Gene Information

Name : metB (HAPS_2273)
Accession : YP_002476650.1
Strain : Haemophilus parasuis SH0165
Genome accession: NC_011852
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : -
Position : 2238939 - 2240045 bp
Length : 1107 bp
Strand : -
Note : catalyzes the formation of cysteine from cystathionine; in B. subtilis also has O-acetylhomoserine thiolyase activity

DNA sequence :
ATGAAATATAACAACATTGAAAGTACTTTAGTCCAACTGGGTAATCGTACTGATGAGCGTACTGGTGCGGTGGCGACCCC
GATTTTCCTTTCGACTGCCTATGGACATATGGGGATCGGCGAGTCCACAGGCTTTGACTATACTCGTACCAAAAACCCAA
CTCGTAGTGTACTTGAGCAAGGCATTGCGGACTTAGAGGGTGGCGATGCAGGTTTTGCATTAGCGTCAGGTATGGCGGCA
ATTCAATTAATTATGTCGCTCTTTACTGCCCCTGACGAGTGGATTATCTCTAGCGATGTTTATGGCGGAACTTACCGCTT
GTTAGATTTTAGCTACAAAAATAACAATACCGTGAAGCCTGTTTATGTGAACACGGCAGATCTAGACGCGATTGAGAAAG
CGATTAACCCAAATACCAAAGCGATTTTTGTTGAAACACCGTCTAATCCGTTGATGGAAGAGTGTGATGTTGCAGCGATT
GCGAAAATTGCTAAAAAGCATAATTTACTGCTGATTGTCGATAATACTTTCTTAACACCAGTATTATTCCGCCCGATTGA
ACTTGGGGCAGACATTGTTATTCACAGTGCAACCAAATATTTGGCAGGACATAATGATGTGTTAGCAGGTTTGGTGGTAG
CAAAAGGGCAAGCGTTATGTGACCGCTTGTTCTATTTGCAAAATGGTGCTGGGGCGGTGCTTTCACCGTTTGACGCTTAT
ATGATTATTCGTGGCTTAAAAACCCTTGCGTTGCGTGTTGAGCATCACCAACAAAATGCCACTGAACTCGCTAAATTCTT
ATCGGAACAACCGCAAGTGCAAGATGTGCTTTATTCTGGTAAAAGCGGTATGTTATCTTTCCGCTTGAAAGATGAAAACT
GGGTTAATCCATTCTTAAAAGCGATCAAGATGATTACCTTTGCGGAAAGTTTAGGCGGTACAGAAAGTTTTATTACTTAC
CCTGCAACCCAAACCCATATGGATATTCCTGAAGCAGAACGTATCGCTCGTGGTGTATGTAATAAGCTCTTGCGTTTTTC
GGTGGGGCTTGAACACGTTGAGGATATTAAAGCAGACTTGCTACAAGCATTTGCTCAGTTGAAGTAA

Protein sequence :
MKYNNIESTLVQLGNRTDERTGAVATPIFLSTAYGHMGIGESTGFDYTRTKNPTRSVLEQGIADLEGGDAGFALASGMAA
IQLIMSLFTAPDEWIISSDVYGGTYRLLDFSYKNNNTVKPVYVNTADLDAIEKAINPNTKAIFVETPSNPLMEECDVAAI
AKIAKKHNLLLIVDNTFLTPVLFRPIELGADIVIHSATKYLAGHNDVLAGLVVAKGQALCDRLFYLQNGAGAVLSPFDAY
MIIRGLKTLALRVEHHQQNATELAKFLSEQPQVQDVLYSGKSGMLSFRLKDENWVNPFLKAIKMITFAESLGGTESFITY
PATQTHMDIPEAERIARGVCNKLLRFSVGLEHVEDIKADLLQAFAQLK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-68 44
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 3e-69 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metB YP_002476650.1 cystathionine gamma-synthase BAC0207 Protein 2e-53 41