Gene Information

Name : ireA (ECED1_3551)
Accession : YP_002399410.1
Strain : Escherichia coli ED1a
Genome accession: NC_011745
Putative virulence/resistance : Virulence
Product : putative iron-regulated outer membrane virulence protein
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG4771
EC number : -
Position : 3476932 - 3478980 bp
Length : 2049 bp
Strand : -
Note : iron-responsive element (ireA); ireA gene is located on pathogenicity island I (PAI I); outer membrane protein

DNA sequence :
ATGAAGACCAAAAGTATCATTGCTCCGGGCATTGCTGTGATATGTTCTACAGTCATATCATCAGGTTATGCCAGTTCTGA
TAAAAAAGAAGATACGCTTGTTGTTACTGCCTCCGGCTTCACTCAGCAACTCAGAAATGCACCGGCCAGTGTTTCAGTCA
TTACTTCAGAGCAACTGCAAAAAAAACCGGTTTCAGACCTGGTCGATGCGGTAAAAGATGTTGAAGGGATTAGTATCACC
GGTGGGAATGAAAAACCGGATATCAGTATACGTGGGTTAAGTGGCGATTATACATTGATTCTGGTCGATGGACGACGTCA
GAGTGGTCGGGAATCCAGACCAAACGGCAGCGGCGGTTTTGAAGCCGGATTTATCCCTCCTGTGGAAGCAATTGAGCGTA
TTGAAGTTATACGTGGCCCTATGTCTTCCCTGTATGGTTCCGATGCTATCGGAGGAGTTATTAATATCATAACCAAACCT
GTTAATAACCAGACATGGGATGGCGTACTTGGGCTTGGGGGAATTATTCAGGAACATGGGAAATTTGGTAACTCAACCAC
GAATGACTTCTACCTGTCAGGCCCATTGGTTAAGGATAAACTTGGTCTTCAGTTATATGGAGGAATGAACTATCGCAAGG
AAGATAGTATCTCTCAGGGAACACCAGCAAAAAATAATAAGAATATAACGGCAACACTCCAGTTTACTCCGACTGAAAGC
CAGAAGTTTGTTTTTGAATACGGAAAAAATAACCAGGAACATACATTAACACCTGGTGATTCTCTTGATGCCTGGACTAT
GCGGGGAAATCTTAAACAACCAAACAGTAAAAGAGAAACACATAACTCACGTAGTCACTGGGTAGCAGCATGGAATGCCC
AGGGCGAAATACTGCATCCTGAAATTGCTGTTTATCAGGAGAAAGTTATTCGTGAGGTTAAATCTGGTAAAAAAGATAAA
TATAATCATTGGGATCTTAATTACGAGTCAAGAAAACCGGAAATAACCAACACGATCATAGATGCAAAAGTGACGGCATT
TCTGCCGGAAAATGTGCTGACCATCGGAGGTCAATTTCAGCATGCAGAACTCCGTGATGACTCAGCCACAGGTAAAAAAA
CGACAGAAACACAGTCTGTTTCAGTTAAACAGAAAGCTGTTTTTATAGAAAATGAATATGCTGCAACGGATTCTCTCGCC
CTGACTGGAGGGCTGCGCCTCGATAACCATGAAATCTATGGCAGTTACTGGAATCCAAGATTGTATGCTGTTTATAACCT
GACCGATAATCTCACTCTCAAAGGAGGGATCGCAAAAGCATTTCGGGCCCCTTCGATTCGTGAGGTCAGTCCTGGATTTG
GAACACTGACGCAGGGTGGTGCCTCTATTATGTATGGAAACAGGGACCTGAAACCGGAGACCAGTGTAACCGAAGAGATC
GGTATTATTTATAATAATGACAGTGGTTTTTCAGCAAGCGCGACTCTGTTTAATACAGATTTTAAAAATAAGCTGACCAG
TTACGATATAGGCACAAAAGATCCAGTCACTGGGCTAAACACTTTTATTTATGATAATGTGGGTGAGGCAAATATCAGAG
GTGTGGAGCTTGCAACTCAGATTCCTGTGTATGATAAATGGCGTGTATCTGCAAACTATACATTCACTGACTCCCGTCGA
GAAAGCGATGACGAAAGTCTCAATGGCAAGTCGCTGAAAGGGGAACCTCTGGAAAGAACTCCCAGACATGCAGCCAATGC
AAAACTGGAATGGGATTACACTCAGGATATTACATTTTATTCATCTCTGAATTATACAGGAAAACAAATCTGGGCAGCAC
AAAGAAATGGTGCCAAGGTTCCCCGTGTTCGTAATGGATTCACTTCTATGGATATTGGTATGAATTACCAGTTCCTGCCA
GGCACGCTGATTAATTTTGCCGTACTTAACGTCACAGACAGAAAGAGCGAAGATATCGATACCATTGATGGTAACTGGCA
GGTCGATGAAGGACGTCGTTACTGGGCTAATGTGAGAATATCCTTCTGA

Protein sequence :
MKTKSIIAPGIAVICSTVISSGYASSDKKEDTLVVTASGFTQQLRNAPASVSVITSEQLQKKPVSDLVDAVKDVEGISIT
GGNEKPDISIRGLSGDYTLILVDGRRQSGRESRPNGSGGFEAGFIPPVEAIERIEVIRGPMSSLYGSDAIGGVINIITKP
VNNQTWDGVLGLGGIIQEHGKFGNSTTNDFYLSGPLVKDKLGLQLYGGMNYRKEDSISQGTPAKNNKNITATLQFTPTES
QKFVFEYGKNNQEHTLTPGDSLDAWTMRGNLKQPNSKRETHNSRSHWVAAWNAQGEILHPEIAVYQEKVIREVKSGKKDK
YNHWDLNYESRKPEITNTIIDAKVTAFLPENVLTIGGQFQHAELRDDSATGKKTTETQSVSVKQKAVFIENEYAATDSLA
LTGGLRLDNHEIYGSYWNPRLYAVYNLTDNLTLKGGIAKAFRAPSIREVSPGFGTLTQGGASIMYGNRDLKPETSVTEEI
GIIYNNDSGFSASATLFNTDFKNKLTSYDIGTKDPVTGLNTFIYDNVGEANIRGVELATQIPVYDKWRVSANYTFTDSRR
ESDDESLNGKSLKGEPLERTPRHAANAKLEWDYTQDITFYSSLNYTGKQIWAAQRNGAKVPRVRNGFTSMDIGMNYQFLP
GTLINFAVLNVTDRKSEDIDTIDGNWQVDEGRRYWANVRISF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ireA YP_854314.1 iron-regulated outer membrane virulence protein Virulence PAI I APEC-O1 Protein 0.0 98
c5174 NP_757022.1 iron-regulated outer membrane virulence protein Not tested PAI II CFT073 Protein 0.0 98
ireA AAZ04447.1 iron-regulated outer membrane protein Virulence PAI I APEC-O1 Protein 0.0 98
unnamed AAL67402.1 IrgA-like protein Virulence PAI II CFT073 Protein 0.0 98