Gene Information

Name : invA (ECUMN_3202)
Accession : YP_002413886.1
Strain : Escherichia coli UMN026
Genome accession: NC_011751
Putative virulence/resistance : Virulence
Product : invasion protein
Function : -
COG functional category : U : Intracellular trafficking, secretion and vesicular transport
COG ID : COG4789
EC number : -
Position : 3313459 - 3315519 bp
Length : 2061 bp
Strand : -
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1624429; Product type t : transporter

DNA sequence :
ATGTTTAACAAAGTTTTGATAGGGTTAAGGAGTCATCCAGAATTAATAATTCTTGGATTAATGGTGATGATTATCGCCAT
GCTCATAATTCCATTGCCCACCTACTTAATCGATTTTTTGATTGGGCTGAACTTAACATTGGCAATACTTGTGTTTTTAG
GATCATTCTATGTTGATAGGATTTTAAGTTTTTCTTCATTCCCATCAATTCTTCTCATCACAACGTTATTTCGTTTGGCG
CTGGCGATCAGTACCAGCCGACTTATACTTCTTGAGGCGGACGCCGGAGAAATTATAACGAGTTTTGGTGAATTCGTTAT
TGGAGATAGCCTGGTAGTTGGTTTTGTTATTTTCTCCATTGTTACTATTGTTCAGTTTATCGTGATTACTAAAGGTTCGG
AACGTGTGGCTGAAGTTGCTGCCCGCTTTTCGCTTGACGGTATGCCAGGTAAACAAATGAGTATTGACGCCGATCTACGC
GCCGGGATCATTGATGCAGATTTAGCAAAAGAACGTCGTAGCGTATTAGAACGAGAGAGTCAGCTGTATGGTTCCTTTGA
TGGTGCGATGAAATTTATCAAAGGTGATGCTATTGCAAACATTATTATTATCTTTGTTAATATTATCGGTGGGCTATCAG
TAGGAGTAGGCCAAAATGGAATGGATTTCTCGACAGCGTTGACCGTCTACACAATTCTTACCGTCGGTGATGGTCTTGTT
TCACAAATTCCAGCTTTATTAATTGCTATTAGTGCAGGGTTTATCGTAACGCGCGTGAATGGCGATAGTGATAATATGGG
GCAAAATATAATATCCCAGTTATTAAGTAATTCTTTTGTCATTATTGTGACATGTGTCCTCGCGCTAAGTATTGGGTTGC
TTCCAGGTTTTCCCCTTCTTGTGTTTTTATGTTTGGCAGTAATCTTAGGAATTTATTTTTACTTTAAATTCAAAAAGAAA
GGGGTTGAAGAAACGGTTGTTGAGGGAGATATCACCGTTGGGTTGGAACCCTATAATCAGGATGATGATATTTCATTAGG
TATTATTAATAAACTTGATCAGGTTATTACCGAAACGGTACCCTTGGTTTTGATTATGAATAGTGTACAGGCTAAAAAAT
ACACTGAAATCAATCTTGCTGATAGGATTCGTAGTCAGTTTTTTATTGAGTATGGTATCCGTATTCCCGGTATTGTCATT
CGCGAGGGGGAAGGCCTTAATGATGAAGATGTCATATTAATGCTAAATGAAGTCAGAGCCTCGCAATTTAAAATTTATCA
TGATCTTGTCTTGTTGGTTGAATATTCAGATGAAGTGGTTTCGACTTTGATCAAGAAACCTGTCATCGTAAATAATAATG
GTGAACAATATTATTGGGTTACAAAAAGTGATGCCCAAAAATTAACAAAAATTGGCTGTTATACTCGCACGGCCATGGAT
GAAATGTACAATCATTTATCTGTATGTCTGGCTCATAATATTAATGAGTATTTTGGTATACAAGAAACCAAATATATTCT
TGATCAATTAGAGATGAAGTATCCTGATCTATTAAAAGAAATATTAAGATATATAACCGTGCAGCGCATTTCAGAGGTAA
TTCAGCGTCTGATCCAGGAGCGAATTTCAGTGCGCAATATGCGTTTAGTTATGGAGGCTTTAGCATTATGGAGCCCACGA
GAGAAAGATATAATTACACTCGTCGAGCATGTACGAGGTGCATTAGGTCGCTACATTTGCCATAAGTTTTCATATTCTGG
AGAAATTAAAGCAATTGTGATTTCGCCTGAAATAGAGGACAGAATCAGAGATGGTGTCAGGCCTACCGCTGGCGGTACTT
TTCTTAATCTCGATGCATCCGAAGCTGAGATGATTCTGGATAATTTTAAACTGGCTCTTTCTGGAATCAATATTCCTATT
AAAGACATTATTTTACTGGGATCTGTGGATATTCGTCGTTTTATCAAAAAACTTATTGAATCTAGTTATCGAGACCTCGA
AGTACTTTCGTACGGGGAACTAACGGAAAATGTTCCCGTTAATATTCTGAAAACTATTTAG

