Gene Information

Name : LMHCC_2408 (LMHCC_2408)
Accession : YP_002351359.1
Strain : Listeria monocytogenes HCC23
Genome accession: NC_011660
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence ClpC/mecB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 2381878 - 2384340 bp
Length : 2463 bp
Strand : -
Note : -

DNA sequence :
ATGATGTTTGGACGATTTACGCAAAGAGCTCAGAAAGTACTCGCGTTGTCACAAGAAGAGGCGATGCGTTTGAATCATAG
TAATTTAGGAACAGAACATATTTTATTAGGGCTTGTAAGAGAAGGCGAAGGAATTGCGGCGAAAGCTCTCTATGAACTGG
GAATTAGTTCTGAAAAAGTGCAGCAAGAGGTAGAAGGATTAATTGGTCATGGGGAAAAAGCTGTGACGACGATCCAATAT
ACACCTCGTGCGAAAAAAGTAATTGAACTTTCCATGGATGAGGCTCGTAAATTAGGGCATACTTACGTTGGGACAGAACA
TATCTTACTTGGGCTTATTCGTGAAGGCGAAGGAGTTGCGGCGCGTGTTTTAAGTAATCTTGGTATTAGTTTGAATAAAG
CTCGTCAGCAAGTTTTACAGCTCTTAGGCGGCGGTGATGCTACTGGGGCAGGGAGACAAACAAATACGCAAGCTACACCG
ACTTTAGATAGTTTGGCACGTGATTTAACAGTTATTGCTCGGGAAGATAATTTGGATCCGGTTATTGGCCGTTCTAAAGA
AATCCAACGTGTGATTGAAGTACTTAGTCGCCGGACGAAAAATAACCCGGTACTCATCGGGGAACCGGGTGTTGGTAAAA
CAGCGATTGCAGAAGGCTTAGCGCAACAAATTGTTCGTAATGAAGTGCCTGAGACCTTACGTGGAAAACGTGTAATGACA
CTGGATATGGGGACTGTTGTAGCAGGTACAAAATATCGTGGGGAATTCGAAGACCGTTTGAAGAAAGTAATGGATGAAAT
TCGTCAAGCTGGTAATGTTATTCTATTTATTGATGAATTGCATACGTTAATCGGTGCTGGTGGGGCAGAAGGTGCGATTG
ATGCTTCGAATATCTTGAAGCCACCTCTAGCTCGTGGAGAATTGCAATGTATTGGGGCAACAACGCTGGATGAGTACCGT
AAATACATCGAAAAAGATGCGGCGCTTGAGAGACGTTTCCAACCAATCAAAGTAGATGAACCAACTGTAGAAGAATCTAT
TCAAATTTTACATGGATTGCGTGATCGTTATGAAGCGCATCACCGTGTTGCAATTACGGATGAAGCTCTTGAGGCTGCTG
TTCGTCTATCTGATCGTTACATTTCTGACCGTTTCTTACCCGATAAAGCGATTGATGTAATTGATGAATCTGGGTCTAAA
GTACGTTTAAAATCTTTTACAACGCCAAAAAATGTAAAAGAAATGGAAAACAATTTATCTGAATTGAAAAAAGAAAAAGA
TGCGGCTGTTCAAGGACAAGAATTTGAAAAAGCAGCGTCATTACGCGATAAAGAACAAAAACTTAAAAAATCATTAGAAG
AAACAAAAGCGAATTGGCAAGAAAAGCAAGGGCTTGACCATAGTGAAGTAACAGAAGATATTGTTGCTGAAGTTGTTGCT
AGTTGGACTGGGATTCCAGTTGCAAAACTTGCGGAGACAGAGACAAATAAACTTTTAAATATGGAGAAACTTTTACATGA
ACGTGTGATTGGGCAAGATGCTGCGGTGAAAGCTGTTTCGCTAGCTGTACGTCGAGCTCGTGCGGGGCTTAAAGATCCTA
AGCGTCCAATTGGTTCCTTTATTTTCCTTGGACCTACTGGTGTTGGGAAAACAGAACTTGCTCGCGCGCTTGCTGAGTCT
ATGTTTGGCGATGAGGATTCGATGATTCGAATTGACATGTCTGAGTACATGGAGAAATTCTCCACAGCTCGTTTAGTTGG
GGCTCCTCCAGGTTATGTAGGCTATGAAGAAGGTGGGCAACTGACAGAAAAAGTTCGTCAAAAACCTTATTCAGTAGTCC
TTTTAGATGAAATTGAAAAAGCACATCCGGATGTATTTAATATGTTGCTACAAGTGCTTGACGATGGTCGTTTGACTGAT
TCTAAAGGACGAGTGGTTGATTTTAGAAATACGGTTATCATTATGACTTCCAATATTGGGGCTCAAGAAATGAAACAAGA
TAAATCAATGGGCTTTAATGTTATTGATCCGCTTAAAGACCATAAGGCTATGGAGCATCGTGTTTTACAAGATTTAAAAC
AGGCGTTCCGACCAGAGTTTATCAACCGAATTGATGAAACAATTGTATTCCATTCGCTACAAGAAAAAGAATTGAAACAA
ATTGTTACACTGCTCACTGCCCAATTAACGAAACGTCTAGCTGAACGCGATATTCATGTGAAATTGACTGAAGGCGCGAA
AGCTAAAATTGCCAAAGACGGTTATGATCCAGAATACGGAGCCCGTCCTTTGAAACGAGCTATTCAAAAAGAAGTAGAAG
ATATGCTTTCTGAAGAATTGCTTCGTGGCAACATTAAAGTAGGCGATTACGTAGAAATTGGTGTGAAAGATGGCAAGTTG
GAAGTTAGAAAAAAAGATGCACCAAAAAAGAAAACAACCGCCAAAAAGGTAAAAGCTAAATAA

