Gene Information

Name : merA (BCAH820_4533)
Accession : YP_002453482.1
Strain : Bacillus cereus AH820
Genome accession: NC_011773
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : -
Position : 4290613 - 4292253 bp
Length : 1641 bp
Strand : -
Note : identified by match to protein family HMM PF00070; match to protein family HMM PF00403; match to protein family HMM PF01266; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR02053

DNA sequence :
ATGAAAAAGTATCGAGTAAACGTTCAAGGGATGACTTGCACGGGTTGTGAAGAGCATGTTGCTGTTGCTCTTGAAAACAT
GGGTGCAAAAGAGATTGAAGTGGATTTTCGTCGCGAAGAAGCCGTATTTGAGCTTCCGAATGACGTGGAGGTGGAAAGAG
CGAAAAAGGCGATTTCTGAAGCCAAATACCAGCCAGGAGAAACAGAAGAAGTAAACCAGCAAGAAACGGTGCAACTTGGA
GATGAAGGCGATTATGACTACATTATCATTGGTTCTGGTGGAGCATCCTTTTCATCTGCCATTGAAGCCGCGAAATACGG
AGCGAACGTGGCAATCATCGAACGTGGCACAGTGGGTGGAACATGCGTGAACATCGGATGTGTTCCTTCAAAGACGCTGT
TAAGAGCTGGAGAAATCAATCACATAGCAAAAAACAATCCGTTTGTGGGATTGCACACGTCAGCAGGCAATGTCGATTTG
GCTCCATTGATTAAGCAGAAAAACGATTTGGTGACGGATCTTCGAAACTCGAAATATGTTGATTTAATTGATGACTACGG
CTTTGAATTAATAAAAGGTGAAGCGAAATTCGTGGATGAAAAAACCGTCGAAGTGAATGGCAAGCAGTTATCAGCCAAAC
GATTTTTAATCGCGACAGGTGCTTCACCTGCTGTACCAAAGATTCCTGGATTAGAAGAGGTAGATTTTTTAACAAGTACA
ACATTACTTGAATTAAAACAGGTTCCAAAGCGTCTTACAGTCATCGGTTCAGGATATATCGGTATGGAATTGGGACAACT
ATTCCATCATTTGGGTTCAGAAGTAACATTGATGCAAAGAAGTCCACGACTGTTAAAGGAATACGATCCTGAAGTGTCAG
AAGCGATCACGCAAGCATTAACAGAACAAGGGATTAATTTAGTAACAGGAGCATCCTTTGAACGAATCGAACAAGACGGA
GACGTTAAAAAGGTTCATGTTGAAGTCAATGGCAAGAAGCGAATCATTGAAGCAGATCAATTACTAGTTGCCACTGGAAG
AACACCAAATACGACGACTTTGGATTTAGAGGTAGCAGGTGTTGAAGTAGGCTCCCGTGGTGAAATTATAATCGATGAGT
ATTCAAAAACAACGAATTCAAGCATCTATGCAGCAGGAGATGTGACGCTTGGACCTCAATTTGTATATGTGGCAGCTTAT
CAAGGTGGAATTGCAGCAGGAAATGCCATCGGAGGACTGAATAAAAAGCTGAATTTAGAAGTGGTTCCAGGGGTTACGTT
TACAGCTCCAGCGATTGCAACCGTTGGTTTAACGGAGCAACAAGCAAAAGAAAAAGGCTATGAAGTGAAAACATCCGTCT
TGCCTTTAGATGCCGTTCCGAGAGCCTTGGTTAATCGAGAAACAACAGGTGTATATAAATTAGTGGCAGACGCAAAAACA
ATGAAGATATTAGGGGCTCATGTAGTAGCAGAAAATGCAGGAGAAGTAATTTATGCGGCGACACTGGCTATCAAATTCGG
TTTAACCGTGGAAGATCTCCGAGAAACCATGGCTCCATATTTAACAATGGCAGAAGGTATAAAATTAGCTGCCCTTACGT
TTGATAAAGATGTATCAAAATTATCTTGTTGTGCAGGTTAA

Protein sequence :
MKKYRVNVQGMTCTGCEEHVAVALENMGAKEIEVDFRREEAVFELPNDVEVERAKKAISEAKYQPGETEEVNQQETVQLG
DEGDYDYIIIGSGGASFSSAIEAAKYGANVAIIERGTVGGTCVNIGCVPSKTLLRAGEINHIAKNNPFVGLHTSAGNVDL
APLIKQKNDLVTDLRNSKYVDLIDDYGFELIKGEAKFVDEKTVEVNGKQLSAKRFLIATGASPAVPKIPGLEEVDFLTST
TLLELKQVPKRLTVIGSGYIGMELGQLFHHLGSEVTLMQRSPRLLKEYDPEVSEAITQALTEQGINLVTGASFERIEQDG
DVKKVHVEVNGKKRIIEADQLLVATGRTPNTTTLDLEVAGVEVGSRGEIIIDEYSKTTNSSIYAAGDVTLGPQFVYVAAY
QGGIAAGNAIGGLNKKLNLEVVPGVTFTAPAIATVGLTEQQAKEKGYEVKTSVLPLDAVPRALVNRETTGVYKLVADAKT
MKILGAHVVAENAGEVIYAATLAIKFGLTVEDLRETMAPYLTMAEGIKLAALTFDKDVSKLSCCAG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 2e-175 68
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 3e-175 68
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 1e-81 46
merA ABQ57371.1 MerA Not tested SGI1 Protein 3e-82 46
merA AGK07021.1 MerA Not tested SGI1 Protein 3e-82 46
merA AGK07079.1 MerA Not tested SGI1 Protein 3e-82 46
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 2e-80 46
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 1e-80 46
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 3e-81 45
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 5e-79 44
merA AFG30120.1 MerA Not tested PAGI-2 Protein 5e-79 44
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 6e-79 44

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
merA YP_002453482.1 mercuric reductase BAC0224 Protein 0.0 80
merA YP_002453482.1 mercuric reductase BAC0651 Protein 1e-175 68
merA YP_002453482.1 mercuric reductase BAC0652 Protein 3e-81 46
merA YP_002453482.1 mercuric reductase BAC0653 Protein 3e-80 46
merA YP_002453482.1 mercuric reductase BAC0650 Protein 3e-79 45
merA YP_002453482.1 mercuric reductase BAC0649 Protein 3e-78 42