Protein sequence :
MFNKVLIGLRSHPELIILGLMVMIIAMLIIPLPTYLIDFLIGLNLTLAILVFLGSFYVDRILSFSSFPSILLITTLFRLA
LAISTSRLILLEADAGEIITSFGEFVIGDSLVVGFVIFSIVTIVQFIVITKGSERVAEVAARFSLDGMPGKQMSIDADLR
AGIIDADLAKERRSVLERESQLYGSFDGAMKFIKGDAIANIIIIFVNIIGGLSVGVGQNGMDFSTALTVYTILTVGDGLV
SQIPALLIAISAGFIVTRVNGDSDNMGQNIISQLLSNSFVIIVTCVLALSIGLLPGFPLLVFLCLAVILGIYFYFKFKKK
GVEETVVEGDITVGLEPYNQDDDISLGIINKLDQVITETVPLVLIMNSVQAKKYTEINLADRIRSQFFIEYGIRIPGIVI
REGEGLNDEDVILMLNEVRASQFKIYHDLVLLVEYSDEVVSTLIKKPVIVNNNGEQYYWVTKSDAQKLTKIGCYTRTAMD
EMYNHLSVCLAHNINEYFGIQETKYILDQLEMKYPDLLKEILRYITVQRISEVIQRLIQERISVRNMRLVMEALALWSPR
EKDIITLVEHVRGALGRYICHKFSYSGEIKAIVISPEIEDRIRDGVRPTAGGTFLNLDASEAEMILDNFKLALSGINIPI
KDIILLGSVDIRRFIKKLIESSYRDLEVLSYGELTENVPVNILKTI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ECs3731 NP_311758.1 EivA Not tested LIM Protein 0.0 99
invA YP_217815.1 invasion protein Virulence SPI-1 Protein 0.0 64
invA NP_457290.1 possible secretory protein (associated with virulence) Virulence SPI-1 Protein 0.0 64
invA NP_806499.1 virulence-associated secretory protein Virulence SPI-1 Protein 0.0 64
invA NP_461817.1 needle complex export protein Virulence SPI-1 Protein 0.0 64
invA AAS66860.1 InvA Not tested SSR-2 Protein 1e-155 56
ysaV AAS66840.1 YsaV Not tested SSR-1 Protein 2e-152 55
escV AFO66296.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 1e-90 41
escV AFO66414.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 9e-91 41
escV AAC38382.1 EscV Virulence LEE Protein 3e-89 41
escV NP_290269.1 hypothetical protein Virulence LEE Protein 2e-89 41
escV AAC31514.1 L0035 Virulence LEE Protein 2e-89 41
ECs4569 NP_312596.1 hypothetical protein Virulence LEE Protein 2e-89 41
escV ACU09459.1 EscV protein Virulence LEE Protein 2e-89 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
invA YP_002413886.1 invasion protein VFG0557 Protein 0.0 64
invA YP_002413886.1 invasion protein VFG1006 Protein 2e-173 61
invA YP_002413886.1 invasion protein VFG1780 Protein 3e-143 51
invA YP_002413886.1 invasion protein VFG0064 Protein 2e-103 42
invA YP_002413886.1 invasion protein VFG0813 Protein 1e-89 41
invA YP_002413886.1 invasion protein VFG0729 Protein 2e-89 41