Gene Information

Name : tetA (p1ECUMN_0054)
Accession : YP_002405954.1
Strain :
Genome accession: NC_011749
Putative virulence/resistance : Resistance
Product : tetracycline efflux transporter
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG2814
EC number : -
Position : 43550 - 44803 bp
Length : 1254 bp
Strand : -
Note : Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6319234, 6298728, 1848846, 2168416, 8995300; Product type t : transporter

DNA sequence : 
TTGATAGAGTTATTTTACCACTCCCTATCAGTGATAGAGAAAAGTGAAATGAATAGTTCGACAAAGATCGCATTGGTAAT
TACGTTACTCGATGCCATGGGGATTGGCCTTATCATGCCAGTCTTGCCAACGTTATTACGTGAATTTATTGCTTCGGAAG
ATATCGCTAACCACTTTGGCGTATTGCTTGCACTTTATGCGTTAATGCAGGTTATCTTTGCTCCTTGGCTTGGAAAAATG
TCTGACCGATTTGGTCGGCGCCCAGTGCTGTTGTTGTCATTAATAGGCGCATCGCTGGATTACTTATTGCTGGCTTTTTC
AAGTGCGCTTTGGATGCTGTATTTAGGCCGTTTGCTTTCAGGGATCACAGGAGCTACTGGGGCTGTCGCGGCATCGGTCA
TTGCCGATACCACCTCAGCTTCTCAACGCGTGAAGTGGTTCGGTTGGTTAGGGGCAAGTTTTGGGCTTGGTTTAATAGCG
GGGCCTATTATTGGTGGTTTTGCAGGAGAGATTTCACCGCATAGTCCCTTTTTTATCGCTGCGTTGCTAAATATTGTCGC
TTTCCTTGTGGTTATGTTTTGGTTCCGTGAAACCAAAAATACACGTGATAATACAGATACCGAAGTAGGGGTTGAGACGC
AATCGAATTCGGTATACATCACTTTATTTAAAACGATGCCCATTTTGTTGATTATTTATTTTTCAGCGCAATTGATAGGC
CAAATTCCCGCAACGGTGTGGGTGCTATTTACCGAAAATCGTTTTGGATGGAATAGCATGATGGTTGGCTTTTCATTAGC
GGGTCTTGGTCTTTTACACTCAGTATTCCAAGCCTTTGTGGCAGGAAGAATAGCCACTAAATGGGGCGAAAAAACGGCAG
TACTGCTCGGATTTATTGCAGATAGTAGTGCATTTGCCTTTTTAGCGTTTATATCTGAAGGTTGGTTAGTTTTCCCTGTT
TTAATTTTATTGGCTGGTGGTGGGATCGCTTTACCTGCATTACAGGGAGTGATGTCTATCCAAACAAAGAGTCATCAGCA
AGGTGCTTTACAGGGATTATTGGTGAGCCTTACCAATGCAACCGGTGTTATTGGCCCATTACTGTTTGCTGTTATTTATA
ATCATTCACTACCAATTTGGGATGGCTGGATTTGGATTATTGGTTTAGCGTTTTACTGTATTATTATCCTGCTATCGATG
ACCTTCATGTTAACCCCTCAAGCTCAGGGGAGTAAACAGGAGACAAGTGCTTAG

