|
Name : ureC (Blon_0111) Accession : YP_002321618.1 Strain : Bifidobacterium longum JCM 1222 Genome accession: NC_011593 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : - Position : 131852 - 133573 bp Length : 1722 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGAGAACCATCACCAGAAGCGACTATGCGGGCATGTTCGGGCCGACCACCGGCGATCGGGTGCGCTTGGGGGATACGGG TCTGCTGATCGAGGTCGAGAAGGATTACGCGCGTTATGGCGATGAATTGAAATTCGGCGGCGGAAAATCCTTCCGGGACG GCATGGGGCAGTCATCCGTCCAGAAGGACTCCGAATCGCCGGACACGGTCATCACCAACGCGCTCGTCGTCGATTACACC GGCATCTACAAAGCGGATATCGGCATCAAGGATGGGAAGATCAGCGCGATCGGCAAGGCCGGCAACCCGCAGACCATGGA CGGGGTGACCCCGGGTCTTGCAGTCGGCGCGTGCACGGAGGCAATCGCCGGTGAAGGGCTCATCCTCACCGCCGGCGGCA TCGACACCCATATTCATTTCATCGCGCCGCAGCAAGTCCGCACGGCTCTTGCCGGTGGCGTCACCACCATGGTCGGCGGC GGCACCGGGCCGGCTGACGGCACCAACGCCACCACATGCTCGCCGGGCGCGTTCCACATCGCCCGCATGATCGAAGCCGC CGAAGCCATGCCGGTGAACATCGCGTATCTGGGCAAAGGCAACGGATCATCGCCGGAACCATTGCGCGAGCAGATTCGTG CGGGAGCGGCCGGATTGAAGATCCACGAGGATTGGGGCGCGACCCCGGCCGTCATCGACACGTGCCTCGGTGTCGCCGAC GACATGGACGTGCAGGTGGCCATCCATACGGACACCCTGAATGAGGGAGGATGCGTCGAAGACACCATCGCCGCATTCAA GGGCCGGACCATCCACACCTATCACACCGAAGGGGCGGGCGGCGGCCACGCGCCCGACATCATCCGCGCGGCCAGTTTCC CCAACGTGCTCCCGAGCTCCACGAACCCGACCATGCCGTTCACCCGTAACACCATCGATGAACATCTCGACATGATGATG GTCACGCATCATCTTGACCGCAATGTGCCGGAAGACATCGCCTTCGCCGATTCGCGTATTCGCCCCGAGACCATCGGGGC CGAGGATGTGCTTCATGACCTTGGGCTGATCTCCATGATGAGTTCGGACTCGCAGGCCATGGGACGGGTCGGAGAGGTCA TCACCCGTACCTGGCAGACGGCCGACAAGATGAAAAAGCAACGCGGCCCGCTCCCCGAGGATGCGCACGACGACAACCGC AACGACAATTTCCGTGTGAAGCGGTACGTGTCGAAATACACCATCAATCCGGCCATCACGCACGGCATCTCCGACTACGT CGGTTCCGTCGAAGTCGGGAAAATGGCCGATCTGGTGCTTTGGCAGCCGGCGCTGTTCGGCGCCAAACCGGAGATGATCA TCAAGGGAGGATCGATCCTCCATGCGCGTATGGGCGACGCGAATGCGTCCATACCTACTCCCGAGCCGGTGCTGTACCGC GACATGTTCGGCGCGATGGGCAAAGCCTTGGGCTCCTCATGCGCCACATTCGTCTCGCAGGCCGCCCATGACGACGACAT CGCCGGCCGGCTCGGTCTCGAACGGCAGGTGCTTCCGGTGCGCCACTGCCGTGGCATCGGTAAGAAGGATCTGAAGTTCA ATGACACCATCGCGGATATTCAGGTCAACCCCGAGACGTTCCAAGTGAGCGTCGACGGCGAGCCGATTCACAGCGAACCG GTGGCGGAACTGCCGTTGGCGCAGCGGTACTTCCTGTTCTAG Protein sequence : MRTITRSDYAGMFGPTTGDRVRLGDTGLLIEVEKDYARYGDELKFGGGKSFRDGMGQSSVQKDSESPDTVITNALVVDYT GIYKADIGIKDGKISAIGKAGNPQTMDGVTPGLAVGACTEAIAGEGLILTAGGIDTHIHFIAPQQVRTALAGGVTTMVGG GTGPADGTNATTCSPGAFHIARMIEAAEAMPVNIAYLGKGNGSSPEPLREQIRAGAAGLKIHEDWGATPAVIDTCLGVAD DMDVQVAIHTDTLNEGGCVEDTIAAFKGRTIHTYHTEGAGGGHAPDIIRAASFPNVLPSSTNPTMPFTRNTIDEHLDMMM VTHHLDRNVPEDIAFADSRIRPETIGAEDVLHDLGLISMMSSDSQAMGRVGEVITRTWQTADKMKKQRGPLPEDAHDDNR NDNFRVKRYVSKYTINPAITHGISDYVGSVEVGKMADLVLWQPALFGAKPEMIIKGGSILHARMGDANASIPTPEPVLYR DMFGAMGKALGSSCATFVSQAAHDDDIAGRLGLERQVLPVRHCRGIGKKDLKFNDTIADIQVNPETFQVSVDGEPIHSEP VAELPLAQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 1e-167 | 64 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 1e-167 | 64 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-170 | 62 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-170 | 62 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 2e-170 | 62 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-170 | 62 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_002321618.1 | urease subunit alpha | VFG0270 | Protein | 2e-174 | 67 |
