Gene Information

Name : entE (AB57_2810)
Accession : YP_002320149.1
Strain : Acinetobacter baumannii AB0057
Genome accession: NC_011586
Putative virulence/resistance : Virulence
Product : enterobactin synthase subunit E
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : 2.7.7.58
Position : 2889101 - 2890729 bp
Length : 1629 bp
Strand : -
Note : bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate

DNA sequence : 
ATGAAAAAACAGTTGATTGAGTTTGTTCGCTGGTCTCCCGAGAGAGCGCAACACTATCGAAATAAAGGTTATTGGATTGA
CCAACCTTTGACGCGCATTTTAACGGTAGGGGTTCAATCGCATCCGCATTCGCCGGCAATTATTTGTGGTGAACGTCAGT
TGAGTTATATCGAGCTGGATCGGCTATCAACAAATTTAGCTTCTCGACTAGCTGAAAAAGGCTTGGGCAAGGGTGATACT
GCTTTAGTACAACTTCCCAATGTTGCGGAGTTTTATATTGTCTTTTTTGCCTTGCTTAAAGCAGGCGTGGTTATGCTCAA
TGCGCTATATAGCCATCGCCAATATGAACTAAATGCCTTCATTAAACAGATTCAACCTAAGCTTTTAATTGGTTCGCGTC
AGCATGAAGTCTTTAGCAATAATCAATTTATTGACTCACTTCATGAAGTAAATTTAAGTCCTGAAATTATTTTGATGTTC
AATCATCAAGCTACCGATTTTGGATTATTAGACTGGATTGAAACACCAGTAGAGACCTTTGTCGATTTTTCATCTACACC
TGCTGATGAAGTTGCTTTCTTTCAGTTGTCAGGTGGAAGTACGGGAACACCAAAACTTATTCCACGCACGCATAATGACT
ATGACTATAGTGTGCGAGCCAGTGCCGAGATTTGCGGTTTAAACTCAAATACCCGGTTATTATGTGCTCTGCCAGCTCCG
CATAACTTTATGTTGAGCTCACCTGGTGCATTAGGTGTTTTACATGCAGGTGGATGTGTTGTTATGGCACCAAATCCTGA
ACCGCTCAATTGTTTTTCTATTATTCAAAGACATCAAGTCAATATGGCATCTTTAGTGCCGAGTGCTGTCATTATGTGGC
TAGAAAAAGCCGCGCAATATAAAGATCAAATTCAGTCTTTAAAGTTGCTTCAAGTAGGTGGAGCAAGTTTCCCTGAATCT
TTAGCCCGTCAAGTTCCTGAAGTCCTCAATTGTAAATTACAACAAGTATTTGGAATGGCCGAAGGCTTGGTCAATTACAC
CAGACTCGATGACTCCGACGAGCAAATCTTTACGACACAAGGGCGTCCTATCAGTTCTGATGATGAAATCAAAATTGTAG
ATGAGCAGTATAGAGAAGTTCCGGAAGGTGAAGTAGGAATGCTTGCGACTCGGGGGCCTTATACCTTTTGTGGTTATTAC
CAAAGCCCTGAACATAATTCACAGGTCTTTGATGAGGACAACTATTACTATTCGGGCGATCTCGTGCAGCGTACCCATGA
TGGCAATTTACGTGTAGTAGGAAGAATTAAAGACCAAATTAACCGTGGTGGTGAAAAAATTGCTTCGGAAGAAATAGAAA
AACTTATTCTTTTACATCCGGAAGTTATGCACGCAGCTTTGGTTGCAATTGTTGATGAACAATTCGGTGAAAAAAGTTGT
GCCTTTATTGTTTCTCGGAATCCTGAACTTAAAGCTGTTGTGCTCAGACGCCATCTCATGGAGTTGGGTATTGCACAATA
TAAGCTTCCAGACCAGATCAAATTAATCGAATGTTTGCCACTGACCGCAGTCGGTAAGGTGGACAAAAAACAACTTCGCA
GCATTTTAAATACATCTACAACATCTTAA

Protein sequence : 
MKKQLIEFVRWSPERAQHYRNKGYWIDQPLTRILTVGVQSHPHSPAIICGERQLSYIELDRLSTNLASRLAEKGLGKGDT
ALVQLPNVAEFYIVFFALLKAGVVMLNALYSHRQYELNAFIKQIQPKLLIGSRQHEVFSNNQFIDSLHEVNLSPEIILMF
NHQATDFGLLDWIETPVETFVDFSSTPADEVAFFQLSGGSTGTPKLIPRTHNDYDYSVRASAEICGLNSNTRLLCALPAP
HNFMLSSPGALGVLHAGGCVVMAPNPEPLNCFSIIQRHQVNMASLVPSAVIMWLEKAAQYKDQIQSLKLLQVGGASFPES
LARQVPEVLNCKLQQVFGMAEGLVNYTRLDDSDEQIFTTQGRPISSDDEIKIVDEQYREVPEGEVGMLATRGPYTFCGYY
QSPEHNSQVFDEDNYYYSGDLVQRTHDGNLRVVGRIKDQINRGGEKIASEEIEKLILLHPEVMHAALVAIVDEQFGEKSC
AFIVSRNPELKAVVLRRHLMELGIAQYKLPDQIKLIECLPLTAVGKVDKKQLRSILNTSTTS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-81 41
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 8e-82 41
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 6e-82 41
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 8e-82 41
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 8e-82 41
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 8e-82 41
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 8e-82 41
ybtE CAA21394.1 - Virulence HPI Protein 8e-82 41
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 6e-82 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
entE YP_002320149.1 enterobactin synthase subunit E VFG0932 Protein 5e-140 56
entE YP_002320149.1 enterobactin synthase subunit E VFG0168 Protein 2e-104 43