Protein sequence :
MMFGRFTQRAQKVLALSQEEAMRLNHSNLGTEHILLGLVREGEGIAAKALYELGISSEKVQQEVEGLIGHGEKAVTTIQY
TPRAKKVIELSMDEARKLGHTYVGTEHILLGLIREGEGVAARVLSNLGISLNKARQQVLQLLGGGDATGAGRQTNTQATP
TLDSLARDLTVIAREDNLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVRNEVPETLRGKRVMT
LDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNVILFIDELHTLIGAGGAEGAIDASNILKPPLARGELQCIGATTLDEYR
KYIEKDAALERRFQPIKVDEPTVEESIQILHGLRDRYEAHHRVAITDEALEAAVRLSDRYISDRFLPDKAIDVIDESGSK
VRLKSFTTPKNVKEMENNLSELKKEKDAAVQGQEFEKAASLRDKEQKLKKSLEETKANWQEKQGLDHSEVTEDIVAEVVA
SWTGIPVAKLAETETNKLLNMEKLLHERVIGQDAAVKAVSLAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAES
MFGDEDSMIRIDMSEYMEKFSTARLVGAPPGYVGYEEGGQLTEKVRQKPYSVVLLDEIEKAHPDVFNMLLQVLDDGRLTD
SKGRVVDFRNTVIIMTSNIGAQEMKQDKSMGFNVIDPLKDHKAMEHRVLQDLKQAFRPEFINRIDETIVFHSLQEKELKQ
IVTLLTAQLTKRLAERDIHVKLTEGAKAKIAKDGYDPEYGARPLKRAIQKEVEDMLSEELLRGNIKVGDYVEIGVKDGKL
EVRKKDAPKKKTTAKKVKAK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 58
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 1e-96 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
LMHCC_2408 YP_002351359.1 negative regulator of genetic competence ClpC/mecB VFG0079 Protein 0.0 99
LMHCC_2408 YP_002351359.1 negative regulator of genetic competence ClpC/mecB VFG0080 Protein 3e-155 52