Gene Information

Name : nanK (ECIAI1_3364)
Accession : YP_002388699.1
Strain : Escherichia coli IAI1
Genome accession: NC_011741
Putative virulence/resistance : Virulence
Product : N-acetylmannosamine kinase
Function : -
COG functional category : K : Transcription
COG ID : COG1940
EC number : 2.7.1.60
Position : 3450988 - 3451887 bp
Length : 900 bp
Strand : -
Note : catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein

DNA sequence : 
TTGTCAGTGGTACAACACAGCGATGAAAAAGGCGGTGCTATGACCACGCTGGCGATTGATATCGGCGGTACTAAACTTGC
CGCCGCGCTGATTGGCGCTGACGGGCAGATCCGCGATCGTCGTGAACTTCCTACGCCAGCCAGCCAGACACCAGAAGCCT
TGCGTGATGCCTTATCCGCATTAGTCTCTCCGTTGCAAGCTCATGCGCAGCGGGTTGCCATCGCTTCAACCGGGATTATT
CGCGACGGCAGCTTGCTGGCGCTGAATCCGCATAATCTTGGTGGATTGCTACACTTTCCGTTAGTCAAAACGCTGGAACA
ACTTACCGATTTGCCGACCATTGCCATTAACGACGCGCAGGCTGCAGCATGGGCGGAGTATCAGGCGCTGGAAGGCGATG
TAACCGAGATGGTGTTTATCACCGTTTCCACTGGCGTCGGCGGCGGTGTAGTGAGCGGCGGCAAACTGCTTACCGGCCCT
GGCGGTCTGGCGGGGCATATCGGGCATACGCTTGCCGATCCACACGGCCCGGTCTGTGGCTGTGGACGCACAGGTTGCGT
GGAGGCGATTGCTTCTGGTCGCGGCATTGCGGCGGCAGCGCAGGGTGAACTGGCGGGCGCGGATGCGAGAACTATTTTCA
CACGCGCCGGGCAGGGCGACGAGCAGGCGCAGCAGCTGATTCACCGCTCCGCACGTACGCTTGCAAGGCTGATCGCTGAT
ATTAAAGCCACAACTGATTGCCAGTGCGTGGTGGTCGGTGGCAGCGTTGGGCTGGCAGAAGGGTATCTGGCGCTGGTGGA
AACGTATCTGGCGCAGGAGCCAGCGGCATTTCATGTTGATTTACTGGCGGCGCACTACCGCCACGATGCAGGTTTACTTG
GGGCTGCGCTGTTGGCCTAG

Protein sequence : 
MSVVQHSDEKGGAMTTLAIDIGGTKLAAALIGADGQIRDRRELPTPASQTPEALRDALSALVSPLQAHAQRVAIASTGII
RDGSLLALNPHNLGGLLHFPLVKTLEQLTDLPTIAINDAQAAAWAEYQALEGDVTEMVFITVSTGVGGGVVSGGKLLTGP
GGLAGHIGHTLADPHGPVCGCGRTGCVEAIASGRGIAAAAQGELAGADARTIFTRAGQGDEQAQQLIHRSARTLARLIAD
IKATTDCQCVVVGGSVGLAEGYLALVETYLAQEPAAFHVDLLAAHYRHDAGLLGAALLA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
nanK YP_002414055.1 N-acetylmannosamine kinase Not tested Not named Protein 2e-38 53
VC1782 NP_231417.1 N-acetylmannosamine kinase Not tested VPI-2 Protein 6e-27 41
VC0395_A1379 YP_001217322.1 N-acetylmannosamine kinase Not tested VPI-2 Protein 6e-27 41
VPI2_0030 ACA01847.1 ROK family protein Not tested VPI-2 Protein 7e-27 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
nanK YP_002388699.1 N-acetylmannosamine kinase VFG1115 Protein 3e-27 41