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Name : ECS88_4968 (ECS88_4968) Accession : YP_002394438.1 Strain : Escherichia coli S88 Genome accession: NC_011742 Putative virulence/resistance : Unknown Product : type I restriction-modification system methyltransferase subunit; (hsdM-like) Function : - COG functional category : V : Defense mechanisms COG ID : COG0286 EC number : 2.1.1.72 Position : 4928189 - 4929808 bp Length : 1620 bp Strand : - Note : Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8939428; Product type e : enzyme DNA sequence : ATGGCCAAAGCACCAACTAAAAAAGCCAAAGCAAAGAAAGGCTTTGAAGAAACATTATGGGATACCGCAAACCAACTTCG CGGTAGCGTTGAGTCCTCCGAATACAAGCACGTGGTGTTGAGCCTCGTGTTCCTGAAATTCATCAGCGACAAATTTGAAG CACGCCGCAAAAAAATGATTGCCGATGGGCAAGCTGACTTCCTTGAGATGGAAGTGTTCTACCAGCAGGACAACATTTTC TACCTGCCGGAAGAGGCGCGCTGGTCTTTTATCAAACAAAATGCCAAACAGGACGATATTGCGGTCCGTATTGACACCGC CCTCTCGACCATTGAGAAACGTAACCCCACCCTGAAAGGCGCGCTGCCAGACAACTACTTCAGCCGTCAGAATCTGGAAA CCAAAAAACTGGCGTCACTGATTGATACCATCGACAACATCGAAACGCTGGCACACGAAACTGACGTTGAAACGTTATCG AAAGAAGACCTGGTGGGACGCGTTTACGAATACTTCCTCGGCAAGTTTGCCGCAACCGAAGGCAAAGGCGGTGGTGAGTT CTACACGCCAAAATGTGTGGTTACACTGTTAACTGAAATGCTCGAACCCTTCCAGGGCAAAATTTATGACCCGTGCTGCG GCTCGGCAGGGATGTTCGTGCAGTCGGTGAAGTTTGTCGAGAGCCATCAGGGTAAAAGCCGTGATATCGCGCTGTATGGT CAGGAACTGACAGCCACGACGTATAAACTGGCAAAAATGAACCTCGCCATTCGGGGTCTTTCAGCTAACCTCGGCGAACG CCCGGCAGACACCTTCTTTAGCGACCAGCACCCGGACCTGAAAGCCGACTACATTCTGGCGAACCCGCCGTTCAACCTGA AAGACTGGCGTAATGAAGCCGAATTAACCAAAGATCCACGTTTTGCCGGTTATCGTATGCCGCCAACCGGTAACGCCAAC TACGGCTGGATTTTGCATATGCTCTCCAAGCTGTCGGCTAACGGCACAGCAGGTTTTGTGCTGGCAAACGGTTCGATGAG TTCTAACACCAGCGGTGAAGGCGAGATCCGTGCGCAGATGATCGAAAATGATCTGATCGACTGCATGATCGCCCTACCTG GACAGTTGTTCTACACCACGCAGATCCCGGTGTGTTTATGGTTTATGACCAAATCGAAGGCTGCCGACCCGGCCAAAGGT TATCGTGATCGTCAGGGCGAGACGCTGTTTATTGATGCGCGTAACCTCGGCACCATGATTAGCCGCACAACTAAAGAGTT AACAGCGGAAGATATTGCCACCATCGCCGATACTTACCATGCCTGGCGCAGCACGCCGGAAGAACTGGCTGCACGGATTG CGCGTGGTGACAGCAAGCTGGAAAAATATGAAGACCAGGCAGGCTTCTGCAAAGTCGCGACCCTGCAAGATATTAAAGAT AACGACTATGTGCTGACGCCGGGCCGCTATGTGGGTGCAGCCGAGCAGGAAGAGGACGGCGTGGCATTTGAGACGAAAAT GCGCGAATTGTCGAAGACGTTGTTTGAGCAGATGAAGCAGGCGGAAGAACTGGATCGTGCGATTCGCCAGAATCTGGAGG GGTTAGGTTATGGGAAGTAA Protein sequence : MAKAPTKKAKAKKGFEETLWDTANQLRGSVESSEYKHVVLSLVFLKFISDKFEARRKKMIADGQADFLEMEVFYQQDNIF YLPEEARWSFIKQNAKQDDIAVRIDTALSTIEKRNPTLKGALPDNYFSRQNLETKKLASLIDTIDNIETLAHETDVETLS KEDLVGRVYEYFLGKFAATEGKGGGEFYTPKCVVTLLTEMLEPFQGKIYDPCCGSAGMFVQSVKFVESHQGKSRDIALYG QELTATTYKLAKMNLAIRGLSANLGERPADTFFSDQHPDLKADYILANPPFNLKDWRNEAELTKDPRFAGYRMPPTGNAN YGWILHMLSKLSANGTAGFVLANGSMSSNTSGEGEIRAQMIENDLIDCMIALPGQLFYTTQIPVCLWFMTKSKAADPAKG YRDRQGETLFIDARNLGTMISRTTKELTAEDIATIADTYHAWRSTPEELAARIARGDSKLEKYEDQAGFCKVATLQDIKD NDYVLTPGRYVGAAEQEEDGVAFETKMRELSKTLFEQMKQAEELDRAIRQNLEGLGYGK |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| hsdM | YP_251979.1 | type I restriction-modification system DNA methylase | Not tested | SCCmec | Protein | 2e-139 | 54 |
| hsdM | BAH57701.1 | type I restriction-modification system DNA methylase | Not tested | Type-VII SCCmec | Protein | 4e-139 | 54 |
| hsdM | BAD24842.1 | HsdM protein | Not tested | Type-V SCCmec | Protein | 1e-137 | 53 |
| api49 | CAF28523.1 | putative HsdM-like N-methyl transferase | Not tested | YAPI | Protein | 7e-118 | 45 |
