Gene Information

Name : topB (AFE_1738)
Accession : YP_002426158.1
Strain : Acidithiobacillus ferrooxidans ATCC 23270
Genome accession: NC_011761
Putative virulence/resistance : Unknown
Product : DNA topoisomerase III
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0550
EC number : 5.99.1.2
Position : 1501586 - 1503685 bp
Length : 2100 bp
Strand : -
Note : identified by match to protein family HMM PF01131; match to protein family HMM PF01751; match to protein family HMM TIGR01056

DNA sequence :
ATGAAACTATACATCGCCGAGAAGCCCAGCCTGGGCAAAGGGATCGCCGAGTATTTGCCCGGATCGAAAAACAAAGGGAA
CGGCTTCATCCAGTGCGGAGTGGATACCGTCGTAACCTGGTGTTTCGGCCATATCTTCGAGCAGGAAGAGCCGGACTTCT
ATACGCCTGATGATGTTCCCACCACGCCAAAGGGCAAGAAGAAATGGCGATTTGAGGAACTGCCCATATTTCCTGAGCAA
TGGAAGAAGCGGGCGAAGGATGACGCCAAGGCCCAGATCAAGGTGATCCGGGCCTTGCTCAAGAAAGCCTCGTCTGTCGT
CAATGCAGGCGACCCGGACCGAGAGGGCCAGCTGCTGGTGGATGAGGTCCTGGAGGAACTCCGCTGGAAAGGACCAACCC
TGAGGATCTGGCTGGCCGCCCTCGATGAGCAGTCCGTGCGTAAGGCGCTGGCATCGCTCAAGGATAACCACGACTACCAG
AATCTCCGAAACTCAGCCGAAGCCCGTGCCCGCGCGGACTGGCTCATGGGCATGAATCTCACCCGTGCTTTCACCCTGCG
CAACAGCGGCGCCGGAGTCGTCTCCGTGGGTCGGGTGCAGACGCCGACCTTGGCTCTGGTCGTGGCCCGTGATGAGAAGA
TCGAGCACTTCAAGCCGAAGGACTACTACGTTCCGCGCATCAACGCGGGCTTCTGGGCCACCTGGGAGTTGCGGGAGGAT
TTCGAGGGGGTCGATGCCGAAGGGTATCTCACCGACCGGAAAGCCGCTGACCGGCTGGCATCCCGGGCCAAGGCGGAAGG
CAAGGCCACGGTGAAGGACTTCACCAGCGCGGAAAAGCAGCAGCAGGCACCATTAGGCTTCTCCCTTGCAGAGTTACAAA
AGGTCTGCTCCGCCAAGCTCGGCATGTCGGCACAAAGTGTCCTTGATGCGGCCCAGGCGCTGTACGAGGAGCACAAGGCG
GCGACCTATCCCCGGACCGATTGCCGCTATCTTCCGGAAGAACAGCATGGGGATGCCGGACAGATACTGTCCGGCCTGGC
AAAAGCTGGATTTGCGGATCTGGTGAAAGCCGCCGATTCTAACCGGAAGTCGGCCATCTGGAATACGGGCAAAGTGACGG
CGCACCACGCCATCATTCCGACCGGCTCCATGCAGGGCTCTATGAGCCCCGCAGTGGCCAAAGTCTACGATATCATCGTC
CGCTCCTATCTCGCGCAGTTCTATCCGCCCTATGTGTACCGGGCGATCAAGGCTCTACTGACTTGCACCAGCGAGGACTG
GAAGGCGACTGCCAACATCCCGGTATCCGCAGGCTGGAAAGCCGTGTATGGGATGACCGATGACGATAATGATGACACCC
CCGCCCAGCCGATCCCGGCGCTCAAAAAAGGCCAGGTCCTGACCGTCCAGGATGCAGATGTCCAGGCAAAACAGACCAAG
CCGCCGGCCCGATTTACGGATGGGTCGCTCATTGAGGCCATGAGCAACATCCATAAGGTGGTGGAGGATGAAGCCGCCAA
GGCCAAACTCAAGGAAACCTCTGGCCTGGGAACCGAGGCCACTCGGGCCAGCATCATTGAAACGCTGCTGACCCGGGGAT
TCCTGGAGCGCAAAGGCAAGCAGATCCTCTCCACCCAGGCAGGGCGGGCGCTGGTTCACGCGCTGCCCAAAGACCTGACC
GATCCCGTCCTGACGGCACGCTGGGAAGATGCCCTGTCATCCGTGTCTGAGGGCCGCGTGACGCTACAGCAGTTCGAGGA
AGCCCAGCGCAAATTCGTGGTGCGTATGATCGAGGCGGCCAAGGCGACGACCGTAGCTGTCGGCCAGGCACGGCCAACTT
CCGGCGCTGGGCGTGGCAAGTCGTCTACCGGAAAAACGCGGGGCGTCGGACAAAAGACTGGCCCCGCCTGCCCGGACTGC
AAGAAGCTGACCATCACCCTGAAGACGAAGAAGGGCGATGCCTTTTTCAAGTGCGAGGGCTGCCAGTCTTGCTGGTGGCC
GGACAAGCAGGATGCCAAGAAGCTCGGAACGAAGTGGGGGCTAGAAAAGAATGAGTACGTTAGAAGAGAAGACTGGATTT
CTCACACACAGCAGGATTGA

Protein sequence :
MKLYIAEKPSLGKGIAEYLPGSKNKGNGFIQCGVDTVVTWCFGHIFEQEEPDFYTPDDVPTTPKGKKKWRFEELPIFPEQ
WKKRAKDDAKAQIKVIRALLKKASSVVNAGDPDREGQLLVDEVLEELRWKGPTLRIWLAALDEQSVRKALASLKDNHDYQ
NLRNSAEARARADWLMGMNLTRAFTLRNSGAGVVSVGRVQTPTLALVVARDEKIEHFKPKDYYVPRINAGFWATWELRED
FEGVDAEGYLTDRKAADRLASRAKAEGKATVKDFTSAEKQQQAPLGFSLAELQKVCSAKLGMSAQSVLDAAQALYEEHKA
ATYPRTDCRYLPEEQHGDAGQILSGLAKAGFADLVKAADSNRKSAIWNTGKVTAHHAIIPTGSMQGSMSPAVAKVYDIIV
RSYLAQFYPPYVYRAIKALLTCTSEDWKATANIPVSAGWKAVYGMTDDDNDDTPAQPIPALKKGQVLTVQDADVQAKQTK
PPARFTDGSLIEAMSNIHKVVEDEAAKAKLKETSGLGTEATRASIIETLLTRGFLERKGKQILSTQAGRALVHALPKDLT
DPVLTARWEDALSSVSEGRVTLQQFEEAQRKFVVRMIEAAKATTVAVGQARPTSGAGRGKSSTGKTRGVGQKTGPACPDC
KKLTITLKTKKGDAFFKCEGCQSCWWPDKQDAKKLGTKWGLEKNEYVRREDWISHTQQD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
topB NP_807836.1 DNA topoisomerase III Not tested SPI-7 Protein 1e-105 42
topB AAF14809.1 topoisomerase B Not tested SPI-7 Protein 1e-105 42
topB NP_458624.1 topoisomerase B Not tested SPI-7 Protein 1e-105 42