Gene Information

Name : Msil_1581 (Msil_1581)
Accession : YP_002361892.1
Strain : Methylocella silvestris BL2
Genome accession: NC_011666
Putative virulence/resistance : Resistance
Product : dihydropteroate synthase
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0294
EC number : 2.5.1.15
Position : 1710116 - 1710988 bp
Length : 873 bp
Strand : -
Note : KEGG: bid:Bind_0147 dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS

DNA sequence :
TTGAGCGAAACCGGCGCGATCGCCGTCGACCCGGATTCGATGGCGCATAAACGGGACGCATTCCTCGCCCGCATCGGCCT
TGGCGCGCTAATCATGGGCATCGTCAATGTGACGCCGGATTCCTTTTCCGACGGCGGCAAATTCGAAACAGCCGCTGCGG
CGGTGGCGCAGGCGCGCAGGCTCGCGCAGGAGGGCGCGGCGATCATCGACGTCGGAGCGGAATCGACGCGGCCCGGACAC
GAGCCCGTGCCCGCCGAGGTGGAACGCGCACGGCTCGAGCCGCTGCTAGGCGCGATCGTCGCGAGCGTCGCGGAGCCTGT
CTCGATCGACACCTCCAAGGCCTCGGTCGCCCGCTTCGCCACCGGGCAGGGCGTCGCCTTCATCAATGATGTCTGGGGTC
TGCAACGCGATCCGGCCATGGCCGACGTCGTCGCCGAGAGCGGGGCGGGCGTCGTCATCATGCATAATCGCGGCGAGCTC
GACCCCGAATGCGACATTGTCGACGACATGCGGCGCTTCTTCGACAAATCCCTGATGCTTGCTGAAAAAGCGGGCGTGCC
GCGCCAGCGCATCATCCTCGATCCGGGCGTCGGCTTCGGCAAGACGCGGCAGCAAAACCTTCAGGCCATTCATGGCATGC
GCGCGCTTTTGACGTATGAGCTGCCGATCCTGCTCGGCGTCTCGCGCAAATCCTTGCTCCGGTCGCTGGTGCCGGACGCG
CCCGTGTCCGCAGCGCAGGTCGAGCCGCGGCTTGTCGCCACGATCGCCGCTAATCTCGCCGGGGCGGCGGCGGGCGCCGC
CATTTTTCGCGTGCATGACGTCGCCGATCATGTCGCCGCCTTCAAGGTTTTCGATGCTATCGAACGGGCCTGA

Protein sequence :
MSETGAIAVDPDSMAHKRDAFLARIGLGALIMGIVNVTPDSFSDGGKFETAAAAVAQARRLAQEGAAIIDVGAESTRPGH
EPVPAEVERARLEPLLGAIVASVAEPVSIDTSKASVARFATGQGVAFINDVWGLQRDPAMADVVAESGAGVVIMHNRGEL
DPECDIVDDMRRFFDKSLMLAEKAGVPRQRIILDPGVGFGKTRQQNLQAIHGMRALLTYELPILLGVSRKSLLRSLVPDA
PVSAAQVEPRLVATIAANLAGAAAGAAIFRVHDVADHVAAFKVFDAIERA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
sulI2 AFV47959.1 sulphonamide-insensitive dihydropteroate synthase SulI2 Not tested AbaR25 Protein 1e-28 42
sul2 AEZ06044.1 Sul2, sulphonamide-insensitive dihydropteroate synthase Not tested Tn6167 Protein 1e-28 42
sul2 AEA34678.1 dihydropteroate synthase Not tested Not named Protein 1e-28 42
BJAB0868_00253 YP_008211579.1 Dihydropteroate synthase-related enzyme Not tested AbaR26 Protein 2e-28 42
ABK1_0255 YP_005512827.1 Dihydropteroate synthase type-2 Not tested AbaR4d Protein 2e-28 42
BJAB07104_00246 YP_008207711.1 Dihydropteroate synthase-related enzyme Not tested AbaR25 Protein 2e-28 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Msil_1581 YP_002361892.1 dihydropteroate synthase CP002695.1.gene1085. Protein 3e-26 45
Msil_1581 YP_002361892.1 dihydropteroate synthase AM180355.1.gene1650. Protein 6e-36 45
Msil_1581 YP_002361892.1 dihydropteroate synthase NC_008702.1.4608834. Protein 1e-25 43
Msil_1581 YP_002361892.1 dihydropteroate synthase CP000675.2.gene3019. Protein 3e-33 42
Msil_1581 YP_002361892.1 dihydropteroate synthase NC_002516.2.881715.p Protein 4e-31 41
Msil_1581 YP_002361892.1 dihydropteroate synthase NC_007622.3794340.p0 Protein 1e-25 41
Msil_1581 YP_002361892.1 dihydropteroate synthase NC_002952.2860679.p0 Protein 7e-26 41
Msil_1581 YP_002361892.1 dihydropteroate synthase DQ464881.1.gene2.p01 Protein 6e-28 41