Gene Information

Name : int (ECIAI1_4497)
Accession : YP_002389727.1
Strain : Escherichia coli IAI1
Genome accession: NC_011741
Putative virulence/resistance : Unknown
Product : Prophage integrase
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0582
EC number : -
Position : 4575920 - 4577170 bp
Length : 1251 bp
Strand : +
Note : Evidence 2b : Function of strongly homologous gene; PubMedId : 2403440; Product type h : extrachromosomal origin

DNA sequence :
ATGGCTCTCACCGATATCAAAGTTAGGACTACCAAGCCCTCCGACAAACCCTTCAAACTCACCGATGGGCAGGGTATGCA
CCTGCTAATCAATCCCAATGGTTCAAAATACTGGCGACTCCAATACCGTTTCGATGGCAAACAGAAAGTTTTAGCATTGG
GTGTTTATCCAATGGTCTCTCTTGGTGAAGCTCGCAGGAAGCGAGATGAAGCCAAAAAGTTGGTATCTGATGGTATCGAT
CCTTCCGAGAAGAAAAAAGCAGACAAAATCGAGCAGAGCGAAGCCCTGACATTCGAAGCTGTTGCAAGGGATTGGCATAC
TGCCTGTAAAAGGAAATGGTCTGATTCCCACAGCGAGAGAGTTCTAAAAAGCATGGAAGATGGTCTCTTTACTGCTATTG
GTAGAAGAAAAATATCCGAACTTAATACCAGAGATCTTCTTGCCCCTATCAAGGCTGTTGAAGCTTCCGGGCGATTGGAA
GTTGCTTCCCGATTACAGCAAAGAACAACGGCAGTAATGAGATATGCTGTCCAGAATGGGCTGATAGATTACAACCCTGC
TCAGGAGATGGCAGGAGCTATTGCGGTAGCTAAAAGAGTCCACAGGCCAGCTTTACCATTCGAACGATTCTCAGAACTTT
TAGAACGAATTGATAGTTTCAAGGGTAGAAAACTCACGAAGTTAGCCGTGAAACTCACATTGCTCATTTTCATTCGTTCA
AGTGAACTCAGGTTTGCTCGTTGGTCAGAGATAGATTTCGACAATGCCATGTGGACTATCCCTGGGGAACGTGAGCCATT
GCCAGGGGTCAAACATTCTCATCGAGGCTCAAAAATGAAGACCCCACACCTCGTGCCGTTAAGTCGTCAGGCTTTAGAAC
TCCTCAAAGATATCAGAGAAATCAGCGGTGAATGTGAACTTGTGTTCATTGGTGATCATGATTTTAGAAAGCCTATGAGT
GAAAACACGGTAAACAAGGCTTTAAGGTCTATGGGCTACGACACTACGGTTGAAGTATGTGGACATGGTTTTCGTGCGAT
GGCATGTAGTGCGTTGATCGAATCGGGAAAATGGTCAAGGGATGCTGTTGAACGGCAGATGAGCCACCAAGAGCGAAACT
CCGTTCGTGCTGCCTACATTCATAAAGCAGAACACCTTGATGAAAGAAGGCTTATGTTGCAGTGGTGGGCTGATTACCTT
AATGCCTTGAAAGATAGGTTTATCAGTCCCTTTGATTTTACAACAAAGTAG

