTCGGCCCTGTTCAAGGGCATCTGGCACGTCGGGGAGAAATACCCGGTCTGGA
TGAGCCACGGCGACCGGGTGACGAAGCTGCCGGAGGGCTTCTCCACCATCGCGATCTCGCCCAACGCCCCCTTCGCGGCG
GTGGCCGACGAGGCGCGCCGCTTCTATGCGGTGCAGTTCCATCCCGAGGTCGCCCACACGCCCCACGGGGCGCTGCTCCT
GCGCAACTTCGTGCGCGACATCGCCGGCTGCTCGGGCGACTGGTCGATGCGCGCCTTCCGGGAGGAGGCGATCGAGCGCA
TCCGCGCGCAGGTCGGGACCGGGAAGGTGCTGTGCGGCCTCTCGGGCGGCGTCGACTCGGCGGTGGCGGCGGTGCTGATC
CACGAGGCGATCGGCGAGCAGCTCACCTGCGTGTTCGTGGATCACGGCCTGCTGCGCCTCGGCGAGGCCGAGGAGGTGGT
GCGGCTGTTCCGCGACCACTACAACATCCCCCTCGTCCACGTGCAGGCGCAGGATCTCTTCCTCGGCGCGCTCGCCGGCG
TCACCGACCCGGAGGTGAAGCGCAAGACGATCGGGCGCCTGTTCATCGACGTGTTCGAGGCCGAGGCGAAGAAGATCGGC
GGCGCGGCGTTCCTGGCGCAGGGCACCCTCTACCCGGATGTGATCGAGAGCGTGTCCTTCACGGGCGGCCCCTCGGTGAC
GATCAAGAGCCACCACAATGTCGGCGGGCTGCCCGAGCGCATGAACATGAAGCTCGTGGAGCCCCTGCGCGAGCTGTTCA
AGGACGAGGTGCGGGTGCTCGGCCGCGAGCTCGGCCTGCCCGACGCCTTCGTGGGCCGGCATCCCTTCCCGGGGCCGGGC
CTCGCCATCCGCTGCCCGGGCGAGATCACGGCCGAGAAGCTCGATGCGCTCCGCAAGGCCGACGCGATCTACCTGGAGGA
GATCCGCAAGGCCGATCTCTACGACGCGATCTGGCAGGCCTTCGCGGTGATCCTGCCGGTGAAGACGGTGGGCGTGATGG
GCGACGGGCGCACCTACGACCATGTCTGCGCGCTGCGCGCCGTCACCTCGGTCGACGGCATGACGGCGGACTTCTATCCT
TTCGACATGACGTTCCTGGGCCGCGTCGCCACCCGGATCATCAACGAGGTCAAGGGCATCAACCGGGTCACCTACGACAT
CACCTCGAAGCCTCCGGGCACGATCGAGTGGGAGTGA

Protein sequence :
MTAEHDKILIIDFGSQVTQLIARRVREEGVYSEIVPYQAAEAAFAALKPKAVILSGGPESVTIETSPRAPQGVFEAGVPV
LGICYGEQTMAAQLGGEVEGGHHAEFGRAEIEVIADSALFKGIWHVGEKYPVWMSHGDRVTKLPEGFSTIAISPNAPFAA
VADEARRFYAVQFHPEVAHTPHGALLLRNFVRDIAGCSGDWSMRAFREEAIERIRAQVGTGKVLCGLSGGVDSAVAAVLI
HEAIGEQLTCVFVDHGLLRLGEAEEVVRLFRDHYNIPLVHVQAQDLFLGALAGVTDPEVKRKTIGRLFIDVFEAEAKKIG
GAAFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRVLGRELGLPDAFVGRHPFPGPG
LAIRCPGEITAEKLDALRKADAIYLEEIRKADLYDAIWQAFAVILPVKTVGVMGDGRTYDHVCALRAVTSVDGMTADFYP
FDMTFLGRVATRIINEVKGINRVTYDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 6e-129 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 6e-129 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 5e-129 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 8e-115 52