Gene Information

Name : megL (BCB4264_A4763)
Accession : YP_002369449.1
Strain : Bacillus cereus B4264
Genome accession: NC_011725
Putative virulence/resistance : Resistance
Product : methionine gamma-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : -
Position : 4616281 - 4617456 bp
Length : 1176 bp
Strand : -
Note : catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine

DNA sequence : 
ATGAAAAAGAAGCATATGGAGACAGCGTTAATTCATCACGGTTATACACCTGAGGAACATAAAGGAAGTTTAACACCACC
TTTATTTCAAACTTCTACATTTACATTCGAGAATGCGCAGCGAGGAGAGGCGAGTTTTGCGGGAGTGGATCCATCTTATA
TTTACTCACGGCTTGGAAATCCAACTGTGAAATTATTTGAAGAACGTATGGCGGTGTTAGAAGGAGGAGAAGAGGCACTT
GCCTTCGGATCTGGTATGGCAGCTATTTCAGCGACTTTAATCGGTTTTTTAAAGGCTGGAGATCATATTATTTGTTCAAA
TGGATTATACGGATGCACGTACGGTTTTTTAGAAGTGTTAGAAGAAAAATTTATGATTACGCATTCGTTTTGTGATATGG
AGACAGAGGTTGATATTGAAAATAAAATTCGCCCAAATACAAAGCTTATTTTCGTTGAAACACCGATTAATCCGACAATG
AAATTAATTGATTTAAAACAAGTGATTCGGGTTGCAAAGCGAAATGGCTTACTTGTTATTGTTGATAATACATTTTGTTC
ACCTTATTTACAAAGACCGCTTGATCTTGGCTGTGACGCTGTTGTGCATAGTGCGACAAAATATATTGGTGGTCACGGTG
ACGTTGTAGCAGGCGTAACAATTTGTAAAACGAAAGCATTAGCTGAAAAGATTCGCCCGATGCGAAAGGATATCGGCGGT
ATTATGGCACCGTTTGATGCGTGGTTATTATTACGCGGGTTAAAGACGTTAGCAGTAAGAATGGATCGTCATTGTGATAA
TGCAGAAAAAATTGTATCGTTCCTAAGAAAACATGATGCGGTAGAAGGTGTTTGGTATCCAGAAGGGGAGTTAGCATCTC
GTCAAATGAAACGCGGGGGCGGTGTTATTTCTTTTTCAGTAAAAGGCGGAAAAGAAGAGACGCAAGCGTTTATTAATGAT
CTTCACTTTATTACAATTGCGGTGAGTTTAGGAGATACAGAAACGTTAATTCAGCATCCAGCAACGATGACGCACGCTGC
GATTCCAGCTGAACTAAGAAAAGAAATGGGCATTTTCGATAATTTAATACGCTTATCAGTCGGTTTAGAATCGTGGGAGG
ATATCGTTTCTGATTTAGAGCAGGCATTAAAGAAAATATCTACTGTAAATCAATGA

Protein sequence : 
MKKKHMETALIHHGYTPEEHKGSLTPPLFQTSTFTFENAQRGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEAL
AFGSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEVDIENKIRPNTKLIFVETPINPTM
KLIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLDLGCDAVVHSATKYIGGHGDVVAGVTICKTKALAEKIRPMRKDIGG
IMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLRKHDAVEGVWYPEGELASRQMKRGGGVISFSVKGGKEETQAFIND
LHFITIAVSLGDTETLIQHPATMTHAAIPAELRKEMGIFDNLIRLSVGLESWEDIVSDLEQALKKISTVNQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-65 43
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 5e-67 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
megL YP_002369449.1 methionine gamma-lyase BAC0207 Protein 4e-90 48