Protein sequence :
MALTDIKVRTTKPSDKPFKLTDGQGMHLLINPNGSKYWRLQYRFDGKQKVLALGVYPMVSLGEARRKRDEAKKLVSDGID
PSEKKKADKIEQSEALTFEAVARDWHTACKRKWSDSHSERVLKSMEDGLFTAIGRRKISELNTRDLLAPIKAVEASGRLE
VASRLQQRTTAVMRYAVQNGLIDYNPAQEMAGAIAVAKRVHRPALPFERFSELLERIDSFKGRKLTKLAVKLTLLIFIRS
SELRFARWSEIDFDNAMWTIPGEREPLPGVKHSHRGSKMKTPHLVPLSRQALELLKDIREISGECELVFIGDHDFRKPMS
ENTVNKALRSMGYDTTVEVCGHGFRAMACSALIESGKWSRDAVERQMSHQERNSVRAAYIHKAEHLDERRLMLQWWADYL
NALKDRFISPFDFTTK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
intB CAD42017.1 bacteriophage P4 integrase Not tested PAI II 536 Protein 1e-140 73
ECO111_3718 YP_003236059.1 putative integrase Not tested LEE Protein 2e-137 69
c5216 NP_757064.1 prophage P4 integrase Not tested PAI II CFT073 Protein 3e-138 69
int ADD91747.1 P4 integrase Not tested PAI-I AL862 Protein 1e-139 69
int AAL51003.1 CP4-like integrase Not tested LEE Protein 7e-139 69
int AAT48697.1 CP4-like integrase Not tested PAI I 4787 Protein 7e-139 69
int-phe AAL57571.1 CP4-like integrase Not tested LEE Protein 2e-139 69
int AAL51028.1 CP4-like integrase Not tested LEE Protein 2e-139 69
int-phe AAL60261.1 Int-phe Not tested LEE Protein 2e-139 69
intP4 CAE85151.1 CP4 integrase protein Not tested PAI V 536 Protein 1e-139 69
ECO103_3550 YP_003223418.1 integrase Not tested LEE Protein 2e-139 69
int AAK16198.1 Int Not tested PAI-I AL862 Protein 1e-139 69
ECO26_5300 YP_003232178.1 integrase Not tested LEE Protein 2e-139 69
int CAC81896.1 integrase Not tested LEE II Protein 1e-129 69
ORF_1 AAZ04412.1 phage integrase Not tested PAI I APEC-O1 Protein 4e-138 68
S4822 NP_838459.1 P4-type integrase Not tested SHI-1 Protein 1e-137 68
SF2964 NP_708738.1 P4-type integrase Not tested SHI-1 Protein 1e-137 68
APECO1_3534 YP_854214.1 P4-like integrase Not tested PAI I APEC-O1 Protein 5e-138 68
int AAK00456.1 Int Not tested SHI-1 Protein 4e-128 68
Z4313 NP_289539.1 pathogenicity island integrase Not tested OI-122 Protein 1e-138 68
c3556 NP_755431.1 prophage P4 integrase Not tested PAI I CFT073 Protein 3e-136 68
ECUMN_3322 YP_002414004.1 integrase Not tested Not named Protein 6e-135 67
SESS1296_03598 AFO66301.1 bacteriophage integrase Not tested SESS LEE Protein 5e-127 62
SESS1635_03816 AFO66367.1 bacteriophage integrase Not tested SESS LEE Protein 5e-127 62
STY4821 NP_458899.1 integrase Not tested SPI-10 Protein 5e-114 58
APECO1_1051 YP_853069.1 phage integrase Not tested PAI IV APEC-O1 Protein 8e-74 55
int CAA08754.1 integrase Not tested HPI Protein 2e-106 54
int CAB59974.1 integrase Not tested HPI Protein 3e-107 54
y2393 NP_669700.1 prophage integrase Not tested HPI Protein 9e-106 53
int2 NP_993013.1 integrase Not tested HPI Protein 9e-106 53
int CAA21384.1 - Not tested HPI Protein 9e-106 53
int YP_002346908.1 integrase Not tested HPI Protein 9e-106 53
intB AAD37509.1 P4-like integrase Not tested PAI IV 536 Protein 1e-87 53
unnamed AAD17660.1 unknown Not tested HPI Protein 4e-103 52
int NP_458759.1 bacteriophage integrase Not tested SPI-7 Protein 4e-110 51
int NP_807963.1 bacteriophage integrase Not tested SPI-7 Protein 4e-110 51
unnamed ABR13507.1 phage integrase Not tested PAGI-6 Protein 1e-97 50
int AAD44730.1 Int Not tested SHI-2 Protein 7e-83 45
int CAC39282.1 integrase Not tested LPA Protein 1e-83 45
aec33 AAW51716.1 Int Not tested AGI-3 Protein 1e-83 45
int AAD54663.1 Sai integrase Not tested SHI-2 Protein 3e-81 44
S4835 NP_839238.1 integrase Not tested SHI-2 Protein 4e-81 44
SF3698 NP_709437.1 integrase Not tested SHI-2 Protein 4e-81 44
int AAC31482.1 CP4-like integrase Not tested LEE Protein 1e-81 43
int ACU09430.1 integrase Not tested LEE Protein 1e-81 43
intL NP_290239.1 integrase for prophage 933L and the LEE pathogenicity island Not tested LEE Protein 2e-81 43
ECs4534 NP_312561.1 integrase Not tested LEE Protein 2e-81 43
unnamed AFX83955.1 integrase Not tested SE-PAI Protein 2e-72 41
ESA_03025 YP_001439090.1 hypothetical protein Not tested Not named Protein 4e-72 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
int YP_002389727.1 Prophage integrase VFG1536 Protein 6e-141 73
int YP_002389727.1 Prophage integrase VFG0626 Protein 5e-138 68
int YP_002389727.1 Prophage integrase VFG1693 Protein 1e-136 68
int YP_002389727.1 Prophage integrase VFG0598 Protein 2e-81 44
int YP_002389727.1 Prophage integrase VFG0783 Protein 7e-82 43