Gene Information

Name : guaA (BLA_1482)
Accession : YP_002470340.1
Strain : Bifidobacterium animalis AD011
Genome accession: NC_011835
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1831660 - 1833222 bp
Length : 1563 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGCAGCAGGTCCTGTCCTTGTCGTTGATTTCGGAGCGCAGTACGCGCAGCTCATCGCGCGCCGCGTGCGCGAGGCGAA
CGTGTATTCCGAATTGGTGCCTCATTCGATGCCGGTCGAGGAGATGCTGGCCAAGAAGCCGTCCGCGATCATACTGTCAG
GCGGCCCGGCGTCGGTGTACGAACCCGGTGCTCCCACCATTGACAAGAGCATCTTCACGGCCGGAGTGCCGGTGCTTGGC
ATCTGCTATGGCTTCCAGGTGATGGCCCATGAGCTCGGCGGCGACGTCGACAAGGCGGCGCTCGGCGAGTACGGCAAGAC
GGAGGCGGTGGTGGACGATGCCACGGGCATTCTCGACAGTTCGCCATCCCTGCAGACCACTTGGATGAGCCATGGTGTCG
CCGTGAACAAGGCACCCGCCGGATTCGAAGTCACCGCGCATACCGAAGGGGCGCCGGTGGCTGCGATGGAGGATCCCTCA
CGCAAACTCTACGGCGTGCAGTGGCATCCTGAGGTCAAGCACACGCCGTTGGGACAGGATCTGATCGAGAATTTCCTGCA
TGATTGCGCCGGCATCGAAGCCGATTGGAACGCAAGGAACATCATCGACGAGCAGGTCGCTGCGATTCGTGAGAAGGTCG
GTGACGCACGGGTCATCTGTGGTCTGTCTGGTGGAGTCGATTCGGCCGTGGCTGCAGCGCTCGTGCACCGCGCGATCGGT
GACCAGCTCACCTGCGTGTTCGTGGATCACGGTCTGCTACGCAAGGGCGAGGCCGAGCAGGTCAAACATGATTTCGTCGC
GGCGACCGGCATCAAGCTCATCGCCGTCGATGCCTCCAAGGATTTCCTCGATGCACTCAAGGGCGTCTCCGATCCTGAGA
CGAAGCGCAAGATCATCGGCGAAAAATTCATCCGCACTTTCGAGAAGGCGCAGCGCCAGGTGATAGAGGAGGCCGGTGCC
CAGGGCAAGGAGGTCAAGTTCCTCGTGCAGGGCACGCTTTACCCGGACGTCGTCGAATCCGGTGGCGGCGACGGCGCCTC
GAACATCAAGTCGCATCATAACGTCGGTGGTTTGCCTGACGACATCAAGTTCGAACTGATTGAGCCGCTCCGTTCGCTGT
TCAAAGACGAGGTGCGCGCCATCGGCACCGAACTCGGCTTGCCGGACGAGATTGTCTGGCGTCAACCGTTCCCCGGGCCG
GGTCTGGGCATCCGCATCATCGGTGAGATCACGAAGGAACGTCTCGACTTGCTGCGTGATGCCGATGCGATTGCCCGCGA
GGAGCTCTCGAAGGCCGGTCTCGACCGCGACATCTGGCAGTGCCCGGTCGTGCTGCTCGCCGACGTGCACTCCGTCGGCG
TGCAGGGCGACGAACGCACCTACGGTTCGCCGATCGTGCTGCGGCCGGTCAGCTCTGAGGACGCGATGACTGCCGACTGG
TCGCGTGTGCCGTACGACGTGCTCGCCACCATCTCGACTCGCATCACGAACGAATGCCGTCAGATCAACCGCGTTGTGCT
CGACTGCACGTCGAAGCCACCGGCGACAATCGAGTGGGAATAA

Protein sequence :
MAAGPVLVVDFGAQYAQLIARRVREANVYSELVPHSMPVEEMLAKKPSAIILSGGPASVYEPGAPTIDKSIFTAGVPVLG
ICYGFQVMAHELGGDVDKAALGEYGKTEAVVDDATGILDSSPSLQTTWMSHGVAVNKAPAGFEVTAHTEGAPVAAMEDPS
RKLYGVQWHPEVKHTPLGQDLIENFLHDCAGIEADWNARNIIDEQVAAIREKVGDARVICGLSGGVDSAVAAALVHRAIG
DQLTCVFVDHGLLRKGEAEQVKHDFVAATGIKLIAVDASKDFLDALKGVSDPETKRKIIGEKFIRTFEKAQRQVIEEAGA
QGKEVKFLVQGTLYPDVVESGGGDGASNIKSHHNVGGLPDDIKFELIEPLRSLFKDEVRAIGTELGLPDEIVWRQPFPGP
GLGIRIIGEITKERLDLLRDADAIAREELSKAGLDRDIWQCPVVLLADVHSVGVQGDERTYGSPIVLRPVSSEDAMTADW
SRVPYDVLATISTRITNECRQINRVVLDCTSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-174 69
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-139 53
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-139 53
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-139 53