Gene Information

Name : thyA (BLA_0434)
Accession : YP_002469311.1
Strain : Bifidobacterium animalis AD011
Genome accession: NC_011835
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 544314 - 545114 bp
Length : 801 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGCCGTATGAGGACCTGCTGCGCAAGATTCTCATGGAAGGCAATCTCAAGAACGACCGCACCGGCACAGGCACGATCTC
GCTGTTCGGCCAGCAGATGCGTTTCGATCTGGCGAAGGGGTTCCCGCTGCTCACCACGAAGCGCGTGTTCTTCAAGGGCA
TCGCCTATGAACTGCTGTGGTTCTTGAAGGGCTCGAGCAATGTGCACTGGCTGCAGGAGCACAATGTGCACATCTGGGAC
GAGTGGGCCGACGAGAACGGTGATCTTGGTCCGGTGTACGGTGTGCAGTGGCGCAGTTGGCCTGCTCCCACCGCAGACGA
TCCCGACCGCACAATCGACCAGATCTCCAATGTGCTTGAGCTCATCAAACACAACCCGGATTCGCGGCGCATGGTGGTCA
CCGCGTGGAACCCGGCCGAGGTGGAGAACATGGCGTTGCCGCCGTGCCACGCGCTGTTCCAGTTCTATGTGGCCGATGGC
AGACTCAGCTGCCAGCTGTACCAGCGTTCGTGTGACATGTTCCTCGGCGTGCCGTTCAACATCGCCAGCTATTCGCTGCT
CACGATGATGATGGCACAGCAGGCCGGCTTGGAACCCGGTGAATTCGTGTGGACCGGCGGCGACTGCCACATCTACGACA
ATCACGTGGAGCAGGTGCTTGAGCAGCTCTCGCGCGAACCCTACCCATACCCGAGGATGGAGATTCGCAAGGCCGATTCT
CTGTTCGACTACCAGTATTCCAATTTCCATATCGCGGACTATCGATACCACCCCACCATCAAGGCTCCGATCGCGGTGTG
A

Protein sequence :
MPYEDLLRKILMEGNLKNDRTGTGTISLFGQQMRFDLAKGFPLLTTKRVFFKGIAYELLWFLKGSSNVHWLQEHNVHIWD
EWADENGDLGPVYGVQWRSWPAPTADDPDRTIDQISNVLELIKHNPDSRRMVVTAWNPAEVENMALPPCHALFQFYVADG
RLSCQLYQRSCDMFLGVPFNIASYSLLTMMMAQQAGLEPGEFVWTGGDCHIYDNHVEQVLEQLSREPYPYPRMEIRKADS
LFDYQYSNFHIADYRYHPTIKAPIAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 2e-89 70
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 7e-58 44