Gene Information

Name : Mchl_4751 (Mchl_4751)
Accession : YP_002423453.1
Strain : Methylobacterium chloromethanicum CM4
Genome accession: NC_011757
Putative virulence/resistance : Resistance
Product : NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1052
EC number : -
Position : 5041675 - 5042685 bp
Length : 1011 bp
Strand : +
Note : PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: mex:Mext_4349 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding

DNA sequence :
ATGGACGTCACGATCTTCAGCACCAAGGCCTATGATCGGCGGTTCCTGGACGAGGCCAACGTGGCGGCGGGAGAGCCGCA
CCGGCTGCGCTATCTCGAAGCCCGGTTGACCCATGAGAGCGCGCCGCTGACGCAGGGAGCGCAGGCCGTGTGCGCCTTCG
TCAACGACGTGCTCGACCGGCCCGTTCTGGAGGTGCTGGCCGCCTCCGGCACGCGGATGGTGGCCCTGCGCAGCGCCGGC
TTCAACAATGTCGATCTTCCCGCCGCCGCGGAACTCGGCATCGCGGTCGGCCGCGTCCCGGCCTACTCGCCGGACGCGGT
CGCTGAGCATACGGTGGCCCTGATCCTCGCGCTCAACCGCAAGACCCACCGGGCCTATGCCCGCGTCCGCGAGGGAAATT
TCGCGCTCGAGGGGTTGCTGGGCTTCGATCTCAAGGGACGCACGGTCGGCATCGTCGGAACCGGCAAGATCGGTCGCGCG
GTCGCACGCATCCTCGCCGGCTTCGGCTGCCGCGTGCTGGCCTACGACCCCATGCCCTCGGCCGAACTCGCCGGCTTCGG
CGCGGAGGCGGTCGGCCTCGACCGGCTTCTGGCCGAGGCGGACATCGTCTCCCTGCACTGCCCGCTGACGCCCGACACGC
ATCACATGATCGACGGTGCCGCGCTGGCGCGGATGAAGCGCGGCGTGATGCTGATCAATACGGGGCGCGGGGCGCTCGTT
GATACCGCGGCGCTGATCGAGGGGTTGAAATCAGGGGTGATCGGCGATCTCGGCCTCGACGTCTACGAGGAGGAAGGCGG
CCTCTTCTTCGAGGATCTGTCGAACCAGATCATCCGGGACGACGTCTTCTCGCGCCTGCTGACCTTCCCGAACGTGATCG
TGACGGGGCATCAGGCCTTCTTCACCGCCGAGGCGCTGGCGGCGATTGCGGCGACCACCATCGAGAACCTGTCCTGCTTC
GAGAAGCAGGGCGTTCCGCGGCATCCCGTATCGGTCGAGCGCCTCGCCTGA

Protein sequence :
MDVTIFSTKAYDRRFLDEANVAAGEPHRLRYLEARLTHESAPLTQGAQAVCAFVNDVLDRPVLEVLAASGTRMVALRSAG
FNNVDLPAAAELGIAVGRVPAYSPDAVAEHTVALILALNRKTHRAYARVREGNFALEGLLGFDLKGRTVGIVGTGKIGRA
VARILAGFGCRVLAYDPMPSAELAGFGAEAVGLDRLLAEADIVSLHCPLTPDTHHMIDGAALARMKRGVMLINTGRGALV
DTAALIEGLKSGVIGDLGLDVYEEEGGLFFEDLSNQIIRDDVFSRLLTFPNVIVTGHQAFFTAEALAAIAATTIENLSCF
EKQGVPRHPVSVERLA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
EF2295 NP_815952.1 D-specific alpha-keto acid dehydrogenase Not tested Not named Protein 2e-39 43
vanHB YP_008394258.1 VanH protein, D-specific alpha-keto acid dehydrogenase Not tested Not named Protein 4e-38 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Mchl_4751 YP_002423453.1 NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase NC_014475.1.orf2.gen Protein 1e-36 44
Mchl_4751 YP_002423453.1 NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase NC_005054.2598279.p0 Protein 1e-36 44
Mchl_4751 YP_002423453.1 NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase U35369.1.gene5.p01 Protein 3e-40 43
Mchl_4751 YP_002423453.1 NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase AF130997.1.orf3.gene Protein 4e-43 42
Mchl_4751 YP_002423453.1 NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase AF310956.2.orf4.gene Protein 8e-39 42
Mchl_4751 YP_002423453.1 NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase AF155139.2.orf4.gene Protein 3e-39 41
Mchl_4751 YP_002423453.1 NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase FJ349556.1.orf3.gene Protein 3e-36 41