Gene Information

Name : VS_1884 (VS_1884)
Accession : YP_002417492.1
Strain :
Genome accession: NC_011753
Putative virulence/resistance : Resistance
Product : dihydrofolate reductase
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0262
EC number : -
Position : 2028579 - 2029130 bp
Length : 552 bp
Strand : -
Note : Evidence 1a : Function experimentally demonstrated in the studied strain; PubMedId : 1941991; Product type e : enzyme

DNA sequence : 
TTGGTATGGAGTTCAGTGCGCTTGGCTGGCTCGGTGCTGGTGCACCTTATGCCCGGCGTTAGCCCTATGGAGATAAATTT
GAAATTATCATTGATGGCAGCGGTAGCTGAAAATGGAGTAATTGGCTCTGGCCTGGATATACCTTGGATTGTTAAGGGTG
AGCAGCTGTTGTTTAAGGCAATGACTTTTAATCAATGGTTGCTACTTGGCCGTAAAACTTTTGAATCAATGGGAAAACTG
CCAAACCGTAAATATGCGGTTATTTCTCGTTCTCCATCTACATCGAACGATCCTGATATTTTATATTTCAAAAGTGTTGA
AGACGCCTTGGGTTATTTAGAAACAGTAACCGAGCATGCGTTTGTGTCTGGTGGTGGTCAAATATATAAGTCACTCATTA
CGCAAGTGGACACAATTCATATTTCAAAAATTCATAAACATATCTCTGGTGATATTTTCTTCCCTGAACTACCAAGAGAT
TTGACTCTAGTTTTTGAACAGCGATTTAGTTCAAATATTGATTATACGTACCAAATTTGGCAAAAGGGCTAA

Protein sequence : 
MVWSSVRLAGSVLVHLMPGVSPMEINLKLSLMAAVAENGVIGSGLDIPWIVKGEQLLFKAMTFNQWLLLGRKTFESMGKL
PNRKYAVISRSPSTSNDPDILYFKSVEDALGYLETVTEHAFVSGGGQIYKSLITQVDTIHISKIHKHISGDIFFPELPRD
LTLVFEQRFSSNIDYTYQIWQKG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
dfrA1 AAX48777.1 DfrA1 trimethoprim-insensitive dihydrofolate reductase Not tested SGI2 Protein 3e-46 65
dfrI CAJ77029.1 dihydrofolate reductase type I Not tested AbaR1 Protein 3e-46 65
dfrA1 AGF34987.1 DfrA1 dihydrofolate reductase Not tested SGI1 Protein 3e-46 65
dfrA15 AGK07099.1 DfrA15 dihydrofolate reductase Not tested SGI1 Protein 2e-46 65
dfrA5 AFG30110.1 dihydrofolate reductase Not tested PAGI-2 Protein 7e-40 60
dfrA1 ADZ05803.1 trimethoprim-insensitive dihydrofolate reductase Not tested AbaR3 Protein 1e-41 60
unnamed AEL12695.1 DfrA5 Not tested AbaR21 Protein 1e-41 60
dfrA5 AET25387.1 dihydrofolate reductase Not tested PAGI-2(C) Protein 7e-40 60