Gene Information

Name : guaA (ABBFA_003388)
Accession : YP_002327262.1
Strain : Acinetobacter baumannii AB307-0294
Genome accession: NC_011595
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 3599533 - 3601101 bp
Length : 1569 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACTACCAATACTCAAATTACTGAAGATCGTATCCTGATCCTGGATTTCGGCTCTCAATATAGTCAGCTCATTGCACG
TCGTGTACGTGAAGCTGGTGTTTACTCTGAAATGTATGCCTTTGATATGTCTGAAGAAGACATTCGTGCTTTTAAGCCAA
ACGGTATCATTTTATCAGGTGGACCTGAGAGTGTGCATGAAGAGGGCAGCCCTCGCGCACCGCAAGTGGTGTTTGAATTA
GGCGTTCCAGTATTGGGTATTTGCTATGGTTTACAAACCATGTCTGAACAGTTAGGCGGTAAAGTTGAGCCGGGTACTGT
ACATGAGTTTGGTTATGCCGAAGTTGATATCGTTAAACGTGACCAACTTATTGGCAACTTACAAGACCGCGAAAACCAAC
TACACGTTTGGATGAGCCACGGCGACAAAGTGAGTCAGATTCCAGAAGGTTTTACGATTACTGCAAGCACACCAAGCTGT
CCAGTTGCTGCTGTAAGTGATGAAACACGCCGTTTTTACGGTGTTCAGTTCCACCCAGAAGTAACACACACGGCAAAAGG
TGAAGAGCTACTTTCTAATTTCGTTCACAAAATTTGTGGATGTGGTGGCCTTTGGACACCTGAACACATCATCGATTTGC
GTGTAGAGCAGTTACGTGAGCAAATTGGTAACGAGAAAGTACTTTTAGGCCTTTCTGGTGGTGTTGACTCATCTGTTGTT
GCTGCACTTTTACACAAAGCGATTGGTGATCAATTAACATGTGTATTTGTTGATAATGGTTTGCTTCGTTTAAACGAAGG
TGACCAAGTGATGCAAATGTTTGCTGAAAACATGGGTATTCGTGTTATTCGTGCAGATGCAGAAGCGCGCTTCTTAAATG
CCCTAGCTGGCGTTACCGATCCTGAAGCGAAGCGTAAAATTATTGGTCGTGAGTTTATTGAAGTATTTGCTGAAGAAGCA
CGTAAACTTGATGGCGTGAAATTCTTGGCGCAAGGTACAATTTACCCAGACGTAATTGAATCTGCTGCAAGCAAACAAGG
TAAAGCACACGTTATTAAATCTCACCACAATGTGGGTGGTTTACCAGACGATTTAGCATTTGAATTGGTTGAGCCTTTAC
GTGACTTGTTTAAAGATGAAGTACGTAAATTAGGTACTACACTTGGCTTGCCACATAGCATGATCTACCGTCATCCATTC
CCGGGCCCAGGTTTAGGCGTTCGTATTTTGGGTGAAGTGAAAAAAGAATATGCAGATATTCTTCGTCTTGCTGATGATAT
CTTTATGCAAGAGCTTCGTGACAGCGGTTGGTATGATAAAACAGCTCAAGCATTTGCTGTCTTCCAACCTGTTAAATCAG
TAGGTGTAGTCGGTGATGGCCGCCGTTATGCATGGGTGATTGCGCTTCGTGCAGTTGAAACAGTTGACTTTATGACAGCT
CGTTTTGCACATTTACCATACGAATTGGTTGATAAAATCTCAACACGCATTATGAACGAAATTAAAGATGTATCACGTGT
GGTATACGACGTGTCATCTAAACCACCAGCAACGATTGAGTGGGAATAA

Protein sequence :
MTTNTQITEDRILILDFGSQYSQLIARRVREAGVYSEMYAFDMSEEDIRAFKPNGIILSGGPESVHEEGSPRAPQVVFEL
GVPVLGICYGLQTMSEQLGGKVEPGTVHEFGYAEVDIVKRDQLIGNLQDRENQLHVWMSHGDKVSQIPEGFTITASTPSC
PVAAVSDETRRFYGVQFHPEVTHTAKGEELLSNFVHKICGCGGLWTPEHIIDLRVEQLREQIGNEKVLLGLSGGVDSSVV
AALLHKAIGDQLTCVFVDNGLLRLNEGDQVMQMFAENMGIRVIRADAEARFLNALAGVTDPEAKRKIIGREFIEVFAEEA
RKLDGVKFLAQGTIYPDVIESAASKQGKAHVIKSHHNVGGLPDDLAFELVEPLRDLFKDEVRKLGTTLGLPHSMIYRHPF
PGPGLGVRILGEVKKEYADILRLADDIFMQELRDSGWYDKTAQAFAVFQPVKSVGVVGDGRRYAWVIALRAVETVDFMTA
RFAHLPYELVDKISTRIMNEIKDVSRVVYDVSSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-142 55
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-142 55
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 4e-142 55
guaA NP_938969.1 GMP synthase Not tested Not named Protein 5e-118 50