Gene Information

Name : guaA (CKR_0411)
Accession : YP_002470876.1
Strain : Clostridium kluyveri NBRC 12016
Genome accession: NC_011837
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 446921 - 448453 bp
Length : 1533 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGAAAGAGAATTAGTTATTGTAGTTGATTTTGGAGGGCAATATAATCAACTTATAGCAAGAAGAGTGAGAGAAAATAA
TGTATACTGTGAAATAGTCCCTTATACCTATTCTGTAGATAAAATAAAAGAAAAAAACCCCAGAGGAATAATATTTACAG
GAGGACCTAATAGTGTATATGATGATAATGCTCCTAAAATAAGTGAAGATATATTTGAAATAGGTGTACCGGTTTTAGGT
ATATGTTATGGTCATCAACTTATATGTACTACACTAGGGGGGAAAGTTGAAAGTGCACAAGTAAGGGAATATGGAAAAAC
AGATGTGGTTCTCAATAATAGCAGTGGTTTATTTTCTGGTATAGATAAAAATGAGAGTTGTTGGATGAGTCATACGGATT
TTGTATCATATCCTCCAGAAGGATTTAAAATAATAGGAAAATCAGGAGAAAGCCCTGTAGCTGCTGTAGAGAATATTGAT
AAAAAAATATATGGAGTTCAGTTTCATCCAGAAGTTGAACATACCCCTTTTGGTAAAAAGATGCTTTCTAATTTTTTATT
TGATATATGTAATTTAAAAGGAGATTGGTCTATGTCTTCTTTTGTGGATGAAAAGATAAAATCAATAAAAGAAGAAGTTG
GAGATAAAAAGGTAATATGTGCCATGTCCGGTGGAGTAGATTCTTCAGTGGCAGCAATGATTGTACATAAGGCTGTAGGA
AAGCAGCTTACCTGTATATTTGTAGATCATGGTCTTTTAAGAAAAGATGAAGGAGATCAGGTTGAAGATATATTTAAAAA
ACAGTTTAATATGAATTTTATAAGAGTAAATGCAGAGAAAAGATTCTTACAAAAGTTAAAAGATATATCCGATCCTGAAA
AGAAGAGAAAAATAATAGGAGAAGAATTTATAAGAGTATTTGAAGAAGAGGCTAAAAAGTTAGGAGAAATAGCTTTTCTG
GTCCAAGGAACCATATATCCTGATGTGGTAGAAAGTGGGCTTGGAACATCTGCTACTATAAAAAGTCATCATAATGTAGG
CGGATTACCTGAAGATATGGATTTTAAACTTATAGAGCCTCTAAGGGAACTATTTAAAGATGAGGTTAGGGCAGTAGGTG
AAGAACTTGGTATACCTCATAAATTGGTGTGGAGACAACCATTTCCGGGACCGGGACTTGCTATAAGAGTTTTAGGAAAT
ATTACAGAGGAAAAGCTTCAAATAACTAGAGATGCAGATGCAATATTTAGAGAAGAAATAGCAAAGGCTAATTTAGATGA
AACTATATGGCAGTATTTTGCCTGTCTTCCCAACATACGCTCTGTAGGAGTAATGGGGGATGAGAGAACTTATTGCTATA
CTATTGCATTAAGGGCTGTTATATCCACAGATGCCATGACTTCTGACTGGGCTAGAATACCTTATGAAGTTTTAGATAAA
GTTTCAAGAAGAATTGTTAATGAAGTTAAAGGAGTAAACAGGATTGTTTATGATATAACCTCAAAACCTCCTGCTACAAT
TGAGTGGGAATAA

Protein sequence :
MERELVIVVDFGGQYNQLIARRVRENNVYCEIVPYTYSVDKIKEKNPRGIIFTGGPNSVYDDNAPKISEDIFEIGVPVLG
ICYGHQLICTTLGGKVESAQVREYGKTDVVLNNSSGLFSGIDKNESCWMSHTDFVSYPPEGFKIIGKSGESPVAAVENID
KKIYGVQFHPEVEHTPFGKKMLSNFLFDICNLKGDWSMSSFVDEKIKSIKEEVGDKKVICAMSGGVDSSVAAMIVHKAVG
KQLTCIFVDHGLLRKDEGDQVEDIFKKQFNMNFIRVNAEKRFLQKLKDISDPEKKRKIIGEEFIRVFEEEAKKLGEIAFL
VQGTIYPDVVESGLGTSATIKSHHNVGGLPEDMDFKLIEPLRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGN
ITEEKLQITRDADAIFREEIAKANLDETIWQYFACLPNIRSVGVMGDERTYCYTIALRAVISTDAMTSDWARIPYEVLDK
VSRRIVNEVKGVNRIVYDITSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-158 61
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-158 61
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 9e-159 61
guaA NP_938969.1 GMP synthase Not tested Not named Protein 5e-138 53