Gene Information

Name : cadB (ECIAI39_4561)
Accession : YP_002410426.1
Strain : Escherichia coli IAI39
Genome accession: NC_011750
Putative virulence/resistance : Virulence
Product : lysine/cadaverine antiporter
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0531
EC number : -
Position : 4766429 - 4767763 bp
Length : 1335 bp
Strand : -
Note : antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein

DNA sequence :
ATGAGTTCTGCCAAGAAGATCGGGCTATTTGCCTGTACCGGTGTTGTTGCCGGTAATATGATGGGGAGCGGTATTGCATT
ATTACCTGCGAACCTAGCAAGTATCGGTGGTATTGCTATCTGGGGTTGGATTATCTCTATTATTGGTGCAATGTCGCTGG
CGTATGTATATGCCCGACTGGCAACAAAAAACCCGCAACAAGGTGGCCCAATTGCTTATGCCGGAGAAATTTCCCCTGCA
TTTGGTTTTCAGACAGGTGTTCTTTATTACCATGCTAACTGGATTGGTAACCTGGCAATTGGTATTACCGCTGTATCTTA
TCTTTCCACCTTCTTCCCAGTATTAAATGATCCTGTTCCGGCGGGTATCGCCTGTATTGCTATCGTCTGGGTATTTACCT
TTGTAAATATGCTCGGCGGTACCTGGGTAAGCCGTTTAACCACTATTGGTCTGGTGCTGGTTCTTATTCCTGTGGTGATG
ACTGCTATTGTTGGCTGGCATTGGTTTGATTCAGCAACTTATGCAGCTAACTGGAATACTGCGGATACCACTGATGGTCA
TGCGATCATTAAAAGTATTCTGCTCTGCCTGTGGGCCTTCGTGGGTATTGAATCCGCAGCAGTAAGTACTGGTATGGTTA
AAAACCCGAAACGTACCGTTCCGCTGGCAACCATGCTGGGTACTGGTTTAGCAGGTATTGTTTACATCGCTGCGACTCAG
GTGCTTTCCGGTATGTATCCGTCTTCTGTAATGGCGGCTTCCGGTGCTCCGTTTGCAATCAGTGCTTCAACTATCCTCGG
TAACTGGGCTGCGCCACTGGTTTCTGCATTCACCGCCTTTGCGTGTCTGACTTCTCTGGGCTCCTGGATGATGTTGGTAG
GCCAGGCAGGTGTACGTGCCGCTAACGACGGTAACTTCCCGAAAGTTTATGGTGAAGTCGACAGCAACGGTATTCCGAAA
AAAGGTCTGCTGCTGGCTGCAGTGAAAATGACTGCCCTGATGATCCTCATCACTCTGATGAACTCTGCCGGTGGTAAAGC
ATCTGACCTGTTCGGTGAACTGACCGGTATCGCAGTACTGCTGACTATGCTGCCGTACTTCTACTCTTGCGTTGACCTGA
TTCGTTTTGAAGGCGTTAACATCCGCAACTTTGTCAGCCTGATCTGTTCTGTACTGGGTTGCGTGTTCTGCTTCATCGCG
CTGATGGGCGCAAGCTCCTTCGAGCTGGCAGGTACCTTCATCGTCAGCCTGATTATCCTGATGTTCTACGCTCGCAAAAT
GCACGAGCGCCAGAGTCACTCAATGGATAACCACACAGCGTCTAACGCACATTAA

Protein sequence :
MSSAKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWIISIIGAMSLAYVYARLATKNPQQGGPIAYAGEISPA
FGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPVLNDPVPAGIACIAIVWVFTFVNMLGGTWVSRLTTIGLVLVLIPVVM
TAIVGWHWFDSATYAANWNTADTTDGHAIIKSILLCLWAFVGIESAAVSTGMVKNPKRTVPLATMLGTGLAGIVYIAATQ
VLSGMYPSSVMAASGAPFAISASTILGNWAAPLVSAFTAFACLTSLGSWMMLVGQAGVRAANDGNFPKVYGEVDSNGIPK
KGLLLAAVKMTALMILITLMNSAGGKASDLFGELTGIAVLLTMLPYFYSCVDLIRFEGVNIRNFVSLICSVLGCVFCFIA
LMGASSFELAGTFIVSLIILMFYARKMHERQSHSMDNHTASNAH

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cadB NP_756989.1 lysine/cadaverine antiporter Not tested PAI II CFT073 Protein 0.0 99
cadB AAL67382.1 cadaverine/lysine antiporter Not tested PAI II CFT073 Protein 0.0 99
unnamed CAD66196.1 putative lysin/cadaverin transporter Virulence PAI III 536 Protein 9e-135 68

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadB YP_002410426.1 lysine/cadaverine antiporter VFG1671 Protein 5e-135 68