Gene Information

Name : nanK (EC55989_3635)
Accession : YP_002404588.1
Strain : Escherichia coli 55989
Genome accession: NC_011748
Putative virulence/resistance : Virulence
Product : N-acetylmannosamine kinase
Function : -
COG functional category : K : Transcription
COG ID : COG1940
EC number : 2.7.1.60
Position : 3719384 - 3720259 bp
Length : 876 bp
Strand : -
Note : catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein

DNA sequence : 
ATGACCACGCTGGCGATTGATATCGGCGGTACTAAACTTGCCGCCGCGCTGATTGGCGCTGACGGGCAGATCCGCGATCG
TCGTGAACTTCCTACGCCAGCCAGCCAGACACCAGAAGCCTTGCGTGATGCCTTATCCGCATTAGTCTCTCCGTTGCAAG
CTCATGCGCAGCGGGTTGCCATCGCTTCAACCGGAATTATTCGCGACGGCAGTTTGCTGGCGCTGAATCCGCATAATCTC
GGTGGATTGCTACACTTTCCGTTAGTCAAAACGCTGGAACAACTTACCAATTTGCCGACCATTGCCATTAACGACGCGCA
GGCTGCAGCATGGGCGGAGTATCAGGCGCTGGAAGGCGATATAACCGATATGGTCTTTATCACCGTTTCCACTGGCGTCG
GCGGCGGTGTAGTGAGCGGTGGCAAACTGCTTACCGGCCCTGGCGGTCTGGCGGGGCACATCGGGCATACGCTTGCCGAT
CCACACGGCCCAGTCTGCGGCTGTGGACGCACAGGTTGCGTGGAAGCAATTGCTTCTGGTCGCGGCATTGCGGCGGCAGC
GCAGGGCGAGCTGGCTGGCGCGGATGCTAGAACTATTTTCACACGCGCCGGGCAGGGCGATGAGCAGGCGCAGCAACTGA
TTCATCTCTCCGCACGTACGCTTGCAAGGCTGATCGCTGATATTAAAGCCACAACTGATTGCCAGTGCGTGGTGGTTGGT
GGCAGCGTTGGTCTGGCAGAAGGGTATCTGGCGTTGGTGGAAATGTATCTGGCGCAGGAGCCAGCGGCATTTCATGTTGA
TTTACTGGCGGCGCACTACCGCCATGATGCAGGTTTACTTGGGGCTGCGCTGTTGGCCCAGGGAGAAAAATTATGA

Protein sequence : 
MTTLAIDIGGTKLAAALIGADGQIRDRRELPTPASQTPEALRDALSALVSPLQAHAQRVAIASTGIIRDGSLLALNPHNL
GGLLHFPLVKTLEQLTNLPTIAINDAQAAAWAEYQALEGDITDMVFITVSTGVGGGVVSGGKLLTGPGGLAGHIGHTLAD
PHGPVCGCGRTGCVEAIASGRGIAAAAQGELAGADARTIFTRAGQGDEQAQQLIHLSARTLARLIADIKATTDCQCVVVG
GSVGLAEGYLALVEMYLAQEPAAFHVDLLAAHYRHDAGLLGAALLAQGEKL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
nanK YP_002414055.1 N-acetylmannosamine kinase Not tested Not named Protein 3e-37 53
VC1782 NP_231417.1 N-acetylmannosamine kinase Not tested VPI-2 Protein 1e-25 41
VC0395_A1379 YP_001217322.1 N-acetylmannosamine kinase Not tested VPI-2 Protein 1e-25 41
VPI2_0030 ACA01847.1 ROK family protein Not tested VPI-2 Protein 7e-26 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
nanK YP_002404588.1 N-acetylmannosamine kinase VFG1115 Protein 4e-26 41