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Name : ureC (Cyan7425_2269) Accession : YP_002482990.1 Strain : Cyanothece sp. PCC 7425 Genome accession: NC_011884 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : - Position : 2188961 - 2190670 bp Length : 1710 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGAGCTATCCCATGAATCGCCGCGCCTATGCGGAAACCTATGGGCCCACCGTGGGCGATCGCGTCCGGCTGGCGGATAC CAATCTGATCATCGAAGTGGAGCGGGACTATACCACCTATGGGGATGAAGTCAAGTTTGGCGGCGGTAAGGTGATCCGGG ATGGCATGGGACAGTCACCCATTACAAACAAAGATGGGGCGGTGGATCTGGTGATTACCAATGCCCTGATCCTGGACTGG TGGGGAATTGTCAAAGCTGATGTCGGGATTAAGGAGGGGCGAATTGAACGGATTGGTAAAGCGGGCAATCCTTATATCCA GGACAATGTAGATATTATTATTGGCCCCGGTACGGAAGTGCTGGCGGGGGAGGGGATGATCCTGACCGCGGGGGGCATCG ATACCCATATTCATTTCATCTGTCCCCAGCAGATTGAAACCGCGATCGCCTCTGGGATTACCACCATGATTGGGGGGGGG ACTGGCCCAGCAACGGGAACCAATGCCACAACCTGCACCCCTGGCCCCTGGAATCTCTACCGAATGCTGCAGGCGGCAGA TGCGTTTCCAATGAATTTAGGCTTTCTGGGTAAAGGCAATGCCAGTCAACCGGAGGCTTTAGTCGAGCAGGTCGTAGCTG GTGCAATGGGGTTGAAGCTGCATGAAGATTGGGGTACAACCCCCGCCGCGATCGATACCTGTTTGAGTGTGGCAGACGAT TATGACATCCAGGTGGCGATTCACACCGATACCCTGAACGAAGCGGGCTATGTCGAGAACACGATCGCCGCTTTCAAAAA TAGAGTCATTCACACCTATCACACCGAGGGAGCGGGAGGTGGCCATGCCCCGGACATTATTAAAGTCTGTGGTCAACCGA ATGTTTTGCCCTCCTCCACCAATCCCACCCGGCCCTACACCTTAAATACCCTGGATGAACACCTGGATATGCTGATGGTC TGTCATCATCTTTCTCCCAGCATTCCAGAGGATGTCGCTTTTGCCGAATCCCGCATTCGCCGCGAGACGATCGCCGCCGA GGATATTCTGCACGATCTCGGTGCCTTTAGCATGATTTCCTCCGATTCCCAGGCCATGGGTCGGGTGGGAGAAGTGATCC TGCGCTGCTGGCAAACCGCTCACAAGATGAAAGAGCAACGCGGTCCACTGCCGGAGGATTCCGATCGTCAGGATAACTAC CGGGCTAAACGCTACATTGCCAAATACACGATTAATCCGGCCATCACCCACGGCATTGCTGAGTATGTCGGCTCGGTTGA ACCTGGTAAGCTGGCAGATCTTTGTCTCTGGCGACCGGCCCTGTTTGGGGTCAAACCCGAAATTGTGCTCAAAGGTGGAA TGATTGCCTGGTCCCAGATGGGAGATGCCAATGCCAGTATTCCCACCCCCCAGCCCATCCATATGCGCCCGATGTTTGGC AGTTACGGGGGAGCGATCGCCGCGACTTCCCTCACCTTCCTCTCCAAAGCGGCGTTGAAAAAAGATATTGCCAAAAAACT CAACCTACAGAAACCTGCCGTCGCCGTGGGGGGCATTCGTAACCTGAGTAAACGCGACATGAAGCTCAACGATGCCCTAC CCCAGATGGAAGTCGATCCAGAAACCTATCAAGTCAGGGCCGATGGGCAACTGCTCACCTGTGAACCAGCAACGATCTTA CCCATGGCGCAACGATATTTCTTGTTCTAA Protein sequence : MSYPMNRRAYAETYGPTVGDRVRLADTNLIIEVERDYTTYGDEVKFGGGKVIRDGMGQSPITNKDGAVDLVITNALILDW WGIVKADVGIKEGRIERIGKAGNPYIQDNVDIIIGPGTEVLAGEGMILTAGGIDTHIHFICPQQIETAIASGITTMIGGG TGPATGTNATTCTPGPWNLYRMLQAADAFPMNLGFLGKGNASQPEALVEQVVAGAMGLKLHEDWGTTPAAIDTCLSVADD YDIQVAIHTDTLNEAGYVENTIAAFKNRVIHTYHTEGAGGGHAPDIIKVCGQPNVLPSSTNPTRPYTLNTLDEHLDMLMV CHHLSPSIPEDVAFAESRIRRETIAAEDILHDLGAFSMISSDSQAMGRVGEVILRCWQTAHKMKEQRGPLPEDSDRQDNY RAKRYIAKYTINPAITHGIAEYVGSVEPGKLADLCLWRPALFGVKPEIVLKGGMIAWSQMGDANASIPTPQPIHMRPMFG SYGGAIAATSLTFLSKAALKKDIAKKLNLQKPAVAVGGIRNLSKRDMKLNDALPQMEVDPETYQVRADGQLLTCEPATIL PMAQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 2e-170 | 69 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 2e-170 | 69 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 5e-166 | 65 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-167 | 65 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 2e-167 | 65 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-167 | 65 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_002482990.1 | urease subunit alpha | VFG0270 | Protein | 8e-152 | 63 |
