Gene Information

Name : topB (ECUMN_2050)
Accession : YP_002412778.1
Strain : Escherichia coli UMN026
Genome accession: NC_011751
Putative virulence/resistance : Unknown
Product : DNA topoisomerase III
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0550
EC number : 5.99.1.2
Position : 2078209 - 2080221 bp
Length : 2013 bp
Strand : -
Note : decatenates replicating daughter chromosomes

DNA sequence :
TTGGCGAACTGGTGCCAGCGCGCGGCGGTCGTGCCATGGTTGAGATCCGTTAATTCAATGCGGTTGTTTATTGCCGAAAA
ACCGAGTCTGGCGCGCGCCATTGCTGATGTCCTGCCCAAACCGCACCGGAAAGGCGATGGCTTTATCGAGTGCGGTAATG
GTCAGGTAGTGACCTGGTGTATCGGTCACCTGCTTGAGCAGGCGCAGCCAGACGCCTACGACAGCCGCTATGCGCGCTGG
AATCTTGCGGATTTGCCGATTGTCCCGGAAAAGTGGCAATTACAGCCCCGACCCTCCGTGACCAAACAACTTAACGTCAT
CAAACGCTTCCTGCATGAAGCCAGCGAAATCGTTCACGCCGGGGACCCGGATCGTGAAGGGCAATTGCTGGTGGATGAAG
TGCTGGACTATCTGCAACTGGCACCGGAAAAGCGCCAGCAGGTGCAGCGTTGCTTGATAAACGACCTGAACCCGCAGGCG
GTTGAGCGGGCGATCGACCGTCTTCGTTCCAACAGTGAGTTTGTACCGCTGTGCGTTTCTGCGCTGGCGCGAGCCCGAGC
CGACTGGCTGTACGGCATCAATATGACCCGTGCGTATACTATTCTCGGTCGCAATGCCGGTTATCAGGGCGTACTTTCCG
TGGGACGCGTGCAGACGCCCGTGCTCGGGCTGGTAGTGCGCCGCGACGAAGAGATTGAAAACTTCGTGGCGAAAGATTTC
TTTGAAGTCAAAGCGCATATCGTGACACCTGCCGATGAGCGGTTTACCGCTATCTGGCAACCGAGCGAAGCGTGTGAACC
TTATCAGGATGAAGAAGGGCGCTTGTTACATCGTCCGCTGGCGGAGCATGTGGTCAACCGCATCAGCGGCCAACCGGCTA
TTGTCACCAGCTATAACGATAAACGGGAATCAGAATCCGCACCGCTACCGTTTTCTCTTTCGGCGTTGCAGATTGAAGCG
GCAAAACGCTTTGGTCTGAGCGCGCAGAACGTGCTTGATATTTGCCAGAAGTTGTACGAAACGCACAAGCTAATCACTTA
TCCGCGTTCCGATTGCCGCTATTTGCCAGAAGAACATTTTGCCGGACGCCACGCGGTGATGAATGCCATCAGCGTTCATG
CACCAGATCTGTTGCCGCAGCCAGTGGTCGATCCAGATATACGCAACCGCTGCTGGGATGACAAAAAGGTCGATGCACAC
CACGCCATCATCCCGACCGCACGGAGTTCTGCGATCAACCTGACGGAGAACGAAGCGAAGGTCTATAACCTGATTGCCCG
TCAGTACTTGATGCAGTTCTGCCCGGATGCGGTGTTCCGCAAGTGTGTTATCGAACTGGATATTGCCAAAGGCAAATTTG
TCGCTAAAGCGCGTTTTCTTGCTGAAGCAGGCTGGCGCACGCTGTTAGGCAGCAAAGAGCGCGATGAAGAAAACGACGGT
ACGCCATTGCCTGTGGTGGCGAAAGGCGATGAGTTGCTGTGTGAAAAAGGTGAAGTGGTAGAGCGGCAAACCCAGCCGCC
GCGTCATTTTACCGATGCAACACTGCTTTCGGCGATGACCGGAATCGCGCGCTTTGTGCAGGACAAAGATCTGAAAAAGA
TCCTTCGTGCGACCGATGGCCTGGGGACAGAAGCAACCCGTGCCGGGATTATTGAACTGCTGTTCAAGCGAGGCTTCCTG
ACCAAAAAAGGGCGCTATATCCACTCCACCGACGCCGGAAAAGCGCTATTCCATTCGCTGCCAGAAATGGCGACGCGACC
GGACATGACCGCGCACTGGGAATCGGTGCTGACGCAAATCAGTGAAAAGCAGTGTCGCTATCAGGACTTTATGCAGCCGC
TGGTGGGGACATTGTACCAGTTGATTGATCAGGCAAAGCGCACGTCGGTAAGGCAGTTTCGGGGAATAATGGCTCCCGGC
GGTGGAGAAGGGAAGAAAAAGGATTCGCCACGCAAGAGAGCGCCGAAAAAAAGCCCGCCATCAGAAGAGGCGGGCAATGG
AGTGATAATATAA

Protein sequence :
MANWCQRAAVVPWLRSVNSMRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW
NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQA
VERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDF
FEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA
AKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAH
HAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG
TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFL
TKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTSVRQFRGIMAPG
GGEGKKKDSPRKRAPKKSPPSEEAGNGVII

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
topB1 YP_005176228.1 DNA topoisomerase III Not tested ICEPmu1 Protein 2e-109 41