Gene Information

Name : megL (BCAH187_A4789)
Accession : YP_002340712.1
Strain : Bacillus cereus AH187
Genome accession: NC_011658
Putative virulence/resistance : Resistance
Product : methionine gamma-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.11
Position : 4441705 - 4442883 bp
Length : 1179 bp
Strand : -
Note : catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine

DNA sequence : 
ATGAAAAAGAAGCATATGGAGACAGCGTTAATTCATCACGGTTATACATCAGAGGCACATAAAGGAAGTTTAACACCGCC
TTTATTTCAAACGTCTACATTTACATTTGAGACTGCGCAGCAAGGAGAGGCGAGTTTTGCGGGAGTGGATCCATCTTATA
TTTACTCAAGACTTGGAAATCCGACTGTGAAATTATTCGAAGAACGTATGGCGGTGTTAGAAGGAGGAGAAGAAGCGCTT
GCTTTCGGATCTGGTATGGCAGCTATTTCCGCAACGTTAATTGGTTTTCTAAAAGCTGGAGATCATATTATTTGTTCAAA
TGGATTATACGGCTGCACATACGGTTTTTTAGAAGTGTTAGAAGAAAAATTTATGATTACGCATTCGTTTTGTGATATGG
AGACAGAGGCTGATATGGAAAATAAAATTCGCCCGAATACAAAGCTTATTTTCGTTGAAACACCGATTAATCCGACAATG
AAATTAATTGATTTAAAACAAGTGATTCGGGTTGCGAAGCGAAATGGGTTACTTGTTATTGTTGATAATACGTTTTGTTC
ACCTTATTTACAAAGACCGCTTGAACTTGGCTGTGACGCGGTTGTTCATAGTGCGACAAAATATATTGGTGGTCACGGTG
ATGTTGTGGCGGGTGTAACAATTTGTAAAACGAAAGCGTTAGCTGAAAAAATCCGCCCGATGCGAAAAGATATCGGCGGT
ATTATGGCACCGTTTGACGCATGGTTATTGTTACGCGGATTAAAGACACTAGCAGTAAGAATGGATCGTCATTGTGATAA
TGCAGAAAAAATTGTATCGTTCCTAAAAAATCATGATGCGGTAGAAGGTGTTTGGTATCCAGAAGGAGAGTTAGCATCTC
GCCAAATGAAACGTGGGGGCGGTGTTATATCTTTTTCAATTAAAGGCGGGAAAGAAGAGACGCAGGCGTTTATTAATGAC
CTTCACTTTATTACAATTGCGGTAAGTTTAGGAGATACAGAAACGTTAATTCAGCACCCAGCAACGATGACGCACGCCGC
GATTCCAGCTGCGTTAAGACAAGAAATGGGCATTTATGATAATTTAATACGTTTATCTGTCGGTTTAGAATCGTGGGAGG
ATATTGTTTCTGATTTAGAGCAAGCGTTAAAGAAAATATCTACTGTTAGTAATCAATAA

Protein sequence : 
MKKKHMETALIHHGYTSEAHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEAL
AFGSGMAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADMENKIRPNTKLIFVETPINPTM
KLIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTKALAEKIRPMRKDIGG
IMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWYPEGELASRQMKRGGGVISFSIKGGKEETQAFIND
LHFITIAVSLGDTETLIQHPATMTHAAIPAALRQEMGIYDNLIRLSVGLESWEDIVSDLEQALKKISTVSNQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-66 43
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 3e-65 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
megL YP_002340712.1 methionine gamma-lyase BAC0207 Protein 2e-89 48