Gene Information

Name : spaP (ECIAI1_2981)
Accession : YP_002388324.1
Strain : Escherichia coli IAI1
Genome accession: NC_011741
Putative virulence/resistance : Virulence
Product : surface presentation of antigens protein SpaP
Function : -
COG functional category : U : Intracellular trafficking, secretion and vesicular transport
COG ID : COG4790
EC number : -
Position : 3053662 - 3054327 bp
Length : 666 bp
Strand : -
Note : part of a type III secretory system probably involved in invasion into eukaryotic cells

DNA sequence :
ATGTCAAATAGCATTTCGCTGATAGCGATATTATCATTATTTACACTATTGCCGTTTATAATAGCATCCGGGACATGTTT
TATTAAATTCTCGATTGTTTTTGTTATTGTCCGAAACGCGCTGGGACTTCAGCAAGTGCCATCAAATATGACACTTAATG
GGGTTGCTTTGCTATTGTCAATGTTCGTAATGATGCCGGTTGGGAAGGAAATATATAATAACAGTCAGAATGAGAATCTT
TCATTCAATAATGTAGCATCGGTTGTTAATTTTGTTGAGACAGGCATGAGTGGTTATAAATCATATTTGATAAAATATTC
TGAACCTGAGTTGGTTAGCTTTTTTGAAAAGATTCAGAAGGTGAATAGTTCTGAAGACAATGAAGAGATAATCGATGATG
ATAATATTTCAATTTTCTCGTTACTGCCCGCATATGCATTGAGTGAGATAAAAAGTGCATTTATTATAGGTTTTTATATC
TATTTACCCTTTGTCGTAGTGGATCTGGTTATATCCAGCGTTCTGTTAACGTTAGGTATGATGATGATGAGTCCGGTAAC
CATATCTACACCGATAAAATTAATTTTGTTTGTCGCGATGGACGGTTGGACAATGTTATCAAAAGGGCTCATTTTACAAT
ATTTTGACCTATCCATTAATCCCTGA

Protein sequence :
MSNSISLIAILSLFTLLPFIIASGTCFIKFSIVFVIVRNALGLQQVPSNMTLNGVALLLSMFVMMPVGKEIYNNSQNENL
SFNNVASVVNFVETGMSGYKSYLIKYSEPELVSFFEKIQKVNSSEDNEEIIDDDNISIFSLLPAYALSEIKSAFIIGFYI
YLPFVVVDLVISSVLLTLGMMMMSPVTISTPIKLILFVAMDGWTMLSKGLILQYFDLSINP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
epaP AAZ31293.1 EpaP Virulence ETT2 Protein 1e-61 99
spaP NP_311752.1 surface presentation of antigens protein SpaP Not tested LIM Protein 1e-63 99
spaP NP_806493.1 surface presentation of antigens protein SpaP Virulence SPI-1 Protein 1e-47 67
spaP YP_217809.1 surface presentation of antigens protein SpaP Virulence SPI-1 Protein 4e-48 67
spaP NP_461811.1 surface presentation of antigens protein SpaP Virulence SPI-1 Protein 4e-48 67
spaP NP_457284.1 secretory protein (associated with virulence) Virulence SPI-1 Protein 1e-47 67
spaP AAS66865.1 SpaP Not tested SSR-2 Protein 4e-47 59
ysaR AAS66846.1 YsaR Not tested SSR-1 Protein 1e-40 58
lscR AAO18040.1 LscR Virulence TTSS locus Protein 2e-24 43
escR AAK26700.1 EscR Virulence LEE Protein 3e-25 43
escR AAL57527.1 EscR Virulence LEE Protein 3e-25 43
escR YP_003223490.1 T3SS structure protein EscR Virulence LEE Protein 4e-25 43
escR CAC81847.1 EscR protein Virulence LEE II Protein 3e-25 43
escR YP_003232138.1 type III secretion system protein Virulence LEE Protein 4e-25 43
escR CAI43889.1 EscR protein Virulence LEE Protein 3e-25 43
escR AAC38369.1 EscR Virulence LEE Protein 1e-24 42
escR AAC31528.1 L0049 Virulence LEE Protein 3e-25 42
escR ACU09473.1 type III secretion system protein EscR Virulence LEE Protein 3e-25 42
escR YP_003236103.1 T3SS structure protein EscR Virulence LEE Protein 4e-25 42
escR NP_290283.1 type III secretion system protein Virulence LEE Protein 4e-25 42
ECs4583 NP_312610.1 type III secretion system protein Virulence LEE Protein 3e-25 42
escR AFO66317.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 4e-22 41
escR AFO66400.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 4e-22 41
unnamed AAL06354.1 EscR Virulence LEE Protein 9e-24 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
spaP YP_002388324.1 surface presentation of antigens protein SpaP VFG0551 Protein 2e-48 67
spaP YP_002388324.1 surface presentation of antigens protein SpaP VFG2455 Protein 1e-46 62
spaP YP_002388324.1 surface presentation of antigens protein SpaP VFG1773 Protein 2e-47 62
spaP YP_002388324.1 surface presentation of antigens protein SpaP VFG1012 Protein 8e-43 59
spaP YP_002388324.1 surface presentation of antigens protein SpaP VFG0394 Protein 8e-26 46
spaP YP_002388324.1 surface presentation of antigens protein SpaP VFG0188 Protein 5e-26 45
spaP YP_002388324.1 surface presentation of antigens protein SpaP VFG0827 Protein 2e-25 42
spaP YP_002388324.1 surface presentation of antigens protein SpaP VFG0715 Protein 7e-25 42