Protein sequence : 
MIELFYHSLSVIEKSEMNSSTKIALVITLLDAMGIGLIMPVLPTLLREFIASEDIANHFGVLLALYALMQVIFAPWLGKM
SDRFGRRPVLLLSLIGASLDYLLLAFSSALWMLYLGRLLSGITGATGAVAASVIADTTSASQRVKWFGWLGASFGLGLIA
GPIIGGFAGEISPHSPFFIAALLNIVAFLVVMFWFRETKNTRDNTDTEVGVETQSNSVYITLFKTMPILLIIYFSAQLIG
QIPATVWVLFTENRFGWNSMMVGFSLAGLGLLHSVFQAFVAGRIATKWGEKTAVLLGFIADSSAFAFLAFISEGWLVFPV
LILLAGGGIALPALQGVMSIQTKSHQQGALQGLLVSLTNATGVIGPLLFAVIYNHSLPIWDGWIWIIGLAFYCIIILLSM
TFMLTPQAQGSKQETSA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tetA(B) AAL08445.1 tetracycline resistance protein TetA(B) Not tested SRL Protein 2e-163 100
tetA(B) AEZ06045.1 tetracycline efflux protein Not tested Tn6167 Protein 3e-163 99
tetB AEA34667.1 tetracycline resistance determinant Not tested Not named Protein 2e-163 99
BJAB07104_00277 YP_008207742.1 Permeases of the major facilitator superfamily Not tested AbaR25 Protein 1e-162 99
tetA(B) AFH57202.1 tetracycline resistance protein Not tested AbaR4a Protein 7e-171 99
BJAB0868_00281 YP_008211607.1 Permeases of the major facilitator superfamily Not tested AbaR26 Protein 1e-162 99
tetA(B) AEQ20905.1 tetracycline resistance protein Not tested Tn6166 Protein 1e-162 99
ABZJ_00260 YP_005524216.1 Tetracycline resistance protein, class B (TETA(B) ) (Metal-tetracycline/H(+) antiporter) Not tested AbaR22 Protein 3e-165 99
tetA YP_005797160.1 tetracycline resistance protein, class G (TETA(G)) Not tested AbaR4e Protein 2e-159 99
tet(H) YP_005176248.1 tetracycline efflux protein, class H Not tested ICEPmu1 Protein 3e-77 54
tetA CAJ77034.1 Tetracycline resistance protein Not tested AbaR1 Protein 8e-85 52
tet(G) AAK02051.1 tetracycline resistance protein Not tested SGI1 Protein 2e-81 51
tetA(G) ABZ01843.1 TetA(G) Not tested SGI2 Protein 2e-81 51
tetA(G) AGK06974.1 TetA(G) Not tested SGI1 Protein 2e-81 51
tetA(G) AGK07104.1 TetA(G) Not tested SGI1 Protein 2e-81 51
tetA YP_006098396.1 tetracycline resistance protein Not tested Tn2411 Protein 1e-69 48
tetA(A) ACK44537.1 TetA(A) Not tested SGI1 Protein 8e-70 48
tetA(A) AGK07027.1 TetA(A) Not tested SGI1 Protein 8e-70 48
tetA(A) AGK07085.1 TetA(A) Not tested SGI1 Protein 8e-70 48
tetA CAJ77066.1 Tetracycline resistance protein Not tested AbaR1 Protein 1e-70 46
tetA(A) ACN81011.1 TetA(A) Not tested AbaR5 Protein 1e-70 46

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tetA YP_002405954.1 tetracycline efflux transporter NC_010558.1.6275971. Protein 1e-163 100
tetA YP_002405954.1 tetracycline efflux transporter V00611.gene.p01 Protein 3e-162 99
tetA YP_002405954.1 tetracycline efflux transporter AB084246.gene.p01 Protein 1e-163 99
tetA YP_002405954.1 tetracycline efflux transporter L06798.gene.p01 Protein 3e-91 62
tetA YP_002405954.1 tetracycline efflux transporter AJ250203.gene.p01 Protein 3e-82 59
tetA YP_002405954.1 tetracycline efflux transporter Y19116.gene.p01 Protein 1e-78 55
tetA YP_002405954.1 tetracycline efflux transporter L06940.gene.p01 Protein 1e-79 55
tetA YP_002405954.1 tetracycline efflux transporter Y15510.gene.p01 Protein 5e-78 54
tetA YP_002405954.1 tetracycline efflux transporter CP004022.1.gene2534. Protein 1e-78 54
tetA YP_002405954.1 tetracycline efflux transporter AF038993.gene.p01 Protein 1e-78 54
tetA YP_002405954.1 tetracycline efflux transporter NC_010410.6002612.p0 Protein 5e-85 52
tetA YP_002405954.1 tetracycline efflux transporter AF133140.gene.p01 Protein 5e-85 52
tetA YP_002405954.1 tetracycline efflux transporter AF133139.gene.p01 Protein 2e-83 51
tetA YP_002405954.1 tetracycline efflux transporter NC_011586.7045189.p0 Protein 3e-66 48
tetA YP_002405954.1 tetracycline efflux transporter Y19114.gene.p01 Protein 7e-69 47
tetA YP_002405954.1 tetracycline efflux transporter X75761.gene.p01 Protein 6e-70 47
tetA YP_002405954.1 tetracycline efflux transporter AF070999.gene.p01 Protein 1e-67 46
tetA YP_002405954.1 tetracycline efflux transporter CP001485.1.gene2821. Protein 7e-71 46
tetA YP_002405954.1 tetracycline efflux transporter AF534183.gene.p01 Protein 6e-71 46
tetA YP_002405954.1 tetracycline efflux transporter NC_010410.6002597.p0 Protein 7e-71 46
tetA YP_002405954.1 tetracycline efflux transporter AF121000.gene.p01 Protein 2e-62 45
tetA YP_002405954.1 tetracycline efflux transporter AY264780.2.gene3.p01 Protein 1e-62 44
tetA YP_002405954.1 tetracycline efflux transporter AJ420072.gene.p01 Protein 6e-59 44
tetA YP_002405954.1 tetracycline efflux transporter AY743590.gene.p01 Protein 1e-59 43
tetA YP_002405954.1 tetracycline efflux transporter AF090987.gene.p01 Protein 1e-44 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tetA YP_002405954.1 tetracycline efflux transporter VFG1036 Protein 1e-163 100