Gene Information

Name : topB (ECED1_1963)
Accession : YP_002397914.1
Strain : Escherichia coli ED1a
Genome accession: NC_011745
Putative virulence/resistance : Unknown
Product : DNA topoisomerase III
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0550
EC number : 5.99.1.2
Position : 1919762 - 1921774 bp
Length : 2013 bp
Strand : -
Note : decatenates replicating daughter chromosomes

DNA sequence :
TTGGCGAACTGGTGCCAGCGCGCGGCGGTCGTGCCATGGTTGAGATCCGTTAATTCAATGCGGTTGTTTATTGCCGAAAA
ACCGAGTCTGGCGCGCGCCATTGCTGATGTCCTGCCTAAACCGCACCGGAAAGGCGATGGCTTTATCGAGTGCGGTAATG
GTCAGGTGGTGACCTGGTGTATCGGTCACCTGCTTGAGCAGGCGCAGCCAGACGCCTACGACAGCCGCTATGCGCGCTGG
AATCTTGCGGATTTGCCAATTGTCCCGGAAAAGTGGCAATTACAGCCCCGACCCTCCGTGACTAAACAACTTAATGTCAT
CAAACGCTTCCTGCATGAAGCCAGCGAAATCGTTCACGCCGGAGACCCGGATCGCGAAGGGCAACTGCTGGTGGATGAAG
TGCTGGACTACCTGCAACTGGCACCGGAAAAGCGCCAGCAGGTACAGCGTTGTTTGATAAACGACCTGAACCCGCAGGCG
GTTGAGCGGGCGATCGATCGTCTTCGCTCCAATAGCGAGTTTGTACCGCTGTGCGTTTCTGCACTGGCGCGGGCGCGGGC
TGACTGGCTGTACGGCATTAATATGACCCGTGCGTATACCATTCTCGGTCGCAATGCCGGTTATCAGGGCGTGCTTTCCG
TGGGACGCGTGCAGACGCCCGTACTCGGACTGGTGGTGCGCCGCGACGAAGAGATTGAAAACTTCGTGGCGAAAGACTTC
TTTGAAGTCAAAGCACATATCGTGACACCTGCCGATGAGCGGTTTACCGCTATCTGGCAACCGAGCGAAGCGTGTGAACC
GTACCAGGATGAAGAAGGGCGCTTGTTACATCGTCCACTGGCGGAGCATGTGGTTAACCGCATTAGTGGTCAACCAGCTA
TTGTCACCAGCTATAACGATAAACGGGAATCAGAATCCGCGCCGCTGCCTTTTTCGCTTTCGGCGTTGCAGATTGAAGCG
GCTAAACGTTTTGGTCTGAGCGCGCAGAACGTGCTTGATATCTGCCAGAAGCTGTACGAAACGCACAAGCTAATCACTTA
TCCGCGTTCCGATTGCCGCTATTTGCCAGAAGAACATTTTGCCGGACGCCACGCGGTGATGAATGCTATCAGCGTTCATG
CACCGGATCTGTTGCCGCAGCCAGTGGTAGATCCAGATATACGCAACCGCTGTTGGGATGACAAAAAGGTCGATGCGCAC
CACGCCATCATTCCGACCGCACGGAGTTCTGCGATCAACCTGACGGAGAACGAAGCGAAGGTCTATAACCTGATTGCCCG
TCAGTACTTGATGCAGTTCTGCCCGGATGCGGTGTTCCGCAAGTGTGTTATCGAACTGGACATTGCCAAAGGCAAATTTG
TCGCTAAAGCCCGTTTTCTTGCTGAAGCAGGCTGGCGCACGCTGTTAGGCAGCAAAGAGCGCGATGAAGAAAACGACGGC
ACGCCGCTGCCTGTGGTGGCGAAAGGCGATGAATTGTTGTGCGAAAAAGGCGAAGTGGTAGAGCGGCAAACCCAGCCGCC
ACGCCATTTTACCGATGCAACACTGCTTTCGGCGATGACCGGGATCGCACGCTTTGTGCAGGACAAAGATCTGAAAAAGA
TCCTTCGTGCGACCGATGGTTTGGGGACAGAAGCAACGCGTGCCGGGATTATTGAATTGTTGTTCAAGCGGGGTTTCCTG
ACCAAAAAAGGGCGCTATATCCACTCCACCGACGCCGGAAAAGCGCTATTCCATTCGCTGCCAGAAATGGCGACGCGACC
GGACATGACCGCGCACTGGGAATCGGTGCTGACGCAAATCAGCGAAAAGCAGTGTCGCTATCAGGACTTTATGCAGCCGC
TGGTGGGGACATTGTACCAGTTGATTGATCAGGCAAAGCGCACGTCGGTAAGGCAGTTTCGGGGAATAATGGCTCCCGGC
GGTAGAGAAGGGAAGAAAAAGGATTCGCCACGCAAGAGAGCGCCGAAAAAAAGCCCGCCATCAGAAGAGGCGGGCAATGG
AGTGATAACATAA

Protein sequence :
MANWCQRAAVVPWLRSVNSMRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARW
NLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQA
VERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDF
FEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEA
AKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAH
HAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG
TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFL
TKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTSVRQFRGIMAPG
GREGKKKDSPRKRAPKKSPPSEEAGNGVIT

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
topB1 YP_005176228.1 DNA topoisomerase III Not tested ICEPmu1 Protein 2e-109 41