Gene Information

Name : kpsU (ECS88_3324)
Accession : YP_002392932.1
Strain : Escherichia coli S88
Genome accession: NC_011742
Putative virulence/resistance : Virulence
Product : 3-deoxy-manno-octulosonate cytidylyltransferase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1212
EC number : 2.7.7.38
Position : 3280799 - 3281539 bp
Length : 741 bp
Strand : +
Note : CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS

DNA sequence :
ATGAGCAAAGCAGTTATTGTCATTCCGGCTCGTTATGGCTCATCGCGCCTGCCGGGTAAGCCACTGCTCGATATTGTTGG
TAAACCGATGATCCAGCATGTTTACGAGCGTGCGTTACAGGTGGCGGGCGTTGCGGAAGTTTGGGTGGCAACAGACGATC
AGCGTGTTGAAAAGGCCGTGCAGGCATTTGGCGGGAAAGCCATCATGACGCGCAACGATCATGAATCCGGCACCGATCGG
CTGGTCGAGGTGATGCATAAAGTCGAGGCAGATATCTACATTAACCTGCAGGGCGACGAACCAATGATTCGCCCGCGGGA
TGTAGATACGCTGTTACAAGGAATGCGTGATGACCCCGCGTTGCCAGTGGCAACGCTATGCCACGCGATTTCTGCCGAAG
AAGCGACCGAGCCAAGCACGGTAAAAGTGGTGGTAAATACCCACCAGGATGCGCTTTATTTCAGCCGTTCGCCTATTCCG
TATCCGCGAAATGCTGAAAAAGCGCGCTACCTGAAACACGTCGGTATTTACGCTTATCGTCGCGATGTGCTGCAAAACTA
CAGCCAGTTACCAGAGTCCATGCCAGAGCAGGCAGAATCACTGGAGCAGCTGCGGTTGATGAGCGCAGGGATCAACATCC
GCACATTTGAGGTTGCCGCAACCGGTCCGGGCGTCGACACCCCAGCATGCCTGGAAAAAGTGCGCGCCCTGATGGCACAG
GAACTGGCTGAAAACGCATGA

Protein sequence :
MSKAVIVIPARYGSSRLPGKPLLDIVGKPMIQHVYERALQVAGVAEVWVATDDQRVEKAVQAFGGKAIMTRNDHESGTDR
LVEVMHKVEADIYINLQGDEPMIRPRDVDTLLQGMRDDPALPVATLCHAISAEEATEPSTVKVVVNTHQDALYFSRSPIP
YPRNAEKARYLKHVGIYAYRRDVLQNYSQLPESMPEQAESLEQLRLMSAGINIRTFEVAATGPGVDTPACLEKVRALMAQ
ELAENA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
kpsU AAZ04469.1 CMP-KDO synthetase Virulence PAI I APEC-O1 Protein 5e-115 100
kpsU YP_854332.1 3-deoxy-manno-octulosonate cytidylyltransferase Not tested PAI I APEC-O1 Protein 7e-115 100
kpsU CAE85213.1 KpsU protein Virulence PAI V 536 Protein 1e-112 98