Gene Information

Name : tpx (EFER_1650)
Accession : YP_002382793.1
Strain : Escherichia fergusonii ATCC 35469
Genome accession: NC_011740
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : 1.11.1.-
Position : 1697812 - 1698318 bp
Length : 507 bp
Strand : +
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence : 
ATGTCACAAACCGTTCATTTCCAGGGCAACCCGGTTGCAGTCGCAAACTCCATTCCTCAGGCGGGTAGCAAAGCGCAGCC
TTTTACTCTCGTGGCAAAAGATCTGTCTGACGTCACACTGAGTCAGTTTGCTGGCAAACGCAAAGTGTTAAATATTTTCC
CAAGTATCGATACCGGCGTATGCGCAGCATCGGTACGTAAGTTTAATCAACTGGTAACAGAAATCGACAACACGGTTGTG
CTGTGCGTTTCTGCTGACCTGCCGTTCGCTCAGTCTCGTTTTTGCGGTGCAGAAGGTTTAAATAACGTCATCACCCTCTC
TACTTTCCGCAATGCTGAGTTCCTCAAAAATTATGGTGTAGAAATCACCGACGGCCCGCTGAAAGGTCTGGCAGCACGTG
CAGTTGTCGTTATTGACGAAAATGACAATGTTGTTTTCAGCCAGTTGGTAAATGAAATCACCACCGAACCGGATTACGAC
ACCGCACTCACTGTGCTGAAAGCGTAA

Protein sequence : 
MSQTVHFQGNPVAVANSIPQAGSKAQPFTLVAKDLSDVTLSQFAGKRKVLNIFPSIDTGVCAASVRKFNQLVTEIDNTVV
LCVSADLPFAQSRFCGAEGLNNVITLSTFRNAEFLKNYGVEITDGPLKGLAARAVVVIDENDNVVFSQLVNEITTEPDYD
TALTVLKA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 2e-36 50
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 9e-37 50
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 1e-36 50
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 6e-37 50

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx YP_002382793.1 thiol peroxidase VFG0087 Protein 3e-37 50