Gene Information

Name : nanK (ECIAI39_3711)
Accession : YP_002409614.1
Strain : Escherichia coli IAI39
Genome accession: NC_011750
Putative virulence/resistance : Virulence
Product : N-acetylmannosamine kinase
Function : -
COG functional category : K : Transcription
COG ID : COG1940
EC number : 2.7.1.60
Position : 3872051 - 3872926 bp
Length : 876 bp
Strand : -
Note : catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein

DNA sequence : 
ATGACCACACTGGCGATTGATATCGGCGGTACTAAACTTGCCGCCGCGCTGATTGGCGCTGACGGGCAGATCCGCGATCG
TCGTGAACTTCCTACGCCAGCCAGCCAGACACCAGAAGCCTTGCGTGATGCCTTATCCGCATTAGTCTCTCCGTTGCAAG
TTCATGCGCAGCGGGTTGCTATCGCTTCAACCGGAATTATTCGCGACGGCAGCTTATTGGCGCTGAATCCGCATAATCTC
GGTGGATTACTACACTTTCCGTTAGTTAAAACACTGGAGCAGCTTACCGATTTGCCGACCATTGCCATTAACGACGCGCA
GGCCGCAGCATGGGCGGAGTATCAGGCGCTGGAAGGCGATATAACCGAGATGGTGTTTATCACCGTTTCCACTGGCGTCG
GCGGCGGTGTAGTGAGCGGCGGCAAACTGCTTACCGGCCCTGGAGGTCTGGCGGGGCACATCGGGCATACGCTTGCCGAT
CCGCATGGTCCAGTCTGCGGCTGTGGACGCACAGGTTGCGTGGAGGCGATTGCTTCTGGTCGCGGCATTGCGGCGGCGGC
GCAAGGGGAGTTGGCTGGTGCGAATGCGAAAACTATTTTCACGCACGCTGGGCAGGGCGATGAGCAGGCGCAGCAACTGA
TTCACCGCTCCGCACGTACGCTTGCAAGGCTGATCGCTGATATTAAAGCCACAACTGATTGCCAGTGCGTGGTGGTCGGT
GGCAGCGTTGGTCTGGCAGAGGGGTATCTGGCGCTGGTGGAAACGTATCTGGCGCAGGAGCCAGCGGCATTTCATGTTGA
TTTACTGGCGGCGCACTACCGCCATGATGCAGGTTTACTTGGGGCTGCGCTGTTGGCCCTGGGAGAAAAATTATGA

Protein sequence : 
MTTLAIDIGGTKLAAALIGADGQIRDRRELPTPASQTPEALRDALSALVSPLQVHAQRVAIASTGIIRDGSLLALNPHNL
GGLLHFPLVKTLEQLTDLPTIAINDAQAAAWAEYQALEGDITEMVFITVSTGVGGGVVSGGKLLTGPGGLAGHIGHTLAD
PHGPVCGCGRTGCVEAIASGRGIAAAAQGELAGANAKTIFTHAGQGDEQAQQLIHRSARTLARLIADIKATTDCQCVVVG
GSVGLAEGYLALVETYLAQEPAAFHVDLLAAHYRHDAGLLGAALLALGEKL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
nanK YP_002414055.1 N-acetylmannosamine kinase Not tested Not named Protein 2e-38 54
VPI2_0030 ACA01847.1 ROK family protein Not tested VPI-2 Protein 2e-26 41
VC1782 NP_231417.1 N-acetylmannosamine kinase Not tested VPI-2 Protein 3e-26 41
VC0395_A1379 YP_001217322.1 N-acetylmannosamine kinase Not tested VPI-2 Protein 3e-26 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
nanK YP_002409614.1 N-acetylmannosamine kinase VFG1115 Protein 1e-26 41