Gene Information

Name : topB (HAPS_0428)
Accession : YP_002475047.1
Strain : Haemophilus parasuis SH0165
Genome accession: NC_011852
Putative virulence/resistance : Unknown
Product : DNA topoisomerase III
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0550
EC number : -
Position : 461455 - 463377 bp
Length : 1923 bp
Strand : -
Note : decatenates replicating daughter chromosomes

DNA sequence :
ATGCGTTTATTCATTGCAGAAAAGCCAAGTTTAGGGCGTGCGATTGCTGATGTATTGCCGAAACCCCATACCCGTGGGGA
CGGCTTTATTCAGTGTGGCGAAGACAATGTGGTCACTTGGTGTATCGGTCACTTGTTAGAACAAGCTGAACCTGATGCTT
ATGATGAACGTTTCAAAATGTGGCGAATGGAACATTTGCCGATTATCCCTGAACAGTGGAAGCTGATCCCCAAAAAAGAG
ACACTCAAGCAGTTTAAGGTGGTAGAGCGTTTAATTAAACAAGCGGATATTTTAGTCAATGCAGGCGACCCAGATCGTGA
AGGACAACTGTTGGTGGACGAAGTTTTTGGCTACTTAAATTTATCCCCTGAGCGGAAATCCCAAATTCAGCGGTGTTTGA
TTAGCGATCTCAACCCTAATGCTGTCAAAAAAGCGATTGAAAAATTGCAATTTAATCGAGATTTCGTACCGCTTGCTACA
TCGGCTTTAGCTCGTGCAAGGGCAGACTGGCTATATGGGATCAATATGACCAGAGCCTATACCCTACAAGGGCGTTGGGC
AGGTTATAAAGGCGTGCTTTCCGTTGGGCGTGTACAAACGCCAGTGTTGGGCTTGATTGTCCGACGTGATCTTGAGATCG
AAAATTTTATCCCAAAAGATTATTTTGAAGTGTTGGCAAATGTGGTTGTTCCTGAAACCCAAGAACGTTTTCAAGCACAA
TGGCAACCCAGTAAAGCCTGCGAAGATTATCAAGATGAAGATGGACGAGTGCTTTCTCGCCCACTTGCTGAGAATGTAGT
AAAACGTATCACGGATCAAGCCGCTTGCGTTACCGAATATCAAGATAAAATGGAAAGTGAAGCAGCACCACTCCCTTATT
CACTCTCAGCCTTGCAAATTGATGCGGCTCGCCGTTTTGGCTTATCTGCACAAGATGTGCTTGATGTTTGCCAACGGCTG
TATGAAACCCATAAATTGATTACTTATCCCCGTTCCGATAACCGTTATTTGCCGAATGAACATTTTGCCGATCGCCTAAA
AGTGATGGCGGCAATTGCGCATCATCTGCCTGAGTATGCTCAAAAGCCTGATGCAGTTGATCCGAATAAGAAAAACCGTT
GTTGGAATGACAGTAAGGTAGAAGCTCACCACGCCATTATCCCGACGGCACGTCAAGGGCGGCAAGTTCACTTAACTCAG
AATGAACAGTGGATTTATCAGCTTATTGCTCGACAATATTTAATGCAATTTTGCCCTGATGCAGAATATCGTAAAGGAAA
AATTGTGTTAAATATCGCAGGGGGGACTTTTATTGCGCAAGCTAGAAACTTGGTTGTCGCAGGTTGGAAGTCTTTGTTAG
GCAAAGAAGATAATGATGAAATCGTTGAACCTTTGCTACCTGTGGTTAAAAAAGATCAGCAGTTATGGTGTGAAAGCGGT
GAGATCATCAGTAAAAAAACACAGCCTCCACGCCATTTTACTGATGCGACCTTGTTGTCAGCAATGACGGGTATTGCTCG
CTTTGTACAAGATAAACAGCTCAAAAAAGTGTTGAGAGAAACCGATGGCTTGGGTACAGAAGCCACCCGAGCTGGCATTA
TTGAATTATTATTCAAACGTGGTTTTTTAATCAAAAAAGGCAGAAATATTCATAGTACAGAAGCAGGGCGAACCTTAATT
AGTGCCTTGCCAGATGTTGCAACACAGCCTGATATGACAGCTCACTGGGAAATGCAACTAACAGACATCAGCAAAAAACA
AGCCAGTTATCAACAATTTATGGCAGATTTAAACCAGCGTTTGCCAAGTTTATTAAGCTCTCCAAACAAGCAGATTTTGC
AAAGTTTGGCGAAAATAACACCGCTTACAACAAGTTCTAAATCACGTTATACCCGTAAATCTACGCAAAATGTTGAAAAA
TAA

Protein sequence :
MRLFIAEKPSLGRAIADVLPKPHTRGDGFIQCGEDNVVTWCIGHLLEQAEPDAYDERFKMWRMEHLPIIPEQWKLIPKKE
TLKQFKVVERLIKQADILVNAGDPDREGQLLVDEVFGYLNLSPERKSQIQRCLISDLNPNAVKKAIEKLQFNRDFVPLAT
SALARARADWLYGINMTRAYTLQGRWAGYKGVLSVGRVQTPVLGLIVRRDLEIENFIPKDYFEVLANVVVPETQERFQAQ
WQPSKACEDYQDEDGRVLSRPLAENVVKRITDQAACVTEYQDKMESEAAPLPYSLSALQIDAARRFGLSAQDVLDVCQRL
YETHKLITYPRSDNRYLPNEHFADRLKVMAAIAHHLPEYAQKPDAVDPNKKNRCWNDSKVEAHHAIIPTARQGRQVHLTQ
NEQWIYQLIARQYLMQFCPDAEYRKGKIVLNIAGGTFIAQARNLVVAGWKSLLGKEDNDEIVEPLLPVVKKDQQLWCESG
EIISKKTQPPRHFTDATLLSAMTGIARFVQDKQLKKVLRETDGLGTEATRAGIIELLFKRGFLIKKGRNIHSTEAGRTLI
SALPDVATQPDMTAHWEMQLTDISKKQASYQQFMADLNQRLPSLLSSPNKQILQSLAKITPLTTSSKSRYTRKSTQNVEK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
topB NP_458624.1 topoisomerase B Not tested SPI-7 Protein 2e-108 42
topB NP_807836.1 DNA topoisomerase III Not tested SPI-7 Protein 2e-108 42
topB AAF14809.1 topoisomerase B Not tested SPI-7 Protein 2e-108 42
topB1 YP_005176228.1 DNA topoisomerase III Not tested ICEPmu1 Protein 2e-108 41
pph56 CAI36097.1 Topoisomerase IA Not tested PPHGI-1 Protein 5e-105 41