Gene Information

Name : Mchl_1891 (Mchl_1891)
Accession : YP_002420682.1
Strain : Methylobacterium chloromethanicum CM4
Genome accession: NC_011757
Putative virulence/resistance : Unknown
Product : thiamine biosynthesis protein ThiC
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0422
EC number : -
Position : 1952708 - 1954600 bp
Length : 1893 bp
Strand : +
Note : required for the synthesis of the hydromethylpyrimidine moiety of thiamine

DNA sequence :
ATGAACGCACCCGTCCGTCCCAAAGATCTTCCCAACAGCAATCCCGCCAGCGTGACCACCGGCCCCGTGCAGGGCTCGCG
CAAGGTCTATGCGGAGGCGCCCGGCCGCCCCGACATCCGCGTGCCCTACCGGGAGATCGCCCTCTCCGACCCGAAGGAGG
AGCCGGTGCGAGTCTACGACCCGTCGGGCCCCTACACCGAGACCGATGCGGCCATCGACCTCGAGAAGGGTCTGGCCCCG
GTCCGCGAGCCGTGGATCGTCGGGCGCGGCTACGCGGCGGTGAAGCCGCGCGAAGTGAAGCCGGAGGACAACGGATTCGC
GGCTGCCGACAAGCTCGTGGCGCCGTGCCCCGCCGAGCGGACGATCCGCCGGGCCGAGCCGGGGCAGTTGGTCACGCAGT
ACGAATTCGCCCGCGCCGGGATCATCACGGAAGAGATGATCTACGTGGCGCATCGCGAGAACGCCTGTCGCGCGCAGATG
CTGGAGCGGGCGGAAGCCGCGCTCGCCGACGGCGACAGCTTCGGCGCGGCGGTGCCGCCCTTCATCACGCCCGAATTCGT
CCGCGACGAGGTGGCCCGCGGCCGCGCGATCATCCCGGCCAACATCAACCACCTCGAACTCGAGCCGATGGCGATCGGCC
GCAATTTTTTGGTGAAAATCAACGCCAATATCGGCAACTCGGCGGTGACGTCTTCCGCGGCTGAGGAAGTCGAAAAACTG
GTCTGGTCGATCCGCTGGGGCGCGGACACGGTCATGGACCTCTCGACGGGCCGCAACATCCACAACATCCGCTCGTGGAT
CGTGCGCAACTCGCCCGTGCCGATCGGCACCGTGCCGATCTATCAGGCGCTGGAAAAGGTCGGCGGCGACCCGCTGAAGC
TCGATTGGGAGGTGTTCAAGGACACGCTCATCGAGCAGGCCGAGCAGGGCATCGACTACTTCACGATCCATGCCGGCGTG
CGGCTGGCTCACGTGCCGCTGACCGCGCGGCGCACCACCGGCATCGTGTCGCGCGGCGGCTCGATCATGGCGCGCTGGTG
CCTCGCCGGGCACCGCGAATCGTTCCTCTATGAGCGGTTCGACGAGATCTGCGACATCATGCGGGCCTACGACGTGTCGT
TCTCGCTCGGCGACGGCCTGCGCCCGGGCTCGATCGCGGATGCCAACGACGCGGCCCAGTTCGCCGAGCTGGAGACCCTG
GGCGAACTCACCAAGATCGCCTGGGACAAGGGCTGCCAGACCATGATCGAGGGCCCCGGCCACGTGCCGATGCACAAGAT
CAAGGTCAACATGGAGAAGCAGCTGCGCGAGTGCGGCGAGGCGCCGTTCTACACCCTCGGCCCGCTGACCACCGACATCG
CTCCGGGCTACGACCACATCACCTCGGGCATCGGCGCGGCGATGATCGGCTGGTTCGGCACGGCGATGCTCTGCTACGTC
ACGCCGAAGGAGCATCTCGGCCTGCCGAACCGCGACGACGTGAAGACCGGCGTCATCACCTACAAGATCGCCGCGCACGC
CGCCGACCTCGCCAAGGGTCACCCCGCCGCGCAGCTCCGCGACGACGCCCTCAGCCGCGCCCGGTTCGACTTCCGTTGGG
AGGACCAGTTCAACCTCTCGCTGGATCCCGACACGGCGCGCGCCTACCACGACGAGACCCTGCCGAAGGACGCGCACAAG
GTCGCCCATTTCTGCTCGATGTGCGGCCCGAAATTCTGCTCGATGAAGATCACGCAGGATCTGCGCGCCGACGTGCTCGC
CATGGAGGAGGCCGGTATCGTCATCGGCCAAGCCCAGCCGATGAGCGACGCCGAGCGCCAGGCCGGCATGGCGGCCAAGT
CGCAGGAGTTCCTGGAAGAGGGCGGCAAGCTCTACGTCGACGCGGCGGAGTAA

Protein sequence :
MNAPVRPKDLPNSNPASVTTGPVQGSRKVYAEAPGRPDIRVPYREIALSDPKEEPVRVYDPSGPYTETDAAIDLEKGLAP
VREPWIVGRGYAAVKPREVKPEDNGFAAADKLVAPCPAERTIRRAEPGQLVTQYEFARAGIITEEMIYVAHRENACRAQM
LERAEAALADGDSFGAAVPPFITPEFVRDEVARGRAIIPANINHLELEPMAIGRNFLVKINANIGNSAVTSSAAEEVEKL
VWSIRWGADTVMDLSTGRNIHNIRSWIVRNSPVPIGTVPIYQALEKVGGDPLKLDWEVFKDTLIEQAEQGIDYFTIHAGV
RLAHVPLTARRTTGIVSRGGSIMARWCLAGHRESFLYERFDEICDIMRAYDVSFSLGDGLRPGSIADANDAAQFAELETL
GELTKIAWDKGCQTMIEGPGHVPMHKIKVNMEKQLRECGEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGTAMLCYV
TPKEHLGLPNRDDVKTGVITYKIAAHAADLAKGHPAAQLRDDALSRARFDFRWEDQFNLSLDPDTARAYHDETLPKDAHK
VAHFCSMCGPKFCSMKITQDLRADVLAMEEAGIVIGQAQPMSDAERQAGMAAKSQEFLEEGGKLYVDAAE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00317 YP_008207782.1 Thiamine biosynthesis protein ThiC Not tested AbaR25 Protein 0.0 64
BJAB0868_00321 YP_008211647.1 Thiamine biosynthesis protein ThiC Not tested AbaR26 Protein 0.0 64
thiC YP_001598318.1 thiamine biosynthesis protein ThiC Not tested MDA Protein 2e-178 61